HAGH — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL21951992	1.00	1/20
SCHEMBL21964046	0.84	1/20
SCHEMBL21963935	0.81	1/20
SCHEMBL24176458	0.78	1/20
SCHEMBL21963930	0.75	1/20
SCHEMBL24176313	0.73	1/20
SCHEMBL21964112	0.72	1/20
SCHEMBL24176079	0.70	1/20
SCHEMBL21964146	0.69	1/20
SCHEMBL21951991	0.68	1/20
SCHEMBL21964058	0.67	1/20
SCHEMBL21964125	0.67	1/20
SCHEMBL24176460	0.67	1/20
SCHEMBL21964103	0.66	1/20
SCHEMBL21952076	0.65	1/20
SCHEMBL21963934	0.65	1/20
SCHEMBL21964145	0.62	1/20
SCHEMBL21964116	0.61	1/20
SCHEMBL21964102	0.61	1/20
SCHEMBL24176312	0.60	1/20

Clinical trials — most relevant to HAGH by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Thyroid Hormone for Treatment of Nonalcoholic Steatohepatitis in Veterans	PHASE2	RECRUITING
The Effects of Coenzyme A Combined With Abiraterone on Patients With CRPC	PHASE1/PHASE2	UNKNOWN
Acetylcarnitine and Insulin Sensitivity	PHASE2	COMPLETED
Overcoming Primary Resistance to Immunotherapy in Metastatic Melanoma	PHASE2	COMPLETED
Fatty Acid Oxidation Defects and Insulin Sensitivity	nan	COMPLETED
Diabetic Cardiomyopathy and Heart Failure	nan	WITHDRAWN
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Acute Infection in Mitochondrial Disease: Metabolism, Infection and Immunity	nan	RECRUITING
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders	nan	COMPLETED
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide	nan	RECRUITING
Study of Protein Translocation in Patients With Beta-Oxidation Disorders	nan	COMPLETED
The Effect of Green Coffee Extract on Blood Glucose Homeostasis in Healthy Adults	nan	COMPLETED
Effect of Exercise Training on Protein Expression in Skeletal Muscle Tissue After Exercise in Peripheral Arterial Disease	nan	COMPLETED
Compassionate Use of Triheptanoin (C7) for Inherited Disorders of Energy Metabolism	nan	NO_LONGER_AVAILABLE
The Natural History of Mitochondrial Diseases	nan	RECRUITING
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Mitochondria Inborn Errors of Metabolism and ANT Defects in Mitochondria Diseases	nan	COMPLETED
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia	nan	RECRUITING
Mitochondrial Remodeling After Exercise	nan	COMPLETED
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine	nan	COMPLETED
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders	nan	RECRUITING
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
Systemic Biomarkers of Brain Injury From Hyperammonemia	nan	RECRUITING
Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy	nan	RECRUITING
A Prospective Study of the Disease Characteristics of Adult Patients With Long Chain Fatty Acid Oxidation Disorders	nan	COMPLETED
Mitochondrial Dysfunction in Diabetes	nan	COMPLETED
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction	nan	COMPLETED
Mitochondrial Dysfunction in Phelan-McDermid Syndrome	nan	COMPLETED
Investigations Into ISCU Myopathy or Iron Sulfur Scaffold U Protein Myopathy	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a HAGH binder may also engage these)

Protein	Name	Similarity
Q4R6C1	—	1.000	Q4R6C1 →
Q3B7M2	—	1.000	Q3B7M2 →
Q5ZI23	—	0.998	Q5ZI23 →
B4F6K2	—	0.997	B4F6K2 →
Q28333	—	0.997	Q28333 →
Q99KB8	—	0.993	Q99KB8 →
O35952	—	0.993	O35952 →
Q6P963	—	0.993	Q6P963 →
Q8LDW8	—	0.990	Q8LDW8 →
Q26547	—	0.987	Q26547 →
Q9SID3	—	0.985	Q9SID3 →
Q5ZLY2	—	0.984	Q5ZLY2 →
Q9C8L4	—	0.981	Q9C8L4 →
A0A0F4YI33	—	0.981	A0A0F4YI33 →
Q3T094	—	0.980	Q3T094 →
O94250	—	0.980	O94250 →
Q8TB37	—	0.979	Q8TB37 →
O95571	—	0.978	O95571 →
E1ACR1	—	0.977	E1ACR1 →
Q7V6G8	—	0.977	Q7V6G8 →
O24496	—	0.977	O24496 →
Q95Q18	—	0.977	Q95Q18 →
M7TBG7	—	0.976	M7TBG7 →
Q4W945	—	0.976	Q4W945 →
Q5BH31	—	0.976	Q5BH31 →
P0CU68	—	0.976	P0CU68 →
Q5R6G3	—	0.976	Q5R6G3 →
Q8VEB6	—	0.976	Q8VEB6 →
Q3T0G5	—	0.976	Q3T0G5 →
A0A1L9WLF1	—	0.976	A0A1L9WLF1 →