COX5B — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to COX5B by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease	PHASE3	COMPLETED
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
Clinical Evaluation of the Effect of Metformin in Sepsis	PHASE3	UNKNOWN
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
Relative Mitochondrial Toxicity of Tenofovir Alafenamide (TAF) vs. Tenofovir Disoproxil Fumarate (TDF)	PHASE1/PHASE2	COMPLETED
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)?	PHASE1	UNKNOWN
Plasma Cytochrome c as Biomarker of Traumatic Injury and Predictor of Outcome	nan	COMPLETED
The Crosstalk Between the Epigenome and Mitochondria in SCI	nan	NOT_YET_RECRUITING
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Ultrastructural Characteristics of Mitochondria in Cardiomyocytes in Heart Failure	nan	RECRUITING
Collection of Blood and Skin Samples From Patients With Primary Mitochondrial Diseases and Healthy Volunteers	nan	RECRUITING
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine	nan	COMPLETED
The Genetics of Diabetes in Southern California Chinese Americans	nan	WITHDRAWN
Mitochondrial Methylation in Type 2 Diabetes	nan	COMPLETED
Reactive Oxygen Species Following Aortic Valve Replacement	nan	COMPLETED
Natural History in Primary Mitochondrial Myopathies	nan	RECRUITING
Cardiac Mitochondrial Function in Explanted Human Hearts	nan	UNKNOWN
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy	nan	COMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
The Fuel and Rhythm (FAR) Phase 2 Study	nan	COMPLETED
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability.	nan	UNKNOWN
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
Mitoquines in COPD	nan	UNKNOWN
Mitochondrial Function of Immune Cells in Sepsis	nan	COMPLETED
The Natural History of Mitochondrial Diseases	nan	RECRUITING
Effects of Acute Energy Deficit and Aerobic Exercise on Muscle Quality	nan	COMPLETED
A Feasibility Study: Assessing Photobiomodulation in Myalgic Encephalomyelitis	nan	UNKNOWN
Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy	nan	RECRUITING
Exercise and Nutritional Supplementation	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a COX5B binder may also engage these)

Protein	Name	Similarity
Q5REG2	—	1.000	Q5REG2 →
P12075	—	1.000	P12075 →
P00428	—	1.000	P00428 →
Q5S3G4	—	0.998	Q5S3G4 →
P19536	—	0.997	P19536 →
Q710D6	—	0.990	Q710D6 →
P79010	—	0.988	P79010 →
P00258	—	0.985	P00258 →
Q93Y52	—	0.984	Q93Y52 →
O74988	—	0.984	O74988 →
B0VYX6	—	0.984	B0VYX6 →
P12787	—	0.984	P12787 →
Q5EU90	—	0.984	Q5EU90 →
B0VYY1	—	0.983	B0VYY1 →
B4LKE5	—	0.983	B4LKE5 →
A8P488	—	0.983	A8P488 →
Q53CG1	—	0.983	Q53CG1 →
A3KMZ6	—	0.983	A3KMZ6 →
B0VYX8	—	0.983	B0VYX8 →
B0VYY2	—	0.983	B0VYY2 →
B0VYX7	—	0.982	B0VYX7 →
COX5A	Cytochrome c oxidase subunit 5A, mitochondrial	0.982	landscape →
Q19724	—	0.982	Q19724 →
Q04907	—	0.982	Q04907 →
P83483	—	0.982	P83483 →
P00426	—	0.981	P00426 →
B0VYY5	—	0.981	B0VYY5 →
B5DKJ8	—	0.981	B5DKJ8 →
B4K5X8	—	0.981	B4K5X8 →
Q8RXN5	—	0.981	Q8RXN5 →