Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 17/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | ATXN2 | Q99700 | 12/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL107531 | 0.93 | ENPP2 (0.47) | ENPP2KCNH2ATXN2 | |
| SCHEMBL1671586 | 0.92 | ENPP2 (0.48) | ENPP2KCNH2ATXN2 | |
| SCHEMBL1670435 | 0.89 | ENPP2 (0.43) | ENPP2KCNH2ATXN2 | |
| SCHEMBL13137773 | 0.88 | ENPP2 (0.70) | ENPP2KCNH2ATXN2 | |
| SCHEMBL104876 | 0.88 | ENPP2 (0.70) | ENPP2KCNH2ATXN2 | |
| SCHEMBL13137772 | 0.88 | ENPP2 (0.70) | ENPP2KCNH2ATXN2 | |
| SCHEMBL1672873 | 0.86 | ENPP2 (0.42) | ENPP2KCNH2ATXN2 | |
| SCHEMBL104770 | 0.81 | ENPP2 (0.61) | ENPP2KCNH2ATXN2 | |
| SCHEMBL11967643 | 0.81 | ENPP2 (0.36) | ENPP2KCNH2ATXN2 | |
| SCHEMBL104128 | 0.81 | ENPP2 (0.65) | ENPP2KCNH2ATXN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426106-B1 | Piperidine and Piperazine derivatives for the treatment of tumours | MERCK PATENT GMBH (DE) | 2013-07-31 | — | — | EP | claimed |
| EP-2426106-B1 | Piperidine and Piperazine derivatives for the treatment of tumours | MERCK PATENT GMBH (DE) | 2013-07-31 | — | — | EP | disclosed |
| EP-2426106-A1 | Piperidine and Piperazine derivatives for the treatment of tumours | Merck Patent GmbH (DE) | 2012-03-07 | — | — | EP | disclosed |