GFRA1

GDNF family receptor alpha-1 · P56159 · GFRA1 on Sugi Atlas →

23 patent compounds predicted against GFRA1, 4 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1746652 SCHEMBL1746652 0.45 3/20
SCHEMBL1747049 SCHEMBL1747049 0.42 3/20
SCHEMBL16844693 SCHEMBL16844693 0.42 2/20
SCHEMBL1744666 SCHEMBL1744666 0.38 2/20

Clinical trials — most relevant to GFRA1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell. PHASE4UNKNOWN
Valproate and Levocarnitine in Children With Spinal Muscular Atrophy PHASE3UNKNOWN
Management of Retinitis Pigmentosa Via Combination of Wharton's Jelly-derived Mesenchymal Stem Cells and Magnovision PHASE3COMPLETED
Sunitinib for Advanced Thymus Cancer Following Earlier Treatment PHASE2COMPLETED
Intranasal Inhalations of M2 Macrophage Soluble Factors in Children With Developmental Speech Disorders PHASE1/PHASE2COMPLETED
Cilostazol in Parkinson's Disease PHASE2NOT_YET_RECRUITING
Phase Ib/II Study of Primary Chemotherapy With Paclitaxel, Gemcitabine, and Sunitinib PHASE1/PHASE2COMPLETED
Safety and Efficacy of the PAINLESS Nerve Growth Factor CHF6467 in Optic Pathway Glioma (OPG) PHASE2ACTIVE_NOT_RECRUITING
Intranasal Inhalations of Bioactive Factors Produced by M2 Macrophages in Patients With Organic Brain Syndrome PHASE1/PHASE2COMPLETED
GM604 Phase 2A Randomized Double-blind Placebo Controlled Pilot Trial in Amyotrophic Lateral Disease (ALS) PHASE2COMPLETED
GDNF in ideopathicParkinsons Disease PHASE2COMPLETED
Pharmacological Treatment of Rett Syndrome With Glatiramer Acetate (Copaxone) PHASE2COMPLETED
Study to Assess Safety and Efficacy of Fingolimod in Children With Rett Syndrome PHASE1/PHASE2COMPLETED
AAV2-GDNF for Advanced Parkinson s Disease PHASE1COMPLETED
GDNF Gene Therapy for Parkinson's Disease PHASE1ACTIVE_NOT_RECRUITING
Cryopreservation of Prepubertal Testicular Tissue for Preservation of Fertility in Young Boys With Cancer nanRECRUITING
Association of Urine BDNF and NGF With Lower Urinary System Parameters nanRECRUITING
Regulation of Stem Spermatogonia in the Mature Testis nanCOMPLETED
Effect of Vitamin D Administration Along With SSRIs in Patients With Major Depressive Disorder nanUNKNOWN
Changes in Skin Innervation of Neurologically Asymptomatic Type 2 Diabetic Patients: the Correlation With the Diabetic Parameters and Neurotrophins. nanUNKNOWN
A Retrospective Study to Determine the Incidence of NTRK Fusions. NTRK Study nanCOMPLETED
NTRK 1,2,3 Rearrangements in Patients With Solid Tumors nanACTIVE_NOT_RECRUITING
The Role of Epigenetic Modifications in Autism Spectrum Disorder nanUNKNOWN
Molecular Markers of Neuroplasticity During Exercise in People With Incomplete Spinal Cord Injury nanCOMPLETED
Cord Blood Serum in the Treatment of Neuro-Degenerative Ophthalmic Diseases. 1-Glaucoma nanCOMPLETED
Correlation Between LIF (Leukemia Inhibitory Factor ) Levels in Cord and Maternal Blood in Women Treated With Mg nanUNKNOWN
Effects of Subtenon-injected Autologous Platelet-rich Plasma on Visual Functions in Eyes With Retinitis Pigmentosa nanCOMPLETED
Association of Brain Derived Neurotrophic Factor (BDNF) rs6265 Gene Polymorphism With Susceptibility to Epilepsy nanUNKNOWN
Leukemia Inhibitory Factor Level in Intrauterine Growth Restriction Neonates nanUNKNOWN
Therapeutic Irrigation Procedures to Treat Apical Periodontitis nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a GFRA1 binder may also engage these)

ProteinNameSimilarity
P97785 1.000 P97785 →
Q62997 0.998 Q62997 →
O13156 0.997 O13156 →
Q5RAD6 0.995 Q5RAD6 →
GFRA2 GDNF family receptor alpha-2 0.993 landscape →
Q5E9X0 0.993 Q5E9X0 →
O08842 0.991 O08842 →
O13157 0.984 O13157 →
Q9QYM9 0.958 Q9QYM9 →
Q8IYR6 0.956 Q8IYR6 →
Q91590 0.955 Q91590 →
Q9UIK5 0.955 Q9UIK5 →
O95156 0.954 O95156 →
Q9QYV1 0.953 Q9QYV1 →
O93512 0.953 O93512 →
O13097 0.953 O13097 →
Q17QD6 0.952 Q17QD6 →
O95980 0.952 O95980 →
Q6PCX7 0.952 Q6PCX7 →
Q28145 0.951 Q28145 →
P52795 0.951 P52795 →
Q9Z0J1 0.950 Q9Z0J1 →
P52796 0.950 P52796 →
P01346 0.950 P01346 →
Q6PFE7 0.950 Q6PFE7 →
Q9H6X2 0.950 Q9H6X2 →
Q80UG6 0.949 Q80UG6 →
P09535 0.949 P09535 →
IGFBP4 Insulin-like growth factor-binding protein 4 0.949 landscape →
P83094 0.949 P83094 →