Sugi Predict

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CRH

Corticoliberin · P06850 · CRH on Sugi Atlas →

9 patent compounds predicted against CRH, 9 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL6070464 SCHEMBL6070464 0.59 1/20
SCHEMBL6069992 SCHEMBL6069992 0.53 1/20
SCHEMBL6069631 SCHEMBL6069631 0.46 1/20
SCHEMBL6071429 SCHEMBL6071429 0.46 1/20
SCHEMBL6070559 SCHEMBL6070559 0.44 1/20
SCHEMBL6070921 SCHEMBL6070921 0.42 1/20
SCHEMBL6504878 SCHEMBL6504878 0.41 1/20
SCHEMBL6500995 SCHEMBL6500995 0.40 1/20
SCHEMBL6504659 SCHEMBL6504659 0.40 1/20

Clinical trials — most relevant to CRH by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Acthar for Treatment of Proteinuria in Membranous Nephropathy Patients PHASE4COMPLETED
Prednisolone Versus Vigabatrin in the First-line Treatment of Infantile Spasms PHASE3WITHDRAWN
Novel Therapeutics in Posttraumatic Stress Disorder (PTSD): A Randomized Clinical Trial of Mifepristone PHASE2COMPLETED
Study of COLAL-PRED to Treat Moderate to Severe Ulcerative Colitis PHASE2COMPLETED
Vagal Nerve Stimulation for Intestinal Barrier Dysfunction in Healthy Volunteers PHASE1COMPLETED
Laboratory Studies on Oxytocin for Treatment of Alcohol Use Disorder PHASE1COMPLETED
Effects of Hormone Stimulation on Brain Scans for Cushing s Disease EARLY_PHASE1COMPLETED
Dose Response Relationship for Single Doses of Corticotropin Releasing Hormone (CRH) in Normal Volunteers and in Patients With Adrenal Insufficiency nanCOMPLETED
The Interplay Between Addiction to Tobacco Smoking and Sleep Quality Among Healthy Adults nanUNKNOWN
A Proof-of-concept Study Evaluating the Microbiota-gut-brain Axis nanRECRUITING
Corticotropin Releasing Hormone (CRH) Responsiveness in Children With Functional Dyspepsia nanWITHDRAWN
Feasibility of Breathwork Intervention With Older Adults After Knee Surgery nanNOT_YET_RECRUITING
The Effect of Minimal Flow Anesthesia on Oxidative and Neuroendocrine Stress Response nanACTIVE_NOT_RECRUITING
Identification of Physiological Sleep Indices That Reflect Clinical Improvement and Reduction in Stress Biomarkers After Stellate Ganglion Block in Patients With Posttraumatic Stress Disorder (PTSD) nanNOT_YET_RECRUITING
Salivary Cortisol as Stress Marker in Newborns Subjected to Double Weighing With Physiological Body Weight nanCOMPLETED
Massage Application and Motor Performance, Stress Assessment in Premature Babies nanUNKNOWN
Effects of Manual Therapy in Fibromyalgia Syndrome nanCOMPLETED
Measurement of Pituitary Volume and Hormonal Changes in Patients With Post-traumatic Stress Disorder nanCOMPLETED
Copeptin for Risk Stratification in Acute Stroke Patients: the CoRisk Study nanCOMPLETED
Effect of Breathing and Relaxation Exercises on Serum Cortisol Levels in Type 2 Diabetic Patients nanCOMPLETED
Adrenocorticotropic Hormone (ACTH) Stimulation and G Protein nanCOMPLETED
Effects of Corticotropin Releasing Hormone (CRH) on the Sleep in Patients With Hypopituitarism nanCOMPLETED
Molecular Pathways Involved in Knee Pain nanCOMPLETED
Brain Receptor Function in Post-Traumatic Stress Disorder nanCOMPLETED
Does Intravitreal Injection of Triamcinolone Acetonide Impairs the Adrenal Function nanCOMPLETED
DDAVP for Pituitary Adenoma nanRECRUITING
Examination of Brain Serotonin Receptors in Patients With Mood Disorders nanCOMPLETED
Rheumatoid Arthritis Adrenal Recovery Study nanCOMPLETED
Thyroid and Adrenal Disorders in ICU nanNOT_YET_RECRUITING
Stress, Hypothalamic-pituitary-adrenal (HPA) Dysfunction, and Relapse in Alcoholism nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a CRH binder may also engage these)

ProteinNameSimilarity
P49926 — 1.000 P49926 →
P06296 — 0.997 P06296 →
P01143 — 0.996 P01143 →
Q8CIT0 — 0.993 Q8CIT0 →
Q95MI6 — 0.993 Q95MI6 →
P01142 — 0.988 P01142 →
P55090 — 0.985 P55090 →
P49188 — 0.984 P49188 →
Q6Y4S4 — 0.982 Q6Y4S4 →
P81615 — 0.980 P81615 →
P55089 — 0.978 P55089 →
Q9QXV0 — 0.978 Q9QXV0 →
Q7TSB7 — 0.977 Q7TSB7 →
Q8CE23 — 0.977 Q8CE23 →
Q08535 — 0.976 Q08535 →
P83859 — 0.976 P83859 →
O77559 — 0.976 O77559 →
Q9UHG2 — 0.975 Q9UHG2 →
Q7TNK8 — 0.974 Q7TNK8 →
P61312 — 0.974 P61312 →
Q863C3 — 0.973 Q863C3 →
Q9QXU9 — 0.973 Q9QXU9 →
O93448 — 0.972 O93448 →
Q8N729 — 0.972 Q8N729 →
P63298 — 0.972 P63298 →
P13241 — 0.972 P13241 →
P47851 — 0.972 P47851 →
B0VXV8 — 0.972 B0VXV8 →
P63152 — 0.972 P63152 →
P25308 — 0.971 P25308 →