Sugi Predict

Sugi Predict / Targets / COG2

COG2

Conserved oligomeric Golgi complex subunit 2 · Q14746 · COG2 on Sugi Atlas →

0 patent compounds predicted against COG2, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to COG2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47) PHASE1/PHASE2NOT_YET_RECRUITING
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
A Phase 1/2 Study of Intravenous Gene Transfer With an AAV9 Vector Expressing Human Beta-galactosidase in Type I and Type II GM1 Gangliosidosis PHASE1/PHASE2RECRUITING
Glutamine Supplementation in People With Immune Dysregulation EARLY_PHASE1WITHDRAWN
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM) nanCOMPLETED
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study) nanCOMPLETED
Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing nanCOMPLETED
Molecular Genetic Study of Schizophrenia: Parent-Offspring Trios nanCOMPLETED
Protein Synthesis in the Brain of Patients With Fragile X Syndrome nanCOMPLETED
Registry Gangliosidoses nanUNKNOWN
Genetic Characterization of Parkinson's Disease nanCOMPLETED
Cognitive Neurology Unit Clinical Registry nanRECRUITING
Non Motor Symptoms in Glucocerebrosidase-related Parkinson's Disease nanENROLLING_BY_INVITATION
Identification of a New Gene Involved in Hereditary Lipodystrophy nanCOMPLETED
Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) nanCOMPLETED
Pediatric Evaluation and Registry for Liver Cholestasis in Canada nanRECRUITING
Identification of New FTLD Genes nanUNKNOWN
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
MEHMO Natural History and Biomarkers nanRECRUITING
Genetic Analysis of Gray Platelet Syndrome nanCOMPLETED
A Study on Risk Mutations of Vulnerability Genes of Schizophrenia nanUNKNOWN
Evaluation of Systemic and Oral Conditions of Pregnant Women and Their Babies, With Exposure to COVID-19 Infection nanUNKNOWN
Genetic Studies of Lysosomal Storage Disorders nanENROLLING_BY_INVITATION
Glycosylation in Patients With Galactosaemia nanCOMPLETED
Clinical Importance of Carrier Status of Recessive Gene Mutations in Myopathy (CICS) nanUNKNOWN
Investigations Into ISCU Myopathy or Iron Sulfur Scaffold U Protein Myopathy nanCOMPLETED
Use of miRNAs in Growth Hormone Deficiency (GHD) nanUNKNOWN
Natural History of Limb Girdle Muscular Dystrophy Type 2A and Type 2E nanCOMPLETED
Defining Clinical Endpoints in Limb Girdle Muscular Dystrophy (LGMD) nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a COG2 binder may also engage these)

ProteinNameSimilarity
Q921L5 — 1.000 Q921L5 →
Q6NMI3 — 0.997 Q6NMI3 →
COG7 Conserved oligomeric Golgi complex subunit 7 0.997 landscape →
Q8CI04 — 0.996 Q8CI04 →
F4JRR1 — 0.995 F4JRR1 →
F4HQ84 — 0.994 F4HQ84 →
COG5 Conserved oligomeric Golgi complex subunit 5 0.993 landscape →
EXOC3 Exocyst complex component 3 0.993 landscape →
Q9JJA2 — 0.992 Q9JJA2 →
Q0V8C2 — 0.992 Q0V8C2 →
Q8MSY4 — 0.991 Q8MSY4 →
Q3T1G7 — 0.991 Q3T1G7 →
F4JHH5 — 0.991 F4JHH5 →
Q6KAR6 — 0.991 Q6KAR6 →
Q6PGF7 — 0.991 Q6PGF7 →
Q5U247 — 0.990 Q5U247 →
Q3UM29 — 0.990 Q3UM29 →
A2VDR8 — 0.989 A2VDR8 →
O54922 — 0.989 O54922 →
O35250 — 0.989 O35250 →
Q9LXX6 — 0.989 Q9LXX6 →
COG3 Conserved oligomeric Golgi complex subunit 3 0.988 landscape →
Q8C0L8 — 0.988 Q8C0L8 →
Q8L838 — 0.988 Q8L838 →
Q9VBY8 — 0.988 Q9VBY8 →
Q9V8K2 — 0.988 Q9V8K2 →
Q29N70 — 0.987 Q29N70 →
A4IF89 — 0.987 A4IF89 →
Q62825 — 0.987 Q62825 →
Q961G1 — 0.987 Q961G1 →