ATP2A3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL38604	1.00	1/20
Thapsigargin (SCHEMBL82423)	1.00	1/20
Paxilline (SCHEMBL361232)	1.00	1/20
SCHEMBL1471247	1.00	1/20
Thapsigargin (SCHEMBL5690389)	1.00	1/20
Paxilline (SCHEMBL5955728)	1.00	1/20
SCHEMBL7647492	0.88	1/20
SCHEMBL8609578	0.88	1/20
Debutanoylthapsigargin (SCHEMBL2623705)	0.84	1/20
SCHEMBL67854	0.82	1/20
SCHEMBL6355084	0.77	1/20
SCHEMBL627857	0.75	1/20
SCHEMBL3518869	0.75	1/20
SCHEMBL5470246	0.75	1/20
SCHEMBL2623706	0.74	1/20
SCHEMBL395984	0.70	1/20
SCHEMBL1273953	0.68	1/20
E319 (SCHEMBL2137723)	0.68	1/20
SCHEMBL2485961	0.68	1/20
SCHEMBL3628725	0.68	1/20

Clinical trials — most relevant to ATP2A3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Magnesium Administration in Liver Transplantation and Reperfusion Injury	PHASE4	COMPLETED
Levosimendan in Acute Decompensated Heart Failure	PHASE2/PHASE3	NOT_YET_RECRUITING
Role of Intralipid in Management of Organophosphorus Poisoning	PHASE2/PHASE3	WITHDRAWN
Empagliflozin in Hypertrophic Cardiomyopathy	PHASE3	ACTIVE_NOT_RECRUITING
Renal Transplantation and Inhaled Anesthetic Sevoflurane (SEVOREIN)	PHASE3	COMPLETED
PHOspholamban RElated CArdiomyopathy STudy - Intervention	PHASE3	COMPLETED
Targeting Endoplasmic Reticulum Stress in Human Hypertension	PHASE1/PHASE2	RECRUITING
S 48168 (ARM 210) for the Treatment of RYR1-related Myopathies (RYR1-RM)	PHASE1	COMPLETED
Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival	PHASE1	UNKNOWN
Modulation of SERCA2a of Intra-Myocytic Calcium Trafficking in Cardiomyopathy Secondary to Duchenne Muscular Dystrophy	PHASE1	RECRUITING
Hemodynamic Response to Exercise in HFpEF Patients After Upregulation of SERCA2a	EARLY_PHASE1	COMPLETED
Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) in Ischaemic, Inflammatory and Takotsubo Cardiomyopathy (MEMORY)	nan	COMPLETED
Role of Amino Acids and Genetic Disorder in Pathogenesis of Heart Failure	nan	UNKNOWN
Calcium Handling and Epicardial Ablation	nan	COMPLETED
Evaluation of A Clinical Diagnostic Test for CRDS	nan	RECRUITING
Ventricular Arrhythmias in Uremic Cardiomyopathy	nan	COMPLETED
Early Detection of Cardiomyopathy by Speckle Echo, High Sensitive Troponin and Cardiac Ryanodine Receptors	nan	UNKNOWN
Wolfram Syndrome and WFS1-related Disorders International Registry and Clinical Study	nan	RECRUITING
Carnosine Supplementation on Quantity/Quality of Oral Salivae.	nan	UNKNOWN
Evaluate the Effort Test as a Therapeutic Monitoring Tool in Acute Rhabdomyolyses	nan	COMPLETED
Predicting Pancreatic Necrosis Using mitDNA	nan	UNKNOWN
Heart and Skeletal Muscle Problems in Neuroacanthocytosis	nan	COMPLETED
The Prevalence of RYR1-related Disease	nan	NOT_YET_RECRUITING
Characterization of Obesity-related Cardiomyopathy Through Exploration of Human Atrial Trabeculae Contraction	nan	COMPLETED
The Energetic Origin of Neurodegeneration in MS	nan	COMPLETED
Recovery From 50 Eccentric Biceps Curls in Young, Untrained Men and Women	nan	COMPLETED
Cardiac Contractility Modulation Therapy in Amyloid Cardiomyopathy Patients With Heart Failure	nan	UNKNOWN
A Novel Technique Of Uterine Cooling During Repeated Cesarean Section For Reducing Blood Loss	nan	COMPLETED
Population at Risk of Malignant Hyperthermia: Ambispective Cohort.	nan	UNKNOWN
Uterine Cooling During Cesarean Delivery to Reduce Blood Loss and Incidence of Postpartum Hemorrhage	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ATP2A3 binder may also engage these)

Protein	Name	Similarity
P18596	—	1.000	P18596 →
Q64518	—	1.000	Q64518 →
O77696	—	1.000	O77696 →
Q64578	—	0.999	Q64578 →
Q7PPA5	—	0.999	Q7PPA5 →
Q8R429	—	0.999	Q8R429 →
P04191	—	0.998	P04191 →
ATP2A1	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0.998	landscape →
P13585	—	0.997	P13585 →
P70083	—	0.997	P70083 →
P20647	—	0.996	P20647 →
P11607	—	0.995	P11607 →
Q9YGL9	—	0.995	Q9YGL9 →
P11507	—	0.995	P11507 →
Q0VCY0	—	0.995	Q0VCY0 →
ATP2A2	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0.995	landscape →
P22700	—	0.995	P22700 →
P35316	—	0.994	P35316 →
Q92105	—	0.993	Q92105 →
ATP4A	Potassium-transporting ATPase alpha chain 1 (	0.993	landscape →
O55143	—	0.993	O55143 →
Q292Q0	—	0.993	Q292Q0 →
Q7ZW18	—	0.993	Q7ZW18 →
Q03669	—	0.992	Q03669 →
Q9SY55	—	0.992	Q9SY55 →
O46674	—	0.992	O46674 →
P54209	—	0.991	P54209 →
Q00779	—	0.991	Q00779 →
Q2RAS0	—	0.991	Q2RAS0 →
P35315	—	0.991	P35315 →