HDHD5 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to HDHD5 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Cholic Acid for Hepatic Steatosis in Lipodystrophy	PHASE2	COMPLETED
Trial of the Histone-Deacetylase Inhibitor ITF2357 Followed by Mechlorethamine in Relapsed/Refractory Hodgkin's Lymphoma	PHASE1/PHASE2	COMPLETED
Pharmacogenetics of Disulfiram for Cocaine	PHASE2	COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides	PHASE1	COMPLETED
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish)	nan	UNKNOWN
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes	nan	RECRUITING
Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis.	nan	COMPLETED
Risk Burden of Lipoprotein Metabolic Gene Haplotypes	nan	COMPLETED
Identification of a New Gene Involved in Hereditary Lipodystrophy	nan	COMPLETED
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)	nan	RECRUITING
Evaluation of Phenotypic and Genetic Properties in Male Subjects Affected By Hypohidrotic Ectodermal Dysplasia	nan	COMPLETED
Genetic Analysis of Human Hypertensive End Stage Renal Disease (H-ESRD)	nan	COMPLETED
Targeting zDHHC Enzymes to Counteract Alzheimer's Disease	nan	NOT_YET_RECRUITING
SRT in Comparison to ERT on Immune Aspects and Bone Involvement in Gaucher Disease	nan	UNKNOWN
PCD New Gene Discovery	nan	COMPLETED
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients.	nan	COMPLETED
Cooperative Huntington's Observational Research Trial	nan	UNKNOWN
Hypophosphatemic Rickets in Norway	nan	UNKNOWN
Gene Expression in Obesity and Insulin Resistance	nan	COMPLETED
Genes Associated With Development of Pulmonary Arterial Hypertension in Patients With Congenital Shunt Lesions	nan	RECRUITING
Target of Suv420h1/2 in Hepatocytes	nan	RECRUITING
Screening of Lysosomal Storage Disorders Diseases in Minority Groups	nan	UNKNOWN
Elucidating the Molecular and Biochemical Basis of the Human AhR-mutation Disease	nan	UNKNOWN
Replacement of Vitamin D in Patients With Active Tuberculosis	nan	COMPLETED
A Proof of Concept Study for the DNA Repair Driven by the Mesenchymal Stem Cells in Critical COVID-19 Patients	nan	COMPLETED
High-Density Lipoprotein (HDL) Treatment Study	nan	COMPLETED
Gene Modifiers of Cystic Fibrosis Lung Disease	nan	ACTIVE_NOT_RECRUITING
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity.	nan	COMPLETED
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease	nan	RECRUITING
Pilot Study on Caffeine Efficiency in ADCY5-related Dyskinesia	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a HDHD5 binder may also engage these)

Protein	Name	Similarity
Q91WM2	—	0.994	Q91WM2 →
Q148G5	—	0.973	Q148G5 →
O43272	—	0.969	O43272 →
Q9JLV6	—	0.969	Q9JLV6 →
F1QWK4	—	0.965	F1QWK4 →
Q9WU79	—	0.965	Q9WU79 →
Q8IVS8	—	0.964	Q8IVS8 →
HDAC10	Polyamine deacetylase HDAC10	0.963	landscape →
Q8BZG5	—	0.962	Q8BZG5 →
Q14CH1	—	0.962	Q14CH1 →
PNKP	Bifunctional polynucleotide phosphatase/kinase	0.961	landscape →
LPCAT1	Lysophosphatidylcholine acyltransferase 1	0.961	landscape →
MAP4K2	Mitogen-activated protein kinase kinase kinase kinase 2	0.961	landscape →
Q5I0L3	—	0.961	Q5I0L3 →
Q921Q3	—	0.961	Q921Q3 →
D3ZDK7	—	0.960	D3ZDK7 →
Q8BYL4	—	0.960	Q8BYL4 →
BCAT2	Branched-chain-amino-acid aminotransferase, mitochondrial	0.960	landscape →
Q9UF12	—	0.959	Q9UF12 →
Q6XQN1	—	0.959	Q6XQN1 →
TRPM4	Transient receptor potential cation channel subfamily M member 4	0.959	landscape →
Q8QZY2	—	0.959	Q8QZY2 →
Q6P3E7	—	0.959	Q6P3E7 →
Q9QZC8	—	0.959	Q9QZC8 →
Q8VCZ9	—	0.959	Q8VCZ9 →
Q63186	—	0.959	Q63186 →
Q8ND23	—	0.958	Q8ND23 →
Q8BML1	—	0.958	Q8BML1 →
Q86TX2	—	0.958	Q86TX2 →
Q7TSA0	—	0.958	Q7TSA0 →