Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 12/20 | 0.88 |
| ▸ | HDAC4 | P56524 | 12/20 | 0.88 |
| ▸ | HDAC1 | Q13547 | 12/20 | 0.88 |
| ▸ | HDAC7 | Q8WUI4 | 12/20 | 0.88 |
| ▸ | HDAC2 | Q92769 | 12/20 | 0.88 |
| ▸ | HDAC10 | Q969S8 | 12/20 | 0.88 |
| ▸ | HDAC11 | Q96DB2 | 12/20 | 0.88 |
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.88 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.88 |
| ▸ | HDAC9 | Q9UKV0 | 12/20 | 0.88 |
| ▸ | HDAC5 | Q9UQL6 | 12/20 | 0.88 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.88 |
| ▸ | EGFR | P00533 | 10/20 | 0.88 |
| ▸ | KDR | P35968 | 6/20 | 0.88 |
| ▸ | GAK | O14976 | 3/20 | 0.88 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.88 |
| ▸ | BUB1 | O43683 | 2/20 | 0.88 |
| ▸ | STK10 | O94804 | 2/20 | 0.88 |
| ▸ | ABL1 | P00519 | 2/20 | 0.88 |
| ▸ | LCK | P06239 | 2/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4740600 | 0.93 | HDAC3 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Cudc-101 SCHEMBL29379912 | 0.93 | HDAC3 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL641667 | 0.93 | HDAC3 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL8212688 | 0.93 | HDAC3 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Cudc-101 SCHEMBL93769 | 0.93 | HDAC3 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Cudc-101 SCHEMBL29350202 | 0.93 | HDAC3 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL642988 | 0.93 | HDAC3 (0.86) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL643712 | 0.92 | HDAC3 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL31424948 | 0.92 | HDAC3 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL8213005 | 0.92 | HDAC3 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150051288-A1 | Methods and Compositions for Treatment of Autism | UNIV JOHNS HOPKINS (US) | 2015-02-19 | — | — | US | disclosed |
| US-8937050-B2 | Methods and compositions for treatment of autism | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-01-20 | — | — | US | disclosed |
| US-20130123203-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF AUTISM | KENNEDY KRIEGER INSTITUTE, INC. | 2013-05-16 | — | — | US | disclosed |
| WO-2009042646-A1 | ANTI-PROLIFERATIVE AGENTS | CURIS, INC. (US) | 2009-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150051288-A1 | Methods and Compositions for Treatment of Autism | CHAT, AHCY, SYNGR2 | HDAC3 730/4885HDAC4 659/4885HDAC1 1025/4885 |
| US-20130123203-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF AUTISM | CHAT, AHCY, SYNGR2 | HDAC3 730/4885HDAC4 659/4885HDAC1 1025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.