IGFBP4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL10923514	0.47	2/20
SCHEMBL29360098	0.47	2/20
SCHEMBL21979549	0.46	2/20
SCHEMBL30514356	0.46	2/20
SCHEMBL5825926	0.44	2/20
SCHEMBL29997546	0.44	2/20
SCHEMBL29752092	0.40	2/20
SCHEMBL22475758	0.35	2/20
SCHEMBL29857355	0.35	2/20
SCHEMBL6014808	1.00	1/20
SCHEMBL29930436	1.00	1/20
Water (SCHEMBL31319504)	0.97	1/20
SCHEMBL1758192	0.50	1/20
SCHEMBL9217699	0.46	1/20
SCHEMBL724972	0.45	1/20
SCHEMBL11374392	0.45	1/20
SCHEMBL21935558	0.45	1/20
Benzoic Acid (SCHEMBL27538220)	0.44	1/20
SCHEMBL8834235	0.44	1/20
SCHEMBL19003399	0.44	1/20

Clinical trials — most relevant to IGFBP4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Oral vs. Non-oral Contraceptives on the GH/IGF-1 Axis	PHASE4	COMPLETED
Efficacy of Oral Metformin vs Oral Doxycycline in Treating Acne Vulgaris	PHASE4	COMPLETED
Insulin-like Growth Factor (IGF-I) in Hemodialysis Patients	PHASE4	COMPLETED
Metformin Use to Reduce Disparities in Newly Diagnosed Breast Cancer	PHASE4	WITHDRAWN
Effect of Cytokines on Growth of Children With Chronic Kidney Failure	PHASE4	SUSPENDED
Study Assessing Potential Predictive Tumor Markers in Metastatic Colorectal Cancer	PHASE2	COMPLETED
Effect of Continuous GHRP-3 Infusion at on GH-IGF-I System, Blood Pressure, Glucose, and Insulin Resistance	PHASE1/PHASE2	WITHDRAWN
Effect of Functional Exercise in Patients With Spinal Bulbar Muscular Atrophy	PHASE1/PHASE2	COMPLETED
A Prevention Trial in Subjects at High Risk for Breast Cancer	PHASE2	COMPLETED
Defined Green Tea Catechins in Treating Patients With Prostate Cancer Undergoing Surgery to Remove the Prostate	PHASE1	COMPLETED
Estradiol-Receptor Blockade in Older Men and Women	PHASE1	COMPLETED
Prognostic Value of Protein IMP3 Expression in Cervical Cancer	nan	COMPLETED
Assessment of the Diagnostic Role of Serum Insulin-like Growth Factor Binding Protein-3 as a Potential Biomarker for Colorectal Cancer (CRC) in Egypt	nan	NOT_YET_RECRUITING
To Assess the Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in the UK	nan	COMPLETED
Metabolic and Inflammatory Responses to Hemodialysis and the Effect of a Meal	nan	COMPLETED
A Low-Insulinemic Dietary Intervention to Reduce Breast Cancer Risk in High-Risk Women	nan	COMPLETED
Lifestyles Of Health And Sustainability for Breast Cancer Survivors	nan	UNKNOWN
Effects of Standardized Meals on the Metabolic, Hormonal and Inflammatory Responses in Human	nan	COMPLETED
The Relationship Between Body Composition and Growth Hormone, SIRT Signaling, Protein Turnover and Insulin Sensitivity	nan	COMPLETED
Adipocytokines in Endometrial Cancer	nan	COMPLETED
Metabolic and Hormonal Effects of 5:2 Intermittent Fasting	nan	COMPLETED
Using IGF-1 for Nutritional Monitoring	nan	COMPLETED
Follow-up to Adult Height of a Cohort of Subjects Born Small for the Gestational Age and Treated With Growth Hormone	nan	COMPLETED
Biomarkers Related to Bone in Pediatric Gaucher Disease	nan	UNKNOWN
Study of Offspring of Women With Type 1 Diabetes	nan	COMPLETED
Effect of a Low-Calorie Diet and/or Exercise Program on Risk Factors for Developing Breast Cancer in Overweight or Obese Postmenopausal Women	nan	COMPLETED
Genetic Study of Insulin-Like Growth Factor-I Receptor Mutations in Patients With Intrauterine Growth Retardation	nan	UNKNOWN
Epidemiology of Insulin Growth Factor (IGF) and Cardiovascular Events	nan	COMPLETED
The Effect of Transcatheter VSD Closure on Children's Appetite, Hormones and Growth	nan	COMPLETED
Effect of Insulin Sensitization on IGF-1 Response to Growth Hormone in SGA Children	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a IGFBP4 binder may also engage these)

Protein	Name	Similarity
Q05716	—	1.000	Q05716 →
P47879	—	1.000	P47879 →
P21744	—	1.000	P21744 →
P24854	—	1.000	P24854 →
Q28893	—	0.997	Q28893 →
P20959	—	0.993	P20959 →
IGFBP3	Insulin-like growth factor-binding protein 3	0.985	landscape →
P47877	—	0.983	P47877 →
IGFBP5	Insulin-like growth factor-binding protein 5	0.982	landscape →
P47878	—	0.982	P47878 →
P49705	—	0.981	P49705 →
P12843	—	0.981	P12843 →
IGFBP2	Insulin-like growth factor-binding protein 2	0.981	landscape →
Q28985	—	0.980	Q28985 →
Q29400	—	0.979	Q29400 →
Q6Q484	—	0.978	Q6Q484 →
P16611	—	0.978	P16611 →
P24853	—	0.978	P24853 →
P24594	—	0.977	P24594 →
P21743	—	0.976	P21743 →
P24591	—	0.975	P24591 →
P47876	—	0.974	P47876 →
P15473	—	0.974	P15473 →
Q75ZP3	—	0.974	Q75ZP3 →
P13384	—	0.974	P13384 →
Q07079	—	0.973	Q07079 →
Q05717	—	0.973	Q05717 →
Q5XHC5	—	0.971	Q5XHC5 →
A4IIA2	—	0.970	A4IIA2 →
Q6PCX7	—	0.969	Q6PCX7 →