Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1877560 | 0.80 | NR3C1 (0.61) | NR3C1GLUL | |
| SCHEMBL1872953 | 0.79 | NR3C1 (0.60) | NR3C1GLUL | |
| SCHEMBL1875023 | 0.79 | NR3C1 (0.77) | NR3C1GLUL | |
| SCHEMBL12956350 | 0.79 | NR3C1 (1.00) | NR3C1GLUL | |
| SCHEMBL1874785 | 0.78 | NR3C1 (0.62) | NR3C1GLUL | |
| SCHEMBL1874783 | 0.77 | NR3C1 (0.55) | NR3C1GLUL | |
| SCHEMBL12956409 | 0.77 | NR3C1 (0.93) | NR3C1GLUL | |
| SCHEMBL12956270 | 0.77 | NR3C1 (0.79) | NR3C1GLUL | |
| SCHEMBL12956552 | 0.75 | NR3C1 (0.79) | NR3C1GLUL | |
| SCHEMBL14091710 | 0.75 | NR3C1 (0.71) | NR3C1GLUL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110218225-A1 | NON-STEROIDAL LIGANDS FOR THE GLUCOCORTICOID RECEPTOR, COMPOSITIONS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-09-08 | — | — | US | disclosed |
| US-7947726-B2 | Non-steroidal ligands for the glucocorticoid receptor, and compositions thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-05-24 | — | — | US | disclosed |
| US-20090137655-A1 | Non-Steroidal Ligands for the Glucocorticoid Receptor, Compositions and Uses Thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-05-28 | — | — | US | disclosed |
| US-7485660-B2 | Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-02-03 | — | — | US | disclosed |
| US-20050054700-A1 | Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2005-03-10 | — | — | US | disclosed |
| US-6831093-B2 | For selectively modulating the activation, repression, agonism and antagonism effects of the glucocorticoid receptor in a patient; for therapy and prophylaxis of obesity, diabetes, depression, neurodegeneration or an inflammatory disease | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2004-12-14 | — | — | US | disclosed |
| US-20030176478-A1 | Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof | NIH-DEITR | 2003-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054700-A1 | Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof | NR3C1, NR3C2, GCGR | NR3C1 1/4885GLUL 2061/4885 |
| US-20110218225-A1 | NON-STEROIDAL LIGANDS FOR THE GLUCOCORTICOID RECEPTOR, COMPOSITIONS AND USES THEREOF | NR3C1, NR3C2, GCGR | NR3C1 1/4885GLUL 2061/4885 |
| US-20030176478-A1 | Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof | NR3C1, NR3C2, GCGR | NR3C1 1/4885GLUL 2061/4885 |
| US-20090137655-A1 | Non-Steroidal Ligands for the Glucocorticoid Receptor, Compositions and Uses Thereof | NR3C1, NR3C2, GCGR | NR3C1 1/4885GLUL 2061/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.