KCNJ4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL11592761	0.58	1/20
SCHEMBL2497999	0.57	1/20
Hydrochloric Acid (SCHEMBL11591681)	0.57	1/20
SCHEMBL607881	0.55	1/20
SCHEMBL2475199	0.55	1/20
SCHEMBL2494040	0.54	1/20
SCHEMBL29930181	0.54	1/20
SCHEMBL1170484	0.54	1/20
SCHEMBL2495066	0.54	1/20
SCHEMBL21936197	0.52	1/20
SCHEMBL2505043	0.50	1/20
SCHEMBL5499044	0.50	1/20
SCHEMBL24760067	0.50	1/20
SCHEMBL5479116	0.48	1/20
SCHEMBL5479122	0.48	1/20
SCHEMBL13332623	0.48	1/20
SCHEMBL607337	0.47	1/20
SCHEMBL496166	0.47	1/20
SCHEMBL19645372	0.47	1/20
SCHEMBL2475227	0.47	1/20

Clinical trials — most relevant to KCNJ4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Long-Term Sulfonylurea Response in ABCC8 Neonatal Diabetes (SuResponsSUR)	PHASE4	UNKNOWN
Effect of Methadone and Hydromorphone on the QT Interval After Anesthesia and Surgery	PHASE4	RECRUITING
Switching From Insulin to Sulfonylurea in Diabetes Associated With Variants in MODY Genes	PHASE4	UNKNOWN
Effect of Amiodarone on the Procedure Outcome in Long-standing Persistent Atrial Fibrillation Undergoing Pulmonary Vein Antral Isolation	PHASE3	COMPLETED
Mutation-specific Therapy for the Long QT Syndrome	PHASE2	COMPLETED
Long-term Efficacy Study of Sodium Channel Blocker in LQT3 Patients	PHASE2	COMPLETED
A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy	PHASE1/PHASE2	RECRUITING
Sandostatine® LP and Hyperinsulinism	PHASE2	COMPLETED
Safety, Blood Levels and Effects of AUT00201 in Patients With MEAK	PHASE1	COMPLETED
Safety, Tolerability and Pharmacokinetics of NTP42:KVA4	PHASE1	COMPLETED
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients.	nan	UNKNOWN
Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA)	nan	UNKNOWN
The Physiological Effects of Human Ether-a-go-go-Related Gene (hERG)Blockade on Metabolism	nan	COMPLETED
Characteristics of Andersen-Tawil Syndrome	nan	COMPLETED
Qatar Cardiovascular Biorepository of AF Patients	nan	UNKNOWN
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives	nan	UNKNOWN
Genetic Determinants of Sudden Cardiac Death	nan	COMPLETED
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain.	nan	UNKNOWN
Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome	nan	RECRUITING
A Cohort Study on the Prognosis of Neonatal KCNQ2 Gene-associated Epileptic Encephalopathy	nan	UNKNOWN
The Effects of the Anti Nausea Drugs Droperidol and Ondansetron on the Way the Heart Recovers Between Beats	nan	COMPLETED
The Effects of the Anesthetic Drug Propofol on the Way the Heart Recovers Between Beats	nan	COMPLETED
Impact on Risk Stratification of Overlap Syndrome Phenotype in Patients With E1784K Mutation in SCN5A	nan	COMPLETED
A Positional Cloning Study on Schizophrenia	nan	COMPLETED
Interaction of Potassium and Genetic Risk Variants on Diabetes Risk	nan	COMPLETED
The Natural History of TRPV4 Neuropathy	nan	RECRUITING
Metabolism of Patients With Genetically Caused Cardiac Arrhythmia	nan	UNKNOWN
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services	nan	UNKNOWN
Role of Nitric Oxide in Diabetic Patients With Erectile Dysfunction	nan	COMPLETED
Feasibility of Improving Risk Stratification in Brugada Syndrome	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a KCNJ4 binder may also engage these)

Protein	Name	Similarity
Q64198	—	1.000	Q64198 →
P52190	—	1.000	P52190 →
P52189	—	1.000	P52189 →
Q4TZY1	—	0.994	Q4TZY1 →
B7U540	—	0.992	B7U540 →
Q14500	—	0.991	Q14500 →
P52187	—	0.991	P52187 →
P52188	—	0.990	P52188 →
KCNJ3	G protein-activated inward rectifier potassium channel 1	0.990	landscape →
P35561	—	0.989	P35561 →
F1NHE9	—	0.988	F1NHE9 →
O19182	—	0.988	O19182 →
P52185	—	0.988	P52185 →
Q90854	—	0.988	Q90854 →
Q64273	—	0.987	Q64273 →
P49656	—	0.987	P49656 →
Q9NPI9	—	0.987	Q9NPI9 →
P49658	—	0.986	P49658 →
KCNJ2	Inward rectifier potassium channel 2	0.986	landscape →
P63251	—	0.986	P63251 →
P63253	—	0.986	P63253 →
P63250	—	0.985	P63250 →
Q9MYY9	—	0.985	Q9MYY9 →
P52186	—	0.985	P52186 →
P48542	—	0.985	P48542 →
KCNJ11	ATP-sensitive inward rectifier potassium channel 11	0.985	landscape →
O18839	—	0.985	O18839 →
Q61743	—	0.984	Q61743 →
O02822	—	0.983	O02822 →
Q5NVJ6	—	0.982	Q5NVJ6 →