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GSPT2

Eukaryotic peptide chain release factor GTP-binding subunit ERF3B · Q8IYD1 · GSPT2 on Sugi Atlas →

821 patent compounds predicted against GSPT2, 577 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Motesanib Motesanib (SCHEMBL187470) 1.00 1/20
Motesanib Motesanib (SCHEMBL29354461) 1.00 1/20
Motesanib Motesanib (SCHEMBL445079) 0.98 1/20
Motesanib Motesanib (SCHEMBL446673) 0.95 1/20
Motesanib Motesanib (SCHEMBL29353301) 0.95 1/20
Motesanib Motesanib (SCHEMBL29361754) 0.95 1/20
SCHEMBL3150119 SCHEMBL3150119 0.85 1/20
SCHEMBL3144781 SCHEMBL3144781 0.81 1/20
SCHEMBL4537062 SCHEMBL4537062 0.81 1/20
SCHEMBL444347 SCHEMBL444347 0.79 1/20
SCHEMBL3155345 SCHEMBL3155345 0.79 1/20
SCHEMBL3159833 SCHEMBL3159833 0.79 1/20
SCHEMBL447085 SCHEMBL447085 0.78 1/20
SCHEMBL5626946 SCHEMBL5626946 0.78 1/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL448288) 0.78 1/20
SCHEMBL444745 SCHEMBL444745 0.76 1/20
SCHEMBL448334 SCHEMBL448334 0.75 1/20
SCHEMBL3884394 SCHEMBL3884394 0.75 1/20
SCHEMBL447875 SCHEMBL447875 0.73 1/20
SCHEMBL3151777 SCHEMBL3151777 0.71 1/20

Clinical trials — most relevant to GSPT2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Pharmacogenomic Evaluation of Antihypertensive Responses PHASE4COMPLETED
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus PHASE3UNKNOWN
Impact of Pantoprazole on 24-H Glycemic Control and on Post-prandial Glucose Excursion in Patients With Type 2 Diabetes PHASE3UNKNOWN
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome PHASE3COMPLETED
Efficacy of Alogliptin and Pioglitazone in Subjects With Type 2 Diabetes Mellitus PHASE3COMPLETED
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old PHASE2ACTIVE_NOT_RECRUITING
Simvastatin + Cetuximab/Irinotecan in K-ras Mutant Colorectal Cancer (CRC) PHASE2COMPLETED
A Pharmacodynamic Study of Leuprorelin Gelatin-Free Formulation in Female Subjects With Uterine Fibroids. PHASE2COMPLETED
NEO100 and High-Grade Meningioma PHASE2RECRUITING
Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans PHASE1COMPLETED
Follicle-Stimulating Hormone (FSH) and the Onset of Puberty EARLY_PHASE1COMPLETED
Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing nanCOMPLETED
Adrenocorticotropic Hormone (ACTH) Stimulation and G Protein nanCOMPLETED
Effects of an Amino Acid-Based hGH Secretagogue on Triiodythyronine nanCOMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus nanUNKNOWN
Evaluation of rhGH Replacement Therapy in Patients With Pseudohypoparathyroidism Type Ia (PHP Ia) nanUNKNOWN
Impact of Insulin Deprivation and Hyperglycemia on Plasma Protein Synthesis in People With Type 1 Diabetes Mellitus nanNOT_YET_RECRUITING
ADRB3, ROCK2 and GEF Levels in Overactive Bladder Patients nanCOMPLETED
Family Blood Pressure Program - GenNet Network nanCOMPLETED
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia nanRECRUITING
Genetic Variants Associated With Adolescent Suicide Attempts nanCOMPLETED
Investigation of Asprosin a Novel Adipokine in Periodontitis nanCOMPLETED
Consequence of Lifetime Isolated Growth Hormone Deficiency nanCOMPLETED
Inherited Reproductive Disorders nanRECRUITING
Gut Microbiome in Patients With Polycystic Ovary Syndrome nanUNKNOWN
Quality of Life, Fatigue and Cognitive, Affective and Emotional Dysfunction in Patients With Cushing's Syndrome nanACTIVE_NOT_RECRUITING
Thermogenic Silencer Regulatory Factors in Humans nanACTIVE_NOT_RECRUITING
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA nanRECRUITING
Genetic Characterization of Parkinson's Disease nanCOMPLETED
Relationship Between Genes Important in Blood Pressure Regulation and Blood Pressure Therapy in Hypertension nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a GSPT2 binder may also engage these)

ProteinNameSimilarity
Q5R4B3 — 1.000 Q5R4B3 →
Q8R050 — 1.000 Q8R050 →
Q149F3 — 0.998 Q149F3 →
Q2KHZ2 — 0.994 Q2KHZ2 →
Q69ZS7 — 0.994 Q69ZS7 →
Q6AXM7 — 0.994 Q6AXM7 →
HBS1L HBS1-like protein 0.991 landscape →
Q5R6Y0 — 0.990 Q5R6Y0 →
GSPT1 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A 0.987 landscape →
Q8C0D5 — 0.986 Q8C0D5 →
Q9HGI4 — 0.982 Q9HGI4 →
Q9SU24 — 0.982 Q9SU24 →
DHX29 ATP-dependent RNA helicase DHX29 0.981 landscape →
Q8VIJ5 — 0.981 Q8VIJ5 →
KDM5B Lysine-specific demethylase 5B 0.981 landscape →
O74718 — 0.981 O74718 →
B8JKF4 — 0.981 B8JKF4 →
Q9SP32 — 0.981 Q9SP32 →
Q9W074 — 0.981 Q9W074 →
Q7Z2Z2 — 0.981 Q7Z2Z2 →
OGA Protein O-GlcNAcase 0.981 landscape →
P57997 — 0.981 P57997 →
Q6KAI0 — 0.981 Q6KAI0 →
P46199 — 0.981 P46199 →
Q3UXZ9 — 0.981 Q3UXZ9 →
ASH2L Set1/Ash2 histone methyltransferase complex subunit ASH2 0.980 landscape →
Q5SMU7 — 0.980 Q5SMU7 →
O74774 — 0.980 O74774 →
KDM5D Lysine-specific demethylase 5D 0.980 landscape →
A0JMD0 — 0.980 A0JMD0 →