KPNA2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL5468199	1.00	1/20
SCHEMBL14235363	0.85	1/20
SCHEMBL14125564	0.82	1/20
SCHEMBL29576538	0.82	1/20
SCHEMBL31253845	0.78	1/20
SCHEMBL14235633	0.76	1/20
SCHEMBL14235923	0.76	1/20
SCHEMBL14907727	0.76	1/20
SCHEMBL14235362	0.75	1/20
SCHEMBL14235926	0.75	1/20
SCHEMBL14235624	0.74	1/20
SCHEMBL14235632	0.74	1/20
SCHEMBL14235357	0.74	1/20
SCHEMBL5462701	0.72	1/20
SCHEMBL14235627	0.72	1/20
SCHEMBL14235246	0.70	1/20
SCHEMBL5470128	0.69	1/20
SCHEMBL14235369	0.69	1/20
SCHEMBL2551153	0.68	1/20
SCHEMBL16139270	0.67	1/20

Clinical trials — most relevant to KPNA2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Hydroxychloroquine and Ivermectin for the Treatment of COVID-19 Infection	PHASE3	COMPLETED
A Study of KRN23 in Pediatric Patients With X-linked Hypophosphatemic Rickets/Osteomalacia	PHASE3	COMPLETED
Efficacy of Ivermectin in COVID-19	PHASE1/PHASE2	COMPLETED
Selinexor With ICE Chemotherapy in Secondary Central Nervous System Involving B-cell Non-Hodgkin Lymphoma	PHASE1/PHASE2	RECRUITING
Phase II Trial of Lonafarnib (a Farnesyltransferase Inhibitor) for Progeria	PHASE2	COMPLETED
Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes	PHASE2	UNKNOWN
A Clinical Study on the Efficacy and Safety of Methotrexate (MTX) or Thiotepa (for MTX Intolerance) or Temozolomide (TMZ) Combined With Orelabrutinib and Selinexor in Relapsed/Refractory Primary or Secondary Central Nervous System Lymphoma（SELINA）	nan	RECRUITING
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients	nan	RECRUITING
Mechanisms of Resistance to Amivantamab in Patients With NSCLC With EGFR Exon 20 Insertion	nan	RECRUITING
Quantitative Assessment of the Etiologies of Megalencephaly Associated With a Detectable Tumor Risk	nan	NOT_YET_RECRUITING
A Study on the Prevalence of Mutation of Cerebrotendinous Xanthomatosis (CTX)	nan	UNKNOWN
Finding Genes With NGS Techniques in Whom Mutations Cause Neurological Diseases	nan	UNKNOWN
Steroid Treatment of Idiopathic Nephrotic Syndrome	nan	COMPLETED
Phenotype/Genotype Correlations in Neuromuscular Disorders	nan	COMPLETED
Genetic Investigations in Children With Developmental and Epileptic Encephalopathies in Ho Chi Minh City, Vietnam	nan	UNKNOWN
Induced Pluripotent Stem Cells for Niemann Pick Disease	nan	COMPLETED
Comparative 2-D Tumor Analysis in Familial Gliomas	nan	COMPLETED
Chordoma Family Study	nan	COMPLETED
Whole Exome Sequencing in Prenatal Diagnosis of Agenesis of the Corpus Callosum	nan	COMPLETED
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING
Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders	nan	RECRUITING
Precision Genomics Medicine Biobank	nan	RECRUITING
Biomarker for Niemann Pick Type C Disease (BioNPC)	nan	WITHDRAWN
Pulmonary Hypertension--Mechanisms and Family Registry	nan	COMPLETED
Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders	nan	COMPLETED
Hydroxychloroquin (HCQ) in chILD of Genetic Defect	nan	COMPLETED
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives	nan	UNKNOWN
LINC00511/miR-185-3p Axis and miR-301a-3p Markers for Breast Cancer Diagnosis	nan	COMPLETED
Molecular Mechanism of Nasopharyngeal Carcinoma	nan	UNKNOWN
Genetics of Neonatal Encephalopathy and Related Disorders	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a KPNA2 binder may also engage these)

Protein	Name	Similarity
P52293	—	1.000	P52293 →
O80480	—	0.998	O80480 →
Q9SLX0	—	0.998	Q9SLX0 →
F4JL11	—	0.998	F4JL11 →
Q71VM4	—	0.995	Q71VM4 →
Q96321	—	0.994	Q96321 →
Q9FWY7	—	0.993	Q9FWY7 →
P52171	—	0.993	P52171 →
P52170	—	0.992	P52170 →
O04294	—	0.991	O04294 →
O22478	—	0.990	O22478 →
B6HJ92	—	0.988	B6HJ92 →
G5EB89	—	0.987	G5EB89 →
O35344	—	0.985	O35344 →
KPNA3	Importin subunit alpha-4	0.984	landscape →
O14063	—	0.982	O14063 →
KPNA4	Importin subunit alpha-3	0.982	landscape →
P52295	—	0.981	P52295 →
O94374	—	0.979	O94374 →
O35343	—	0.979	O35343 →
Q76P29	—	0.977	Q76P29 →
Q02821	—	0.976	Q02821 →
A9QM74	—	0.976	A9QM74 →
C6K7I2	—	0.975	C6K7I2 →
O18388	—	0.973	O18388 →
Q29G21	—	0.971	Q29G21 →
Q9FJ09	—	0.970	Q9FJ09 →
P45437	—	0.969	P45437 →
C1JZ66	—	0.969	C1JZ66 →
Q8W207	—	0.967	Q8W207 →