BAG3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL21783176	0.82	1/20
SCHEMBL21783153	0.77	1/20
SCHEMBL21783145	0.74	1/20
SCHEMBL20534277	0.72	1/20
SCHEMBL20534278	0.72	1/20
SCHEMBL21783131	0.72	1/20
SCHEMBL21783142	0.71	1/20
SCHEMBL21783164	0.71	1/20
SCHEMBL21783171	0.71	1/20
SCHEMBL21783127	0.71	1/20
SCHEMBL28374629	0.71	1/20
SCHEMBL21783144	0.71	1/20
SCHEMBL20534465	0.70	1/20
SCHEMBL20534466	0.70	1/20
SCHEMBL21783143	0.70	1/20
SCHEMBL21783184	0.70	1/20
SCHEMBL22092306	0.70	1/20
SCHEMBL20534409	0.69	1/20
SCHEMBL20534411	0.69	1/20
SCHEMBL21783136	0.69	1/20

Clinical trials — most relevant to BAG3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Liraglutide on ER Stress in Obese Patients With Type 2 Diabetes	PHASE4	UNKNOWN
ALXN2350 in Adult Participants With BAG3-Associated Dilated Cardiomyopathy	PHASE1/PHASE2	RECRUITING
Targeting Endoplasmic Reticulum Stress in Human Hypertension	PHASE1/PHASE2	RECRUITING
Belimumab Treatment of Emphysema Patients With Anti-GRP78 Autoantibodies	PHASE2	COMPLETED
OGX-427 in Castration Resistant Prostate Cancer Patients	PHASE2	COMPLETED
Efficacy and Safety Assessment of Oral LBH589 in Adult Patients With Advanced Soft TIssue Sarcoma After Pre-treatment Failure	PHASE2	COMPLETED
Ambroxol Therapy for Patients With Type 1 Gaucher Disease and Suboptimal Response to Enzyme Replacement Therapy	PHASE2	COMPLETED
Colchicine for Amyotrophic Lateral Sclerosis	PHASE2	COMPLETED
Targeting the Tumor Microenvironment in R/M SCCHN	PHASE1/PHASE2	UNKNOWN
Biologic Correlative Taxotere/AC	PHASE2	COMPLETED
A Phase 1 AAV Gene Therapy Trial Evaluating Safety and Preliminary Efficacy of RP-A701 in Subjects With BAG3 Dilated Cardiomyopathy	PHASE1	RECRUITING
Study of Oral CNF2024 (BIIB021) in Advanced Solid Tumors	PHASE1	COMPLETED
Safety and Pharmacology of SNX-5422 Plus Carboplatin and Paclitaxel in Subjects With Solid Tumors	PHASE1	COMPLETED
SNX-5422 to Treat Solid Tumor Cancers and Lymphomas	PHASE1	COMPLETED
Phase I Dose Finding and Proof-of-concept Study of Panobinostat With Standard Dose Cytarabine and Daunorubicin for Untreated Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome	PHASE1	COMPLETED
Safety Study of IPI-504 in Patients With Relapsed and Relapsed Refractory Multiple Myeloma	PHASE1	COMPLETED
Observational Study of Natural History of BAG3 Gene Mutation-Associated Dilated Cardiomyopathy in Chinese Adults	nan	NOT_YET_RECRUITING
A Study About the Natural History in Adults With BAG3 Dilated Cardiomyopathy (a Type of Heart Disease) (BAG3 DCM)	nan	ACTIVE_NOT_RECRUITING
BAG3-DCM Natural History Study	nan	NOT_YET_RECRUITING
Establishment of Human Cellular Disease Models for Wilson Disease	nan	COMPLETED
Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)	nan	RECRUITING
LncRNA Nicotinamide Nucleotide Transhydrogenase-Antisense RNA1 NNT-AS1 in CRC	nan	COMPLETED
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia	nan	RECRUITING
Proteomic Analysis of Serum Samples After Cardiac Arrest: a TTM-trial Substudy	nan	ACTIVE_NOT_RECRUITING
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Exercise on Expression of Heat Shock Protein 70 in Arterial Risk	nan	COMPLETED
Diagnostic Potential of UCHL1 in Acute Decompensated Heart Failure	nan	COMPLETED
Idiopathic Dilated Cardiomyopathy	nan	COMPLETED
Role of Sorcin and Annexin A3 in Breast Cancer Patients	nan	UNKNOWN
Autophagy Bladder Cancer	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a BAG3 binder may also engage these)

Protein	Name	Similarity
Q9JLV1	—	1.000	Q9JLV1 →
Q2EJA0	—	0.997	Q2EJA0 →
A0A8C0NGY6	—	0.996	A0A8C0NGY6 →
P29172	—	0.996	P29172 →
Q62901	—	0.996	Q62901 →
Q86TC9	—	0.996	Q86TC9 →
Q5RAU1	—	0.996	Q5RAU1 →
Q5XHF3	—	0.995	Q5XHF3 →
Q9XTT4	—	0.995	Q9XTT4 →
Q7ZXH3	—	0.995	Q7ZXH3 →
Q5HZJ0	—	0.995	Q5HZJ0 →
Q6NZJ6	—	0.994	Q6NZJ6 →
P53814	—	0.994	P53814 →
Q9Y2H5	—	0.994	Q9Y2H5 →
Q9BG89	—	0.994	Q9BG89 →
Q6PEI3	—	0.994	Q6PEI3 →
Q1L8J7	—	0.994	Q1L8J7 →
F1QIC4	—	0.994	F1QIC4 →
P48436	—	0.994	P48436 →
P61753	—	0.994	P61753 →
B1AZP2	—	0.994	B1AZP2 →
Q7YRJ7	—	0.994	Q7YRJ7 →
Q8K0V4	—	0.994	Q8K0V4 →
Q5TZ18	—	0.993	Q5TZ18 →
Q80TN7	—	0.993	Q80TN7 →
H2LBU8	—	0.993	H2LBU8 →
Q2LC84	—	0.993	Q2LC84 →
Q91XT4	—	0.993	Q91XT4 →
Q9BLJ6	—	0.993	Q9BLJ6 →
P0C1X8	—	0.993	P0C1X8 →