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KCNJ3

G protein-activated inward rectifier potassium channel 1 · P48549 · KCNJ3 on Sugi Atlas →

18,308 patent compounds predicted against KCNJ3, 9,124 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1239446 SCHEMBL1239446 0.72 20/20
SCHEMBL1237053 SCHEMBL1237053 0.56 20/20
SCHEMBL1238635 SCHEMBL1238635 0.56 20/20
SCHEMBL1240105 SCHEMBL1240105 0.56 20/20
SCHEMBL1239310 SCHEMBL1239310 0.54 20/20
SCHEMBL1239394 SCHEMBL1239394 0.51 20/20
SCHEMBL1239786 SCHEMBL1239786 0.51 20/20
SCHEMBL1237257 SCHEMBL1237257 0.51 20/20
SCHEMBL1238555 SCHEMBL1238555 0.51 20/20
SCHEMBL1238341 SCHEMBL1238341 0.59 19/20
SCHEMBL1239289 SCHEMBL1239289 0.66 18/20
SCHEMBL1238084 SCHEMBL1238084 0.66 18/20
SCHEMBL1010934 SCHEMBL1010934 0.63 18/20
SCHEMBL1239098 SCHEMBL1239098 0.63 18/20
SCHEMBL1013226 SCHEMBL1013226 0.61 18/20
SCHEMBL1238133 SCHEMBL1238133 0.61 18/20
SCHEMBL1239151 SCHEMBL1239151 0.60 18/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL1238595) 0.51 18/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL1236611) 0.49 18/20
SCHEMBL1238206 SCHEMBL1238206 0.82 17/20

Clinical trials — most relevant to KCNJ3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Long-Term Sulfonylurea Response in KCNJ11 Neonatal Diabetes PHASE4COMPLETED
Long-Term Sulfonylurea Response in ABCC8 Neonatal Diabetes (SuResponsSUR) PHASE4UNKNOWN
Effect of Methadone and Hydromorphone on the QT Interval After Anesthesia and Surgery PHASE4RECRUITING
Sulphonylurea Receptor Mutation and Responsiveness to Gliclazide - a Pilot Proof of Concept, Randomised Cross-over Study PHASE4COMPLETED
Glibentek in Patients With Neonatal Diabetes Secondary to Mutations in K+-ATP Channels PHASE3COMPLETED
Effect of Amiodarone on the Procedure Outcome in Long-standing Persistent Atrial Fibrillation Undergoing Pulmonary Vein Antral Isolation PHASE3COMPLETED
Mutation-specific Therapy for the Long QT Syndrome PHASE2COMPLETED
Long-term Efficacy Study of Sodium Channel Blocker in LQT3 Patients PHASE2COMPLETED
Efficacy and Safety of AUT00063 Versus Placebo in Age-Related Hearing Loss PHASE2COMPLETED
Evaluating Possible Improvement in Tinnitus Severity After 28 Days Dosing of the Study Drug AUT00063 Compared to Placebo PHASE2COMPLETED
Safety, Blood Levels and Effects of AUT00201 in Patients With MEAK PHASE1COMPLETED
Preoperative Imatinib and Fampridine in KIT Mutant Gastrointestinal Stromal Tumor PHASE1RECRUITING
The Physiological Effects of Human Ether-a-go-go-Related Gene (hERG)Blockade on Metabolism nanCOMPLETED
Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA) nanUNKNOWN
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients. nanUNKNOWN
Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome nanRECRUITING
Targeting Potassium Channels to Reprogram Glioblastoma Microenvironment: in Vitro and in Vivo Studies nanUNKNOWN
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives nanUNKNOWN
A Positional Cloning Study on Schizophrenia nanCOMPLETED
Characteristics of Andersen-Tawil Syndrome nanCOMPLETED
Genetic Determinants of Sudden Cardiac Death nanCOMPLETED
Role of Nitric Oxide in Diabetic Patients With Erectile Dysfunction nanCOMPLETED
A Cohort Study on the Prognosis of Neonatal KCNQ2 Gene-associated Epileptic Encephalopathy nanUNKNOWN
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain. nanUNKNOWN
Role of KATP Channel Loss in Type 2 Diabetes nanRECRUITING
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services nanUNKNOWN
The Effects of the Anesthetic Drug Propofol on the Way the Heart Recovers Between Beats nanCOMPLETED
Qatar Cardiovascular Biorepository of AF Patients nanUNKNOWN
Factors Affecting Salt Intake in Young Adults nanUNKNOWN
The Effects of the Anti Nausea Drugs Droperidol and Ondansetron on the Way the Heart Recovers Between Beats nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a KCNJ3 binder may also engage these)

ProteinNameSimilarity
P63251 — 1.000 P63251 →
P63250 — 1.000 P63250 →
Q90854 — 1.000 Q90854 →
E1BNE9 — 1.000 E1BNE9 →
P49658 — 0.993 P49658 →
P35561 — 0.993 P35561 →
O19182 — 0.992 O19182 →
P52190 — 0.992 P52190 →
P52185 — 0.992 P52185 →
KCNJ2 Inward rectifier potassium channel 2 0.992 landscape →
P48542 — 0.992 P48542 →
P49656 — 0.991 P49656 →
P52189 — 0.991 P52189 →
Q64273 — 0.991 Q64273 →
F1NHE9 — 0.991 F1NHE9 →
Q9NPI9 — 0.990 Q9NPI9 →
O18839 — 0.990 O18839 →
Q64198 — 0.989 Q64198 →
Q4TZY1 — 0.989 Q4TZY1 →
P48550 — 0.988 P48550 →
Q5NVJ6 — 0.988 Q5NVJ6 →
B7U540 — 0.988 B7U540 →
Q14500 — 0.987 Q14500 →
P52187 — 0.987 P52187 →
P63253 — 0.987 P63253 →
P52186 — 0.987 P52186 →
P52188 — 0.987 P52188 →
KCNJ4 Inward rectifier potassium channel 4 0.987 landscape →
Q9MYY9 — 0.987 Q9MYY9 →
Q9Z307 — 0.987 Q9Z307 →