IL1B — 21 ClinVar variants

All ClinVar germline IL1B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 14 flagged for review →

2 Benign · 1 Benign/Likely benign · 4 Likely benign · 14 Uncertain significance

Full IL1B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 14

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 12

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 2

The independent predictors disagree with each other — read with care.

All IL1B variants

Benign 2

c.100-10C>T Multiple submitters
p.Gly46= Multiple submitters

Benign/Likely benign 1

p.Tyr57= Multiple submitters

Likely benign 4

p.Ile103= Single submitter
p.Lys210= Single submitter
p.Tyr140Cys Single submitter
c.100-5C>T No assertion criteria IL1B-related disorder

Uncertain significance 14

p.Asn223Ser Single submitter ⚠
p.Asn235Ser Single submitter ⚠
p.Asp38Glu Single submitter ⚠
p.Asp54Asn Single submitter ⚠
p.Asp72Asn Single submitter ⚠
p.Gln31Arg Single submitter ⚠
p.Gln49Lys Single submitter ⚠
p.Glu101Asp Single submitter ⚠
p.Glu141Asp Single submitter ⚠
p.Leu122Val Single submitter ⚠
p.Pro80Ser Single submitter ⚠
p.Tyr15His Single submitter ⚠
p.Val188Met Single submitter ⚠
p.Glu10Lys No assertion criteria ⚠