Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNG2 | P59768 | 9/20 | 1.00 |
| ▸ | GNB1 | P62873 | 9/20 | 1.00 |
| ▸ | HPGD | P15428 | 6/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 6/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 1.00 |
| ▸ | HSPA1A | P0DMV8 | 4/20 | 1.00 |
| ▸ | HSPA8 | P11142 | 4/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 4/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 4/20 | 1.00 |
| ▸ | BRCA1 | P38398 | 3/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | GAPDH | P04406 | 1/20 | 1.00 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.56 |
| ▸ | CDC25A | P30304 | 1/20 | 0.56 |
| ▸ | CDC25B | P30305 | 1/20 | 0.56 |
| ▸ | STAT6 | P42226 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2846330 | 1.00 | GNG2 (1.00) | GNG2GNB1HPGDALOX15HSD17B10 | |
| SCHEMBL13771874 | 0.74 | HPGD (0.77) | GNG2GNB1HPGDALOX15HSD17B10 | |
| SCHEMBL13352283 | 0.72 | GNG2 (0.71) | GNG2GNB1HPGDALOX15HSD17B10 | |
| SCHEMBL29986877 | 0.72 | HPGD (1.00) | GNG2GNB1HPGDALOX15HSD17B10 | |
| SCHEMBL5080754 | 0.72 | HPGD (1.00) | GNG2GNB1HPGDALOX15HSD17B10 | |
| SCHEMBL2848109 | 0.71 | GNG2 (0.65) | GNG2GNB1HPGDALOX15HSD17B10 | |
| SCHEMBL7125963 | 0.71 | GNG2 (0.61) | GNG2GNB1HPGDALOX15HSD17B10 | |
| SCHEMBL2777300 | 0.70 | GNG2 (1.00) | GNG2GNB1HPGDALOX15HSD17B10 | |
| SCHEMBL16556417 | 0.69 | GNG2 (0.65) | GNG2GNB1HPGDALOX15HSD17B10 | |
| SCHEMBL2779115 | 0.68 | GNG2 (0.66) | GNG2GNB1HPGDALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080306031-A1 | Methods of Inhibiting Poxvirus Growth | SALK INSTITUTE FOR BIOLOGICAL STUDIES | 2008-12-11 | — | — | US | claimed |
| WO-2007047339-A2 | METHODS OF INHIBITING POXVIRUS GROWTH | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2007-04-26 | — | — | WO | claimed |
| US-8975259-B2 | Compositions and methods for inhibiting G protein signaling | UNIVERSITY OF ROCHESTER (US) | 2015-03-10 | — | — | US | disclosed |
| US-8975259-B2 | Compositions and methods for inhibiting G protein signaling | UNIVERSITY OF ROCHESTER (US) | 2015-03-10 | — | — | US | disclosed |
| US-8975259-B2 | Compositions and methods for inhibiting G protein signaling | UNIVERSITY OF ROCHESTER (US) | 2015-03-10 | — | — | US | disclosed |
| US-8748480-B2 | Methods for treating opioid tolerance | UNIVERSITY OF ROCHESTER (US) | 2014-06-10 | — | — | US | disclosed |
| US-8748480-B2 | Methods for treating opioid tolerance | UNIVERSITY OF ROCHESTER (US) | 2014-06-10 | — | — | US | disclosed |
| US-20130116313-A1 | Compositions and Methods for Inhibiting G Protein Signaling | UNIVERSITY OF ROCHESTER (US) | 2013-05-09 | — | — | US | disclosed |
| US-20130116313-A1 | Compositions and Methods for Inhibiting G Protein Signaling | UNIVERSITY OF ROCHESTER (US) | 2013-05-09 | — | — | US | disclosed |
| US-8076375-B2 | Methods of inhibiting poxvirus growth | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2011-12-13 | — | — | US | disclosed |
| US-20100130505-A1 | COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING | UNIVERSITY OF ROCHESTER (US) | 2010-05-27 | — | — | US | disclosed |
| US-20100130505-A1 | COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING | UNIVERSITY OF ROCHESTER (US) | 2010-05-27 | — | — | US | disclosed |
| US-20090221691-A1 | COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING | UNIVERSITY OF ROCHESTER (US) | 2009-09-03 | — | — | US | disclosed |
| US-20090221691-A1 | COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING | UNIVERSITY OF ROCHESTER (US) | 2009-09-03 | — | — | US | disclosed |
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2009-05-07 | — | — | US | disclosed |
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2009-05-07 | — | — | US | disclosed |
| WO-2009020677-A9 | COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING | UNIV ROCHESTER (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009020677-A2 | COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING | UNIVERSITY OF ROCHESTER (US) | 2009-02-12 | — | — | WO | disclosed |
| US-20080306031-A1 | Methods of Inhibiting Poxvirus Growth | SALK INSTITUTE FOR BIOLOGICAL STUDIES | 2008-12-11 | — | — | US | disclosed |
| WO-2007047339-A2 | METHODS OF INHIBITING POXVIRUS GROWTH | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2007-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | BCL2, BAX, BAD | GNG2 1544/4885GNB1 1702/4885HPGD 2147/4885 |
| US-20130116313-A1 | Compositions and Methods for Inhibiting G Protein Signaling | GNAI3, GNAI1, GNAI2 | GNG2 7/4885GNB1 4/4885HPGD 2898/4885 |
| US-20100130505-A1 | COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING | GNAI1, GNAI3, GNAI2 | GNG2 5/4885GNB1 4/4885HPGD 2169/4885 |
| US-20090221691-A1 | COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING | GNAI3, GNAI1, GNAI2 | GNG2 7/4885GNB1 4/4885HPGD 3003/4885 |
| US-20080306031-A1 | Methods of Inhibiting Poxvirus Growth | TTK, TXK, DCK | GNG2 1859/4885GNB1 1418/4885HPGD 2912/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.