COX6A1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to COX6A1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease	PHASE3	COMPLETED
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
Clinical Evaluation of the Effect of Metformin in Sepsis	PHASE3	UNKNOWN
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)?	PHASE1	UNKNOWN
Plasma Cytochrome c as Biomarker of Traumatic Injury and Predictor of Outcome	nan	COMPLETED
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine	nan	COMPLETED
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
The Natural History of Mitochondrial Diseases	nan	RECRUITING
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability.	nan	UNKNOWN
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders	nan	COMPLETED
Natural History in Primary Mitochondrial Myopathies	nan	RECRUITING
The Genetics of Diabetes in Southern California Chinese Americans	nan	WITHDRAWN
Acute Infection in Mitochondrial Disease: Metabolism, Infection and Immunity	nan	RECRUITING
Diagnostic Odyssey Survey 2	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
The Crosstalk Between the Epigenome and Mitochondria in SCI	nan	NOT_YET_RECRUITING
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy	nan	COMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
Effect of Diaphragm Stimulation During Surgery	nan	COMPLETED
Effects of Acute Energy Deficit and Aerobic Exercise on Muscle Quality	nan	COMPLETED
Clinical Study of Hydroxytyrosol (HT) in Mitochondrial Diseases	nan	COMPLETED
mtDNA Mutation Load Analysis in Mesoangioblasts	nan	RECRUITING
Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy	nan	RECRUITING
Collection of Blood and Skin Samples From Patients With Primary Mitochondrial Diseases and Healthy Volunteers	nan	RECRUITING
Ultrastructural Characteristics of Mitochondria in Cardiomyocytes in Heart Failure	nan	RECRUITING
An Observational Study of Patients With Primary Mitochondrial Disease (SPIMM-300)	nan	COMPLETED
Mitoquines in COPD	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a COX6A1 binder may also engage these)

Protein	Name	Similarity
Q9TTT7	—	1.000	Q9TTT7 →
P10818	—	0.996	P10818 →
P43024	—	0.995	P43024 →
P13182	—	0.988	P13182 →
O13082	—	0.982	O13082 →
P43023	—	0.979	P43023 →
P10817	—	0.979	P10817 →
Q5RC38	—	0.976	Q5RC38 →
P07471	—	0.973	P07471 →
Q02221	—	0.971	Q02221 →
O13085	—	0.970	O13085 →
Q4FZG9	—	0.967	Q4FZG9 →
COXFA4	Cytochrome c oxidase subunit NDUFA4	0.962	landscape →
Q0MQC8	—	0.961	Q0MQC8 →
Q9T070	—	0.960	Q9T070 →
Q0MQ97	—	0.960	Q0MQ97 →
Q5REX0	—	0.959	Q5REX0 →
Q5R9K2	—	0.959	Q5R9K2 →
Q3SZ44	—	0.959	Q3SZ44 →
NDUFB2	NADH dehydrogenase [ubiquinone] 1 beta subcom	0.957	landscape →
Q96KF7	—	0.957	Q96KF7 →
P24311	—	0.956	P24311 →
P00125	—	0.955	P00125 →
Q8TF08	—	0.955	Q8TF08 →
Q9D0M3	—	0.955	Q9D0M3 →
COXFA4L2	Cytochrome c oxidase hypoxia associated subun	0.955	landscape →
Q0MQ98	—	0.955	Q0MQ98 →
Q9FGK0	—	0.954	Q9FGK0 →
Q0MQC7	—	0.954	Q0MQC7 →
Q01321	—	0.954	Q01321 →