Sugi Predict

Sugi Predict / Targets / ALYREF

ALYREF

THO complex subunit 4 · Q86V81 · ALYREF on Sugi Atlas →

0 patent compounds predicted against ALYREF, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to ALYREF by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47) PHASE1/PHASE2NOT_YET_RECRUITING
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus nanCOMPLETED
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM) nanCOMPLETED
Signs and Symptoms of Genetic Abnormalities Linked to Inherited Heart Disease nanCOMPLETED
Genetic Analysis of Hereditary Disorders of Hearing and Balance nanCOMPLETED
Mapping Novel Disease Genes for Dilated Cardiomyopathy nanCOMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA nanRECRUITING
Exome Analysis in Hearing Impaired Patients nanUNKNOWN
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia nanNOT_YET_RECRUITING
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease nanRECRUITING
Investigations Into ISCU Myopathy or Iron Sulfur Scaffold U Protein Myopathy nanCOMPLETED
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH) nanCOMPLETED
Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants nanRECRUITING
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Genetic Characterization of Parkinson's Disease nanCOMPLETED
Muscle Tissue Bank for Muscular Dystrophy nanCOMPLETED
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes nanRECRUITING
New Strategies of Genetic Study of Patients With Oculocutaneous Albinism nanCOMPLETED
Elucidating the Molecular and Biochemical Basis of the Human AhR-mutation Disease nanUNKNOWN
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases nanUNKNOWN
Identification of a New Gene Involved in Hereditary Lipodystrophy nanCOMPLETED
PL_GNT01_ISR_Grant 53234273 nanUNKNOWN
Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise nanCOMPLETED
Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis. nanCOMPLETED
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia nanUNKNOWN
Prevalence of a Non-Expressing 11B Mutation in Aka Peoples of the Central African Republic nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a ALYREF binder may also engage these)

ProteinNameSimilarity
O08583 — 1.000 O08583 →
Q28FB9 — 1.000 Q28FB9 →
B5FXN8 — 1.000 B5FXN8 →
Q3T0I4 — 0.999 Q3T0I4 →
Q58EA2 — 0.999 Q58EA2 →
Q6GLW1 — 0.997 Q6GLW1 →
Q9JJW6 — 0.982 Q9JJW6 →
EIF4B Eukaryotic translation initiation factor 4B 0.935 landscape →
Q8BGD9 — 0.931 Q8BGD9 →
HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 0.928 landscape →
Q08DJ0 — 0.927 Q08DJ0 →
Q8BTF8 — 0.924 Q8BTF8 →
Q921F2 — 0.920 Q921F2 →
Q5RA82 — 0.920 Q5RA82 →
Q9Z204 — 0.919 Q9Z204 →
Q91YE7 — 0.919 Q91YE7 →
Q9WU01 — 0.919 Q9WU01 →
Q1RMU5 — 0.918 Q1RMU5 →
P52756 — 0.917 P52756 →
Q5R5W2 — 0.917 Q5R5W2 →
G3V9R8 — 0.917 G3V9R8 →
Q86SE5 — 0.917 Q86SE5 →
B2GV05 — 0.916 B2GV05 →
Q5VWX1 — 0.916 Q5VWX1 →
O75525 — 0.916 O75525 →
O77768 — 0.915 O77768 →
Q6ZVM7 — 0.915 Q6ZVM7 →
Q9R226 — 0.915 Q9R226 →
Q3SZF3 — 0.915 Q3SZF3 →
Q9JLP1 — 0.914 Q9JLP1 →