Sugi Predict

Sugi Predict / Targets / COG3

COG3

Conserved oligomeric Golgi complex subunit 3 · Q96JB2 · COG3 on Sugi Atlas →

0 patent compounds predicted against COG3, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to COG3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
A Safety and Efficacy Study of Fabrazyme® Replacement Therapy in Patients With Cardiac Fabry Disease PHASE4COMPLETED
Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD PHASE3COMPLETED
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47) PHASE1/PHASE2NOT_YET_RECRUITING
An Open-label Safety, Pharmacokinetic, and Efficacy Study of Miglustat for the Treatment of Subjects With Batten Ceroid Lipofuscinosis, Neuronal 3 (CLN3) Disease PHASE1/PHASE2COMPLETED
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
Intrathecal Administration of scAAV9/JeT-GAN for the Treatment of Giant Axonal Neuropathy PHASE1COMPLETED
Glutamine Supplementation in People With Immune Dysregulation EARLY_PHASE1WITHDRAWN
Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing nanCOMPLETED
Investigations of Juvenile Neuronal Ceroid Lipofuscinosis nanRECRUITING
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
Evaluation of Limb-Girdle Muscular Dystrophy nanCOMPLETED
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM) nanCOMPLETED
Cognitive Neurology Unit Clinical Registry nanRECRUITING
Registry Gangliosidoses nanUNKNOWN
A Patient-tailored Genetic/Biomarker/iPSC Combined Approach in ALS - PERMEALS nanRECRUITING
Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) nanCOMPLETED
Role of Polymorphisms in the IL-1 Gene Cluster nanCOMPLETED
Identification of New FTLD Genes nanUNKNOWN
Molecular Genetic Study of Schizophrenia: Parent-Offspring Trios nanCOMPLETED
Pediatric Evaluation and Registry for Liver Cholestasis in Canada nanRECRUITING
Genetic Characterization of Parkinson's Disease nanCOMPLETED
A Study on Risk Mutations of Vulnerability Genes of Schizophrenia nanUNKNOWN
Transforming Research and Clinical Knowledge in Traumatic Brain Injury nanCOMPLETED
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH) nanCOMPLETED
Identification of Genetic Basis of Atrioventricular Conduction Defects: From Congenital Forms to Degenerative Forms nanUNKNOWN
Exome Analysis in Hearing Impaired Patients nanUNKNOWN
Identification of a New Gene Involved in Hereditary Lipodystrophy nanCOMPLETED
Investigations Into ISCU Myopathy or Iron Sulfur Scaffold U Protein Myopathy nanCOMPLETED
Genetic Analysis of Gray Platelet Syndrome nanCOMPLETED
GNAO1 Natural History Study nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a COG3 binder may also engage these)

ProteinNameSimilarity
Q8CI04 — 1.000 Q8CI04 →
Q8MSY4 — 0.996 Q8MSY4 →
F4HQ84 — 0.996 F4HQ84 →
Q16ZN9 — 0.995 Q16ZN9 →
Q921L5 — 0.993 Q921L5 →
Q0V8C2 — 0.992 Q0V8C2 →
Q961G1 — 0.992 Q961G1 →
EXOC3 Exocyst complex component 3 0.991 landscape →
Q6NMI3 — 0.990 Q6NMI3 →
Q9V564 — 0.989 Q9V564 →
Q9JJA2 — 0.989 Q9JJA2 →
Q8L838 — 0.989 Q8L838 →
Q29N70 — 0.988 Q29N70 →
A2VDR8 — 0.988 A2VDR8 →
Q9V8K2 — 0.987 Q9V8K2 →
COG2 Conserved oligomeric Golgi complex subunit 2 0.987 landscape →
Q9VVG4 — 0.987 Q9VVG4 →
Q9FVV6 — 0.987 Q9FVV6 →
O54922 — 0.986 O54922 →
Q2TBH9 — 0.986 Q2TBH9 →
O94915 — 0.986 O94915 →
Q8C0L8 — 0.986 Q8C0L8 →
Q7ZX96 — 0.985 Q7ZX96 →
Q3UM29 — 0.985 Q3UM29 →
Q5U247 — 0.985 Q5U247 →
A2VE70 — 0.984 A2VE70 →
TUBGCP2 Gamma-tubulin complex component 2 0.984 landscape →
P34561 — 0.984 P34561 →
Q29RB1 — 0.984 Q29RB1 →
Q80TJ1 — 0.983 Q80TJ1 →