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Sugi Predict / Targets / GIGYF2

GIGYF2

GRB10-interacting GYF protein 2 · Q6Y7W6 · GIGYF2 on Sugi Atlas →

308 patent compounds predicted against GIGYF2, 200 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL15648215 SCHEMBL15648215 0.85 1/20
SCHEMBL15648297 SCHEMBL15648297 0.77 1/20
SCHEMBL13483496 SCHEMBL13483496 0.57 1/20
SCHEMBL18736358 SCHEMBL18736358 0.55 1/20
SCHEMBL18705311 SCHEMBL18705311 0.55 1/20
SCHEMBL18736247 SCHEMBL18736247 0.55 1/20
SCHEMBL18736528 SCHEMBL18736528 0.55 1/20
SCHEMBL18736481 SCHEMBL18736481 0.54 1/20
SCHEMBL19514692 SCHEMBL19514692 0.54 1/20
SCHEMBL19866392 SCHEMBL19866392 0.54 1/20
SCHEMBL1082044 SCHEMBL1082044 0.53 1/20
SCHEMBL4167487 SCHEMBL4167487 0.53 1/20
SCHEMBL12960753 SCHEMBL12960753 0.53 1/20
SCHEMBL18736482 SCHEMBL18736482 0.53 1/20
SCHEMBL24067567 SCHEMBL24067567 0.53 1/20
SCHEMBL3508582 SCHEMBL3508582 0.53 1/20
SCHEMBL13073624 SCHEMBL13073624 0.53 1/20
SCHEMBL18736372 SCHEMBL18736372 0.53 1/20
SCHEMBL20520128 SCHEMBL20520128 0.52 1/20
SCHEMBL23126132 SCHEMBL23126132 0.52 1/20

Clinical trials — most relevant to GIGYF2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus PHASE3UNKNOWN
TAP-GRIN: Interventional Study on Patients With GRIN-related Neurodevelopmental Disorders PHASE3RECRUITING
Deflazacort in Dysferlinopathies PHASE2/PHASE3COMPLETED
The Use of Inhaled Corticosteroids in the Treatment of Asthma is Children in the Emergency Room PHASE2/PHASE3COMPLETED
Intrathecal Administration of scAAV9/JeT-GAN for the Treatment of Giant Axonal Neuropathy PHASE1COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Characterization of Microbiological and Genetic Features in Prostate Cancer and Their Association with Disease Stage nanENROLLING_BY_INVITATION
Use of miRNAs in Growth Hormone Deficiency (GHD) nanUNKNOWN
Adrenocorticotropic Hormone (ACTH) Stimulation and G Protein nanCOMPLETED
Transcriptomic Profile of Patients Treated With Different Modalities of Spinal Cord Stimulation nanUNKNOWN
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus nanCOMPLETED
Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing nanCOMPLETED
Genetic Analysis of Gray Platelet Syndrome nanCOMPLETED
Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea nanRECRUITING
ADRB3, ROCK2 and GEF Levels in Overactive Bladder Patients nanCOMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA nanRECRUITING
Effect of Exercise on the Human Skeletal Muscle Phosphoproteome nanCOMPLETED
The Genetics of Cardiomyopathy and Heart Failure nanWITHDRAWN
Muscle Tissue Bank for Muscular Dystrophy nanCOMPLETED
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH) nanCOMPLETED
Decoding the Genetic Landscape of Skeletal Diseases nanRECRUITING
Implication of Long Non-coding RNA CCDC144NL-AS1/Micro RNA-143-3p Axis Expression Level as Novel Signature in Colorectal Cancer nanCOMPLETED
Role of Amino Acids and Genetic Disorder in Pathogenesis of Heart Failure nanUNKNOWN
Genetic Research of Monogenic Obesity in a Pediatric Cohort With Severe and Early Onset Obesity (GENOBE) nanUNKNOWN
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia nanUNKNOWN
Multidisciplinary Evaluation and a Genome-wide Analysis in a Cohort of Idiopathic Short Stature Patients nanRECRUITING
A Multicenter Phenotype-Genotype Analysis of LGMD Patients in China nanENROLLING_BY_INVITATION
Genetic Investigations in Children With Developmental and Epileptic Encephalopathies in Ho Chi Minh City, Vietnam nanUNKNOWN
Long-read Genome Sequencing for the Molecular Diagnosis of Dystonia nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a GIGYF2 binder may also engage these)

ProteinNameSimilarity
Q6Y7W8 — 1.000 Q6Y7W8 →
Q5U236 — 0.998 Q5U236 →
Q4KME6 — 0.995 Q4KME6 →
O75420 — 0.991 O75420 →
Q9Y2H5 — 0.989 Q9Y2H5 →
Q9WU62 — 0.989 Q9WU62 →
Q9JHU2 — 0.988 Q9JHU2 →
E7F5E1 — 0.988 E7F5E1 →
PRRC2C Protein PRRC2C 0.988 landscape →
NFRKB Nuclear factor related to kappa-B-binding protein 0.987 landscape →
Q99MR1 — 0.987 Q99MR1 →
P40645 — 0.987 P40645 →
Q0IHP2 — 0.987 Q0IHP2 →
Q8BG95 — 0.987 Q8BG95 →
O60237 — 0.987 O60237 →
Q32N92 — 0.987 Q32N92 →
P83038 — 0.987 P83038 →
Q9WVE9 — 0.987 Q9WVE9 →
Q14151 — 0.987 Q14151 →
P61406 — 0.987 P61406 →
F1M8W4 — 0.986 F1M8W4 →
Q9H1K0 — 0.986 Q9H1K0 →
Q5RCU4 — 0.986 Q5RCU4 →
Q9Z0R4 — 0.986 Q9Z0R4 →
P35711 — 0.986 P35711 →
Q58NQ4 — 0.986 Q58NQ4 →
P35710 — 0.986 P35710 →
Q2MJV9 — 0.986 Q2MJV9 →
Q7TPM1 — 0.986 Q7TPM1 →
Q4VYS1 — 0.986 Q4VYS1 →