GNB1

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 · P62873 · GNB1 on Sugi Atlas →

5,761 patent compounds predicted against GNB1, 3,919 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL2777685 SCHEMBL2777685 1.00 11/20
SCHEMBL2778459 SCHEMBL2778459 1.00 10/20
SCHEMBL2790401 SCHEMBL2790401 1.00 10/20
SCHEMBL2789188 SCHEMBL2789188 0.82 10/20
SCHEMBL2779461 SCHEMBL2779461 0.67 10/20
SCHEMBL2779115 SCHEMBL2779115 0.66 10/20
SCHEMBL2789905 SCHEMBL2789905 0.65 10/20
SCHEMBL2779337 SCHEMBL2779337 1.00 9/20
SCHEMBL2846323 SCHEMBL2846323 1.00 9/20
SCHEMBL2846330 SCHEMBL2846330 1.00 9/20
SCHEMBL2848097 SCHEMBL2848097 0.80 9/20
SCHEMBL2782525 SCHEMBL2782525 0.70 9/20
SCHEMBL2777698 SCHEMBL2777698 0.69 9/20
SCHEMBL2848109 SCHEMBL2848109 0.65 9/20
SCHEMBL2840949 SCHEMBL2840949 0.64 8/20
SCHEMBL2777300 SCHEMBL2777300 1.00 7/20
Pyrogallol Red Pyrogallol Red (SCHEMBL3398009) 0.66 7/20
SCHEMBL2778161 SCHEMBL2778161 1.00 5/20
SCHEMBL2778373 SCHEMBL2778373 1.00 5/20
SCHEMBL2779595 SCHEMBL2779595 1.00 5/20

Clinical trials — most relevant to GNB1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell. PHASE4UNKNOWN
Safety and Efficacy of GS-100 Gene Therapy in Patients With NGLY1 Deficiency PHASE3ACTIVE_NOT_RECRUITING
A Multi-cohort Study of Safety, Efficacy, PK and PD of GNR-055 in Patients With Mucopolysaccharidosis Type II PHASE2/PHASE3RECRUITING
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus PHASE3UNKNOWN
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome PHASE3COMPLETED
Clinical Trial Assessing the GNbAC1 in Patients With Onset of Type 1 Diabetes Within 4 Years PHASE2COMPLETED
PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of McCune-Albright Syndrome PHASE1/PHASE2COMPLETED
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old PHASE2ACTIVE_NOT_RECRUITING
First-in-Human Study With GNbAC1 in Healthy Volunteers PHASE1COMPLETED
ADH1 and ADH2 Disease Monitoring Study (DMS) nanACTIVE_NOT_RECRUITING
GNAO1 Natural History Study nanUNKNOWN
A Natural History Study of Patients With GNE Myopathy and GNE-Related Diseases nanCOMPLETED
Adrenocorticotropic Hormone (ACTH) Stimulation and G Protein nanCOMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus nanUNKNOWN
Histamine Responsiveness in McCune-Albright Syndrome nanCOMPLETED
Biomarker for Sanfilippo Type A-B-C-D Disease (BioSanfilippo) nanWITHDRAWN
Long-read Genome Sequencing for the Molecular Diagnosis of Dystonia nanRECRUITING
GNE-Myopathy Disease Monitoring Program (GNEM-DMP): A Registry and Prospective Observational Natural History Study to Assess GNE Myopathy or Hereditary Inclusion Body Myopathy (HIBM) nanCOMPLETED
Study on the Carcinogenesis of Gα12 in Oral Cancer, and the Treatment of Oral Cancer Using Ga12 Inhibitor. nanUNKNOWN
Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing nanCOMPLETED
Quality of Life, Fatigue and Cognitive, Affective and Emotional Dysfunction in Patients With Cushing's Syndrome nanACTIVE_NOT_RECRUITING
Genomic Response Analysis of Heart Failure Therapy in African Americans nanCOMPLETED
Genetic Analysis of Gray Platelet Syndrome nanCOMPLETED
NGLY1 Natural History nanCOMPLETED
Evaluation of rhGH Replacement Therapy in Patients With Pseudohypoparathyroidism Type Ia (PHP Ia) nanUNKNOWN
Prospective Validation of a DNA Damage Repair-Hippo Pathway Signature in Patients With Advanced Gastric Cancer nanUNKNOWN
Inherited Reproductive Disorders nanRECRUITING
Multicenter Phenotype-Genotype Analysis of Vascular Stains to Optimize Treatment Utilizing Optical Coherence Tomography nanACTIVE_NOT_RECRUITING
Non Motor Symptoms in Glucocerebrosidase-related Parkinson's Disease nanENROLLING_BY_INVITATION
Genetic Investigations in Children With Developmental and Epileptic Encephalopathies in Ho Chi Minh City, Vietnam nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a GNB1 binder may also engage these)

ProteinNameSimilarity
P62872 1.000 P62872 →
Q5R5W8 1.000 Q5R5W8 →
P62874 1.000 P62874 →
P62871 1.000 P62871 →
Q6TMK6 1.000 Q6TMK6 →
Q61ZF6 1.000 Q61ZF6 →
P62879 1.000 P62879 →
P11017 1.000 P11017 →
P62880 1.000 P62880 →
P23232 1.000 P23232 →
O14435 1.000 O14435 →
P16520 1.000 P16520 →
P79959 1.000 P79959 →
P54313 1.000 P54313 →
Q6PH57 1.000 Q6PH57 →
Q08706 1.000 Q08706 →
Q9HAV0 1.000 Q9HAV0 →
P79147 1.000 P79147 →
O35353 1.000 O35353 →
O45040 1.000 O45040 →
Q5GIS3 1.000 Q5GIS3 →
P54311 0.999 P54311 →
P17343 0.999 P17343 →
Q61011 0.999 Q61011 →
P36408 0.998 P36408 →
P26308 0.998 P26308 →
P52287 0.997 P52287 →
P49178 0.995 P49178 →
P29387 0.994 P29387 →
Q6PNB6 0.994 Q6PNB6 →