DDX42

ATP-dependent RNA helicase DDX42 · Q86XP3 · DDX42 on Sugi Atlas →

789 patent compounds predicted against DDX42, 747 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Riviciclib (SCHEMBL290347)	1.00	1/20
Riviciclib (SCHEMBL663219)	1.00	1/20
Riviciclib (SCHEMBL663220)	1.00	1/20
Riviciclib (SCHEMBL6119675)	1.00	1/20
Riviciclib (SCHEMBL290572)	0.98	1/20
Riviciclib (SCHEMBL291157)	0.98	1/20
Riviciclib (SCHEMBL665748)	0.98	1/20
Riviciclib (SCHEMBL665749)	0.98	1/20
Hydrochloric Acid (SCHEMBL2447940)	0.87	1/20
Hydrochloric Acid (SCHEMBL2447943)	0.87	1/20
Hydrochloric Acid (SCHEMBL2447947)	0.87	1/20
SCHEMBL2441179	0.85	1/20
SCHEMBL2441181	0.85	1/20
SCHEMBL2441187	0.85	1/20
Hydrochloric Acid (SCHEMBL3116099)	0.85	1/20
Hydrochloric Acid (SCHEMBL3116116)	0.85	1/20
Hydrochloric Acid (SCHEMBL3116948)	0.84	1/20
Hydrochloric Acid (SCHEMBL3116957)	0.84	1/20
Hydrochloric Acid (SCHEMBL3116967)	0.84	1/20
SCHEMBL1179589	0.84	1/20

Clinical trials — most relevant to DDX42 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Selinexor With ICE Chemotherapy in Secondary Central Nervous System Involving B-cell Non-Hodgkin Lymphoma	PHASE1/PHASE2	RECRUITING
Reverse Transcriptase Inhibitors in AGS	PHASE2	COMPLETED
Treatment of Refractory Diamond-Blackfan Anemia With Eltrombopag	PHASE1/PHASE2	COMPLETED
Study of Individuals and Families With Aberrations in DDX41 or Similar Cancer Predisposition Variants	nan	RECRUITING
DDX3X Syndrome -The Seaver Autism Center for Research and Treatment is Characterizing DDX3X-related Neurodevelopmental Disorders Using Genetic, Medical, and Neuropsychological Measures.	nan	COMPLETED
Better Delineation of DDX3X Related Phenotype and Epigenetic Signature.	nan	UNKNOWN
Cohort Evaluation of Body Fluids Early Detection of Cancer in High-risk Individuals	nan	RECRUITING
DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study	nan	RECRUITING
Shwachman Diamond Syndrome Registry and Study	nan	RECRUITING
Diamond Blackfan Anemia Registry (DBAR)	nan	RECRUITING
Clinical Genetics Branch Eligibility Screening Survey	nan	NOT_YET_RECRUITING
A Dose-escalation Trial of Stereotactic Ablative Body Radiotherapy for Non-spine Bone & Lymph Node Oligometastates	nan	COMPLETED
Cause of Familial Testicular Cancer	nan	COMPLETED
Studying Chromosomes in Samples From Younger Patients With Neuroblastoma	nan	COMPLETED
Whole-genome Sequencing Study in Patients With Diminished Ovarian Reserve	nan	UNKNOWN
Can Diabetes Distress be Reduced by Improving Entry to Care for Type 2 Diabetes Patients	nan	UNKNOWN
International PPB/DICER1 Registry	nan	RECRUITING
Exome Analysis in Hearing Impaired Patients	nan	UNKNOWN
Corpus Callosum Agenesis and Intellectual Disability	nan	COMPLETED
X-chromosome Inactivation, Epigenetics and the Transcriptome	nan	COMPLETED
Von Hippel-Lindau (VHL): Clinical Manifestations, Diagnosis, Management and Molecular Bases of Inherited Renal and Other Urologic Malignant Disorders	nan	RECRUITING
PCD New Gene Discovery	nan	COMPLETED
A Proof of Concept Study for the DNA Repair Driven by the Mesenchymal Stem Cells in Critical COVID-19 Patients	nan	COMPLETED
A Study Providing Genetic Testing to Find Those Who May Have Primary Ciliary Dyskinesia for Potential Clinical Trials	nan	ACTIVE_NOT_RECRUITING
Diagnosis and Phenotype Characterisation Using Genomics in Patients With Inherited Bone Marrow Failure (IBMDx Study)	nan	RECRUITING
Proseq Cancer: Genomic Profiling in Patients With Incurable Cancer in Search for Targeted Treatment	nan	RECRUITING
Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing	nan	RECRUITING
Collection of Serum and Tissue Samples From Patients With Biopsy-Proved or Suspected Malignant Disease	nan	RECRUITING
RDC Biomarker Study	nan	RECRUITING
Study of Neurodegenerative Diseases Induced Stem Cells in Patients and Healthy Family Controls.	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a DDX42 binder may also engage these)

Protein	Name	Similarity
Q5R7D1	—	1.000	Q5R7D1 →
Q5F485	—	1.000	Q5F485 →
Q810A7	—	0.997	Q810A7 →
Q7ZY47	—	0.995	Q7ZY47 →
A6RJA2	—	0.993	A6RJA2 →
A7ENE0	—	0.992	A7ENE0 →
P0CQ98	—	0.992	P0CQ98 →
Q9C813	—	0.992	Q9C813 →
Q9P7C7	—	0.992	Q9P7C7 →
Q2U2J6	—	0.991	Q2U2J6 →
A1CQA9	—	0.991	A1CQA9 →
A2QQA8	—	0.991	A2QQA8 →
A7A0P8	—	0.991	A7A0P8 →
Q6CEB8	—	0.990	Q6CEB8 →
P0CQ88	—	0.990	P0CQ88 →
Q61496	—	0.990	Q61496 →
P0CQ89	—	0.990	P0CQ89 →
Q4WT99	—	0.990	Q4WT99 →
A1D373	—	0.990	A1D373 →
O22907	—	0.990	O22907 →
Q4PFD9	—	0.990	Q4PFD9 →
A5DKW3	—	0.989	A5DKW3 →
Q75F95	—	0.989	Q75F95 →
A5E3K3	—	0.989	A5E3K3 →
P19109	—	0.989	P19109 →
P0CR07	—	0.989	P0CR07 →
Q1EB38	—	0.989	Q1EB38 →
O49289	—	0.989	O49289 →
Q5BDW4	—	0.989	Q5BDW4 →
A4QYM6	—	0.989	A4QYM6 →