Thymine

Thymine

SCHEMBL535796

Cc1c[nH]c(=O)[nH]c1=O.c1cncnc1

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ATAD2 Q6PL18 2/20 0.70
DPYD Q12882 5/20 0.44
ALDH1A1 P00352 3/20 0.39
LMNA P02545 2/20 0.39
GAA P10253 1/20 0.39
MAPT P10636 1/20 0.39
CYP19A1 P11511 1/20 0.39
TSHR P16473 1/20 0.39
THPO P40225 1/20 0.39
MTOR P42345 1/20 0.39
HTT P42858 1/20 0.39
HBB P68871 1/20 0.39
PMP22 Q01453 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Thymine SCHEMBL15174408 1.00 ATAD2 (0.70) ATAD2DPYDALDH1A1LMNAGAA
Thymine SCHEMBL18229756 0.92 ATAD2 (0.59) ATAD2DPYDALDH1A1LMNAGAA
Thymine SCHEMBL29281739 0.89 ATAD2 (0.70) ATAD2DPYDALDH1A1LMNAGAA
Thymine SCHEMBL17144680 0.88 ATAD2 (0.54) ATAD2DPYDALDH1A1LMNAGAA
Thymine SCHEMBL29669526 0.84
Thymine SCHEMBL15323914 0.84 ATAD2 (1.00) ATAD2DPYDALDH1A1LMNAGAA
Thymine SCHEMBL750450 0.84 ATAD2 (1.00) ATAD2DPYDALDH1A1LMNAGAA
Thymine SCHEMBL17201833 0.84 ATAD2 (1.00) ATAD2DPYDALDH1A1LMNAGAA
Thymine SCHEMBL5235 0.84
Pyrimidine SCHEMBL29014623 0.82 ATAD2 (0.46) ATAD2GAAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 175 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240226275-A1 COMPOSITIONS AND METHODS OF MRNA VACCINES AGAINST NOVEL CORONAVIRUS INFECTION RNAimmune, Inc. (US) 2024-07-11 US disclosed
CN-118302181-A Multigang TP53 and PAN-RAS mRNA cancer vaccine 达冕生物有限公司 2024-07-05 CN disclosed
EP-4388017-A1 COMPOSITIONS AND METHODS FOR ANTI-VIRUS CHIMERIC ANTIGEN RECEPTOR Rudd, Christopher E. (CA) 2024-06-26 EP disclosed
EP-4384214-A2 COMPOSITION AND METHODS OF MRNA VACCINES AGAINST NOVEL CORONAVIRUS INFECTION Rnaimmune, Inc. (US) 2024-06-19 EP disclosed
CN-118119930-A Compositions and methods for mRNA vaccines against novel coronavirus infection 达冕生物有限公司 2024-05-31 CN disclosed
CN-118099177-A Integrated photodetector with direct combined pixels 宽腾矽公司 2024-05-28 CN disclosed
US-20240156947-A1 COMPOSITION AND METHODS FOR MRNA VACCINES AGAINST NOVEL OMICRON CORONAVIRUS INFECTIONS RNAimmune, Inc. (US) 2024-05-16 US disclosed
WO-2024097259-A1 COMPOSITION AND METHODS FOR MRNA VACCINES AGAINST NOVEL OMICRON CORONAVIRUS INFECTIONS RNAimmune, Inc. (US) 2024-05-10 WO disclosed
WO-2024097894-A1 COMPOSITIONS AND METHODS OF RIBONUCLEIC ACID VACCINES ENCODING NYE-SO-1 RNAimmune, Inc. (US) 2024-05-10 WO disclosed
EP-4351615-A2 MULTIPLEXED TP53 AND PAN-RAS MRNA CANCER VACCINES Rnaimmune, Inc. (US) 2024-04-17 EP disclosed
US-6495671-B1 Oligonucleotide and nucleotide amine analogs, methods of synthesis and use ISIS PHARMACEUTICALS, INC. 2002-12-17 US disclosed
US-20020187479-A1 In vitro capture of nucleic acids via modified oligonucleotides and magnetic beads SYNGENTA PARTICIPATIONS AG (CH) 2002-12-12 US disclosed
US-6403314-B1 PREDICTING, ANALYZING, AND STORING STABILITIES; DATA PROCESSING AGILENT TECHNOLOGIES, INC. 2002-06-11 US disclosed
EP-1206580-A1 IMPROVED METHOD FOR NUCLEOTIDE DETECTION AND DEVICES USED THEREIN Dot Diagnostics B.V. (NL) 2002-05-22 EP disclosed
US-6235886-B1 OLIGONUCLEOTIDES ISIS PHARMACEUTICALS, INC. 2001-05-22 US disclosed
WO-2001018241-A1 IMPROVED METHOD FOR NUCLEOTIDE DETECTION AND DEVICES USED THEREIN DOT DIAGNOSTICS B.V. (NL) 2001-03-15 WO disclosed
US-5906918-A QUANTITATING BASE MODIFICATIONS IN SAMPLE DNA BY ENDONUCLEASE DIGESTION TO DINUCLEOSIDE MONOPHOSPHATES, DEPHOSPHORYLATION, LABELING SAMPLE AND INTERNAL STANDARD DNA, ADDING COMIGRATING CARRIERS, SEPARATING SAMPLE/CARRIER FROM STANDARD/CARRIER HEALTH RESEARCH INC. (US) 1999-05-25 US disclosed
US-5834607-A FOR ENHANCED CELLULAR UPTAKE OF OLIGONUCLEOTIDES; ANTISENSE THERAPY ISIS PHARMACEUTICALS, INC. (US) 1998-11-10 US disclosed
US-5591841-A REVERSIBLY FORMING A TRIPLE STRANDED STRUCTURE, ELIMINATES NEED FOR DENATURING UNITED STATES DEPARTMENT OF ENERGY 1997-01-07 US disclosed
WO-1994006815-A1 OLIGONUCLEOTIDE AND NUCLEOTIDE AMINE ANALOGS, METHODS OF SYNTHESIS AND USE ISIS PHARMACEUTICALS, INC. (US) 1994-03-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240156947-A1 COMPOSITION AND METHODS FOR MRNA VACCINES AGAINST NOVEL OMICRON CORONAVIRUS INFECTIONS RBM22, RNGTT, RBM25 ATAD2 3454/4885DPYD 4273/4885ALDH1A1 4880/4885
US-20240226275-A1 COMPOSITIONS AND METHODS OF MRNA VACCINES AGAINST NOVEL CORONAVIRUS INFECTION RNGTT, SARS1, ACE2 ATAD2 3075/4885DPYD 3228/4885ALDH1A1 4884/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.