COL2A1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL22066306	1.00	1/20
SCHEMBL22066290	0.83	1/20
SCHEMBL22066305	0.75	1/20
SCHEMBL22066297	0.72	1/20
SCHEMBL22066285	0.70	1/20
SCHEMBL22066282	0.68	1/20
SCHEMBL22066409	0.68	1/20
SCHEMBL22066410	0.68	1/20
SCHEMBL22067547	0.68	1/20
SCHEMBL22066283	0.65	1/20
SCHEMBL22066303	0.65	1/20
SCHEMBL22066304	0.65	1/20
SCHEMBL22067608	0.65	1/20
SCHEMBL22066411	0.52	1/20
SCHEMBL31087188	0.43	1/20
SCHEMBL2558295	0.41	1/20
SCHEMBL2562297	0.41	1/20

Clinical trials — most relevant to COL2A1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
5FU vs 5FU With Viscoelastic Formulation for the Prevention of Scarring Post-trabeculectomy	PHASE4	COMPLETED
Effect of Dapagliflozin on Renal Outcomes and Bone Mineral Disease in Non-diabetic Chronic Kidney Disease Patients	PHASE4	COMPLETED
Clinical and Therapeutic Implications of Fibrosis in Hypertrophic Cardiomyopathy	PHASE4	COMPLETED
Pamidronate to Treat Osteogenesis Imperfecta in Children	PHASE3	COMPLETED
Setrusumab in Pediatric Japanese Subjects With Osteogenesis Imperfecta	PHASE3	ACTIVE_NOT_RECRUITING
Efficacy and Safety of Neridronate (Nerixia®)to Treat Osteoporosis in Patients With TM and TI	PHASE2	COMPLETED
Personalised Prospective Comparison of ARni With ArB in Patients With Natriuretic Peptide eLEvation	PHASE2	UNKNOWN
Oral Collagen for Rheumatoid Arthritis	PHASE2	COMPLETED
Study to Evaluate Pharmacokinetics, Safety, and Tolerability Ildong COL-144 Tablet in Korean Healthy Volunteers	PHASE1	UNKNOWN
Long-Term Effects of Mobithron Advance on Knee Osteoarthritis Aims to Investigate the Effects of Mobithron Advance on OA Progression	EARLY_PHASE1	RECRUITING
Telescoping Nail in Osteogenesis Imperfecta	nan	ACTIVE_NOT_RECRUITING
Pediatric Arthropathy Beyond Inflammation: Clinical Spectrum and Diagnostic Approach at Assiut University Children Hospital	nan	NOT_YET_RECRUITING
Clear Aligners for the Treatment of Dental Malocclusion in OI	nan	ACTIVE_NOT_RECRUITING
Epigenetic Regulation of Osteogenesis Imperfecta Severity : miROI Study	nan	COMPLETED
Resistance Exercise and Hydrolyzed Collagen Supplementation	nan	COMPLETED
Osteogenesis Imperfecta Blood Pressure Study	nan	COMPLETED
Cartilage Tissue Engineering	nan	AVAILABLE
Acute Resistance Exercise and Hydrolyzed Collagen Supplementation	nan	COMPLETED
Natural History of the Collagen-Related Disorder Osteogenesis Imperfecta and Genotype Phenotype Correlation	nan	COMPLETED
Identification of Biochemical and Biomechanical Markers for Cartilage Degeneration in the Knee Joint (IBBM-CKJ)	nan	UNKNOWN
Clinical Study on the Application of PET Probes Targeting DDR2 in the Diagnosis of Interstitial Lung Disease With Cognitive Impairment	nan	NOT_YET_RECRUITING
Effect of Thiazolidinediones on Human Bone	nan	COMPLETED
Impact of the Source and Food Matrices on the Bioavailability of Peptan® (Collagen Peptides) in Healthy Subjects	nan	COMPLETED
Effects Of Native Collagen Type 2 Treatment	nan	COMPLETED
Effects of a Dietary Supplement on Collagen Production and Evaluation of Its Regenerative and Anti-Ageing Propertiess	nan	COMPLETED
Fibroblast Line Evaluation for COL5A eXpression and Thoracic Aortic Aneurysms: in Vitro Characterization of Cutaneous Fibroblasts in Adult Patients	nan	NOT_YET_RECRUITING
Evaluation of Different Serum Cartilage Biomarkers in the Acute Response to Walking and Cycling in Healthy Male Subjects	nan	AVAILABLE
Effects of UC-II, Glucosamine and Curcumin Supplementation on Knee Pain and Inflammation.	nan	COMPLETED
Serum Anti-PCOLCE as Novel Diagnostic Biomarker in Rheumatoid Arthritis With Emphasis on Seronegative Patients.	nan	NOT_YET_RECRUITING
Effects of Vitamin C Enriched Hydrolyzed Collagen, PrimaColl™, Whey Protein, or Placebo on Collagen Synthesis	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a COL2A1 binder may also engage these)

Protein	Name	Similarity
P11087	—	1.000	P11087 →
Q9XSJ7	—	1.000	Q9XSJ7 →
Q6P4Z2	—	1.000	Q6P4Z2 →
P02459	—	1.000	P02459 →
COL1A1	Collagen alpha-1(I) chain	1.000	landscape →
P28481	—	1.000	P28481 →
P02457	—	1.000	P02457 →
P05539	—	0.998	P05539 →
Q91717	—	0.996	Q91717 →
C0HLG9	—	0.996	C0HLG9 →
P02453	—	0.996	P02453 →
C0HLI1	—	0.996	C0HLI1 →
P02454	—	0.996	P02454 →
C0HLG7	—	0.996	C0HLG7 →
C0HLH3	—	0.994	C0HLH3 →
C0HM93	—	0.993	C0HM93 →
C0HLI9	—	0.992	C0HLI9 →
C0HLJ9	—	0.992	C0HLJ9 →
C0HLJ3	—	0.991	C0HLJ3 →
Q9YIB4	—	0.991	Q9YIB4 →
C0HJP3	—	0.990	C0HJP3 →
P02461	—	0.990	P02461 →
C0HLI7	—	0.990	C0HLI7 →
P0C2W8	—	0.989	P0C2W8 →
C0HJP7	—	0.989	C0HJP7 →
C0HLI3	—	0.989	C0HLI3 →
C0HLH5	—	0.989	C0HLH5 →
C0HLJ5	—	0.989	C0HLJ5 →
C0HLI5	—	0.988	C0HLI5 →
C0HLJ1	—	0.988	C0HLJ1 →