Sugi Predict

Sugi Predict / Targets / ARHGEF2

ARHGEF2

Rho guanine nucleotide exchange factor 2 · Q92974 · ARHGEF2 on Sugi Atlas →

0 patent compounds predicted against ARHGEF2, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to ARHGEF2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Eicosapentaenoic Acid Cerebral Vasospasm Therapy Study PHASE4COMPLETED
Simvastatin + Cetuximab/Irinotecan in K-ras Mutant Colorectal Cancer (CRC) PHASE2COMPLETED
Safety Evaluation of Gene Therapy in Leber Hereditary Optic Neuropathy (LHON) Patients PHASE1/PHASE2COMPLETED
Interleukin-2 Treatment for Wiskott-Aldrich Syndrome PHASE1COMPLETED
FAK Inhibitor in Patients With Advanced Solid Tumors PHASE1NOT_YET_RECRUITING
Effect of Simvastatin on CF Airway Inflammation PHASE1COMPLETED
ADRB3, ROCK2 and GEF Levels in Overactive Bladder Patients nanCOMPLETED
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma nanRECRUITING
Genetic Characterization of Parkinson's Disease nanCOMPLETED
NCF Gene & TNFSF4 in SLE Patients nanUNKNOWN
NETs: Protection or Harm in Neonatal Inflammation or Infection nanRECRUITING
Identification of an Asthma Susceptibility Gene on 3P nanCOMPLETED
Thrombin Regulated Platelet Activation nanCOMPLETED
Genetic Analysis of Familial Cases of Premature Ovarian Failure nanCOMPLETED
Evaluation of Vasopressin in the Vessels of Ovarian Neoplasms nanCOMPLETED
Role of Polymorphisms in the IL-1 Gene Cluster nanCOMPLETED
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH) nanCOMPLETED
Chromosome 5Q Gene Variants and Asthma-Related Traits nanCOMPLETED
Molecular Markers of Human Sperm Function nanWITHDRAWN
Gene Analysis of Parkinson's Disease nanCOMPLETED
Study of the Genetic and Epigenetic Causes of Recurrent Hydatidiform Moles nanACTIVE_NOT_RECRUITING
Genetic Biomarkers for the Response to Anti-VEGF (Vascular Endothelial Growth Factor).Treatment in Wet Age-related Macular Degeneration (Wet ARMD) nanCOMPLETED
Signs and Symptoms Associated With Molecular Defects in Genetically Inherited Heart Disease nanCOMPLETED
Safety and Efficacy of Combination Acthar Gel and Tacrolimus in the Treatment of Steroid Resistant Nephrotic Syndrome nanSUSPENDED
Genetic Epidemiology of Asthma in Costa Rica nanCOMPLETED
Relationship Between Genes Important in Blood Pressure Regulation and Blood Pressure Therapy in Hypertension nanCOMPLETED
Family Myopia Study nanCOMPLETED
The Influence of Genetic Predisposition on Outcome After Catheter Ablation of Atrial Fibrillation. nanUNKNOWN
Prospective Validation of a DNA Damage Repair-Hippo Pathway Signature in Patients With Advanced Gastric Cancer nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a ARHGEF2 binder may also engage these)

ProteinNameSimilarity
B2DCZ9 — 1.000 B2DCZ9 →
Q865S3 — 1.000 Q865S3 →
Q5FVC2 — 0.999 Q5FVC2 →
Q60875 — 0.999 Q60875 →
Q9BST9 — 0.981 Q9BST9 →
Q6ZT62 — 0.981 Q6ZT62 →
Q6V7V2 — 0.981 Q6V7V2 →
Q9Z206 — 0.981 Q9Z206 →
Q3UFQ8 — 0.980 Q3UFQ8 →
O94810 — 0.980 O94810 →
Q923Q2 — 0.980 Q923Q2 →
MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 0.980 landscape →
Q8C6B2 — 0.979 Q8C6B2 →
Q7Z628 — 0.979 Q7Z628 →
Q0QWG9 — 0.979 Q0QWG9 →
P70268 — 0.979 P70268 →
Q8ND23 — 0.978 Q8ND23 →
Q5XHY1 — 0.978 Q5XHY1 →
PKN1 Serine/threonine-protein kinase N1 0.978 landscape →
A4D2P6 — 0.977 A4D2P6 →
Q13474 — 0.977 Q13474 →
Q9ESJ4 — 0.977 Q9ESJ4 →
Q9Y613 — 0.977 Q9Y613 →
Q5RCJ1 — 0.977 Q5RCJ1 →
Q9QXY1 — 0.976 Q9QXY1 →
O62683 — 0.976 O62683 →
F1LXF1 — 0.976 F1LXF1 →
NIBAN2 Protein Niban 2 0.976 landscape →
Q9BYB0 — 0.975 Q9BYB0 →
Q6F6B3 — 0.975 Q6F6B3 →