JUP

Junction plakoglobin · P14923 · JUP on Sugi Atlas →

0 patent compounds predicted against JUP, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to JUP by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy PHASE2RECRUITING
Phase 2 Study Evaluating the Efficacy of the Combination of DKN-01 (DKK1 Inhibitor, Leap Therapeutics) and Pembrolizumab in the Treatment of Advanced or Recurrent Endometrial Cancer PHASE2ACTIVE_NOT_RECRUITING
A Study to Evaluate the Safety and Efficacy of Vactosertib and Imatinib in Patients With Advanced Desmoid Tumor PHASE1/PHASE2COMPLETED
Gene Therapy for ACM Due to a PKP2 Pathogenic Variant PHASE1/PHASE2ACTIVE_NOT_RECRUITING
Pharmacogenomically Selected Treatment for Gastric and Gastroesophageal Junction (GEJ) Tumors PHASE2COMPLETED
68Ga-PMD22 PET/CT Examination Targeting CLDN18.2 EARLY_PHASE1UNKNOWN
Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy nanCOMPLETED
Predictive Value of E-cadherin, β-catenin and SOX4 in Recurrence and/or Progression of Non-muscle Invasive Urinary Bladder Transitional Cell Carcinoma. A Retrospective Study nanCOMPLETED
PKP2-ACM Natural History Study nanRECRUITING
Mayo AVC Registry and Biobank nanRECRUITING
Profiling Gingival Crevicular Fluid β-Catenin Level With 8-OHdG and Total Antioxidants Capacity During Healing of Periodontal Pockets: A 3-month Clinical Trial nanNOT_YET_RECRUITING
Multidisciplinary Study of Right Ventricular Dysplasia nanCOMPLETED
Epithelial Mesenchymal Transition and Periodontitis nanUNKNOWN
DNA Analysis From Isolated Cardiomyocytes in the Molecular Diagnosis of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia nanCOMPLETED
CTNNB1 Neurodevelopmental Syndrome - Natural History Study nanRECRUITING
Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) nanRECRUITING
Clinical Studies on Bile Acids in Barrett's Esophagus nanCOMPLETED
FAPI PET/CT Imaging in Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) (FAPI-ARVC)) nanRECRUITING
A Prospective Study Into the Risk of Colorectal Neoplasms in Individuals With a Family History of Advanced Adenomas (Sibling AN Study) nanUNKNOWN
Effect of Non-Surgical Periodontal Therapy on Salivary Biomarkers in Smokers and Non-Smokers With Periodontitis nanRECRUITING
PET/CT Scans Using the Tracer 11C-Csar, a Bile Acid Analog, to Depict and Visualize Cholestatic Disorders in Patients with Genetic Liver Disorders and Healthy Individuals nanENROLLING_BY_INVITATION
Artificial Intelligence for the Prioritization of Genetic Background in Brugada Syndrome nanCOMPLETED
Confocal Laser Endomicroscopy Findings in Patients With Proctosigmoiditis Before and After Initiation of Treatment nanCOMPLETED
Clinical and Molecular Characterization of Familial Microsatellite Stable Colorectal Cancer nanUNKNOWN
Focal Radiotherapy Plus Low Dose Craniospinal Irradiation Followed by Adjuvant Chemotherapy in WNT Medulloblastoma. nanRECRUITING
Molecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases nanUNKNOWN
Genetic Clues to Chordoma Etiology: A Protocol to Identify Sporadic Chordoma Patients for Studies of Cancer-Susceptibility Genes nanACTIVE_NOT_RECRUITING
Signs and Symptoms Associated With Molecular Defects in Genetically Inherited Heart Disease nanCOMPLETED
Studying the Role of Circulating Tumor Cell Clusters in Patients With High-risk Early Breast Cancer, Study GALIA nanRECRUITING
Cohort Evaluation of Body Fluids Early Detection of Cancer in High-risk Individuals nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a JUP binder may also engage these)

ProteinNameSimilarity
Q8WNW3 1.000 Q8WNW3 →
Q6P0K8 1.000 Q6P0K8 →
Q02257 1.000 Q02257 →
Q8SPJ1 1.000 Q8SPJ1 →
Q9PVF7 1.000 Q9PVF7 →
P30998 0.996 P30998 →
Q17GS9 0.993 Q17GS9 →
P18824 0.992 P18824 →
P35223 0.991 P35223 →
Q29I35 0.988 Q29I35 →
Q02453 0.987 Q02453 →
Q7QHW5 0.985 Q7QHW5 →
P35224 0.984 P35224 →
Q26626 0.969 Q26626 →
CTNND1 Catenin delta-1 0.969 landscape →
Q05AL1 0.967 Q05AL1 →
P30999 0.967 P30999 →
Q68FK4 0.965 Q68FK4 →
MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 0.964 landscape →
Q8BPM2 0.963 Q8BPM2 →
Q5R6S3 0.962 Q5R6S3 →
Q9UQB3 0.961 Q9UQB3 →
Q6EDY6 0.960 Q6EDY6 →
KPNA2 Importin subunit alpha-1 0.960 landscape →
Q9DBR3 0.960 Q9DBR3 →
P42346 0.959 P42346 →
MTOR Serine/threonine-protein kinase mTOR 0.959 landscape →
Q6C5Y8 0.959 Q6C5Y8 →
Q9JLN9 0.959 Q9JLN9 →
ATP6V1H V-type proton ATPase subunit H 0.959 landscape →