Sugi Predict

Sugi Predict / Targets / GPS1

GPS1

COP9 signalosome complex subunit 1 · Q13098 · GPS1 on Sugi Atlas →

0 patent compounds predicted against GPS1, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to GPS1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome PHASE3COMPLETED
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus PHASE3UNKNOWN
Addition of Everolimus to Standard of Care in Carcinoma Gallbladder PHASE2/PHASE3RECRUITING
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
Reverse Transcriptase Inhibitors in AGS PHASE2COMPLETED
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old PHASE2ACTIVE_NOT_RECRUITING
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck PHASE1COMPLETED
Genetic Analysis of Gray Platelet Syndrome nanCOMPLETED
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia nanNOT_YET_RECRUITING
Inherited Reproductive Disorders nanRECRUITING
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus nanCOMPLETED
Inhibition of SENP1 for the Suppression of OS Growth and Metastasis nanUNKNOWN
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA nanRECRUITING
Study of Proteus Syndrome and Related Congenital Disorders nanRECRUITING
Transcriptomic Profile of Patients Treated With Different Modalities of Spinal Cord Stimulation nanUNKNOWN
Use of miRNAs in Growth Hormone Deficiency (GHD) nanUNKNOWN
Study of a Candidate Gene Involved in Goldenhar Syndrome. nanCOMPLETED
Implementation of Molecular Diagnostic Pathways nanUNKNOWN
SMYD3-Driven Metabolic Rewiring in Colorectal Liver Metastases nanNOT_YET_RECRUITING
Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders nanCOMPLETED
MEHMO Natural History and Biomarkers nanRECRUITING
Study of Metabolic Modifications in Children With Noonan Syndrome nanCOMPLETED
Long-read Genome Sequencing for the Molecular Diagnosis of Dystonia nanRECRUITING
Collection of Blood Samples for DNA in Motor Neuron Disease nanCOMPLETED
Tuberous Sclerosis Complex and Lymphangioleiomyomatosis Pregnancy Registry (TSC-LAM Registry) nanRECRUITING
Mesenchymal Stem Cells in NPM1 Mutated Low Risk Acute Myeloid Leukemia: a Study of the Tumor Microenvironment and Its Contribution to the Outcome nanCOMPLETED
Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing nanCOMPLETED
Genetic Investigations in Children With Developmental and Epileptic Encephalopathies in Ho Chi Minh City, Vietnam nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a GPS1 binder may also engage these)

ProteinNameSimilarity
Q6NRT5 — 0.999 Q6NRT5 →
Q99LD4 — 0.989 Q99LD4 →
P97834 — 0.987 P97834 →
Q3SZA0 — 0.971 Q3SZA0 →
Q5R648 — 0.971 Q5R648 →
O88544 — 0.971 O88544 →
Q641X8 — 0.970 Q641X8 →
Q5ZLA5 — 0.968 Q5ZLA5 →
COPS4 COP9 signalosome complex subunit 4 0.966 landscape →
Q4R5E6 — 0.966 Q4R5E6 →
A7Y521 — 0.966 A7Y521 →
CDC16 Cell division cycle protein 16 homolog 0.966 landscape →
Q4R6G8 — 0.966 Q4R6G8 →
Q5R8K9 — 0.966 Q5R8K9 →
P60229 — 0.966 P60229 →
Q3T0V3 — 0.966 Q3T0V3 →
EIF3E Eukaryotic translation initiation factor 3 subunit E 0.965 landscape →
Q68FS2 — 0.965 Q68FS2 →
Q3T102 — 0.965 Q3T102 →
Q8BG32 — 0.964 Q8BG32 →
Q2KJ46 — 0.964 Q2KJ46 →
Q9DBZ5 — 0.963 Q9DBZ5 →
Q8R349 — 0.963 Q8R349 →
Q3MHJ2 — 0.963 Q3MHJ2 →
F1LMZ8 — 0.962 F1LMZ8 →
Q2KI42 — 0.962 Q2KI42 →
PSMD11 26S proteasome non-ATPase regulatory subunit 11 0.962 landscape →
PSMD3 26S proteasome non-ATPase regulatory subunit 3 0.962 landscape →
AP2A2 AP-2 complex subunit alpha-2 0.962 landscape →
Q6P0H6 — 0.962 Q6P0H6 →