KIF18B

Kinesin-like protein KIF18B

0 patent compounds predicted against KIF18B, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Germline variants in KIF18B on Sugi Variant → ClinVar classifications, population frequency, and predictor agreement (AlphaMissense, SaProt, REVEL) Full KIF18B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

Clinical trials — most relevant to KIF18B by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Study to Investigate Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy With GenSci122 in Participants With Advanced Solid Tumors	PHASE1	RECRUITING
Phase I Study of Oral BAY 1217389 in Combination With Intravenous Paclitaxel	PHASE1	COMPLETED
Progressive Familial Intrahepatic Cholestasis in Indian Children - Establishing an Indian PFIC Registry	nan	UNKNOWN
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING
Genetic Study of Patients With Primary Ciliary Dyskinesia	nan	COMPLETED
Registry and Natural History of Epilepsy-Dyskinesia Syndromes	nan	RECRUITING
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others	nan	RECRUITING
Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies	nan	RECRUITING
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
Chromosome 18 Clinical Research Center	nan	RECRUITING
Mapping Disease Pathways for Biliary Atresia	nan	RECRUITING
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy	nan	COMPLETED
Evaluation and Treatment of Pediatric, Developmental, and Genetic Eye Diseases	nan	COMPLETED
Delineating the Molecular Spectrum and the Clinical, Imaging and Neuronal Phenotype of Chopra-Amiel-Gordon Syndrome	nan	RECRUITING
Genetics of Pediatric-Onset Motor Neuron and Neuromuscular Diseases	nan	COMPLETED
Gait in Rare Diseases	nan	COMPLETED
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease	nan	UNKNOWN
Clinical Registry Investigating Bardet-Biedl Syndrome	nan	RECRUITING
Long-read Genome Sequencing for the Molecular Diagnosis of Dystonia	nan	RECRUITING
Exploring a Motor Learning Technique Based on the Mirror Motor Neuron System	nan	COMPLETED
Better Delineation of CDK13 Related Phenotype and Epigenetic Signature.	nan	UNKNOWN
PCD New Gene Discovery	nan	COMPLETED
Integrated Model for Promoting Parenting and Early School Readiness in Pediatrics	nan	COMPLETED
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease	nan	RECRUITING
Pediatric Evaluation and Registry for Liver Cholestasis in Canada	nan	RECRUITING
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)	nan	RECRUITING
Hong Kong Spinocerebellar Ataxias Registry	nan	RECRUITING
iPSC Neurons From Adult Survivors of Childhood Cancer Who Have Persistent Vincristine-Induced Neuropathy	nan	COMPLETED
Muscle Tissue Bank for Muscular Dystrophy	nan	COMPLETED
Spastic Paraplegia - Centers of Excellence Research Network	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a KIF18B binder may also engage these)

Protein	Name	Similarity
Q6PFD6	—	0.998	Q6PFD6 →
Q4KLL9	—	0.998	Q4KLL9 →
Q5ZLK6	—	0.995	Q5ZLK6 →
Q2TAC6	—	0.993	Q2TAC6 →
Q8K330	—	0.991	Q8K330 →
Q3ULB5	—	0.990	Q3ULB5 →
Q99PT9	—	0.990	Q99PT9 →
Q5XIS1	—	0.990	Q5XIS1 →
Q80TF6	—	0.990	Q80TF6 →
B7ZNG0	—	0.989	B7ZNG0 →
Q8BHW9	—	0.989	Q8BHW9 →
O89084	—	0.989	O89084 →
Q8CFK6	—	0.989	Q8CFK6 →
Q8BLR5	—	0.988	Q8BLR5 →
Q9Z0E3	—	0.988	Q9Z0E3 →
Q3UIZ8	—	0.988	Q3UIZ8 →
O35071	—	0.987	O35071 →
Q28969	—	0.987	Q28969 →
O35787	—	0.987	O35787 →
Q9D2Z8	—	0.987	Q9D2Z8 →
Q8TB24	—	0.987	Q8TB24 →
O70405	—	0.987	O70405 →
USP19	Ubiquitin carboxyl-terminal hydrolase 19	0.987	landscape →
Q66HE5	—	0.987	Q66HE5 →
Q3UJD6	—	0.987	Q3UJD6 →
Q96FN5	—	0.987	Q96FN5 →
Q8BHL3	—	0.987	Q8BHL3 →
O35231	—	0.986	O35231 →
Q8VDG6	—	0.986	Q8VDG6 →
Q9TUX8	—	0.986	Q9TUX8 →