MAPRE1

Microtubule-associated protein RP/EB family member 1 · Q15691 · MAPRE1 on Sugi Atlas →

0 patent compounds predicted against MAPRE1, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to MAPRE1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU) PHASE2/PHASE3ACTIVE_NOT_RECRUITING
Management of Retinitis Pigmentosa Via Combination of Wharton's Jelly-derived Mesenchymal Stem Cells and Magnovision PHASE3COMPLETED
Comparative Analysis of the Efficacies in Neoadjuvant Chemotherapy of Breast Cancer PHASE3COMPLETED
4D-125 in Patients With X-Linked Retinitis Pigmentosa (XLRP) PHASE1/PHASE2ACTIVE_NOT_RECRUITING
A Phase 1/2, First-in-Human Dose Escalation/Expansion Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of a Subretinal Injection of SB-007 in Subjects With Stargardt Disease (STGD1) PHASE1/PHASE2RECRUITING
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47) PHASE1/PHASE2NOT_YET_RECRUITING
Intravitreal Adalimumab in Inherited and Degenerative Retinal Diseases PHASE1/PHASE2ACTIVE_NOT_RECRUITING
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
Study of Oral Minocycline in Treating Bilateral Cystoid Macular Edema Associated With Retinitis Pigmentosa PHASE1/PHASE2COMPLETED
Subtenon Autologous Platelet-Rich Plasma in Inherited and Degenerative Retinal Diseases PHASE1/PHASE2ACTIVE_NOT_RECRUITING
Memantine Therapy in Amyotrophic Lateral Sclerosis PHASE2COMPLETED
Investigating the Effect of Vitamin A Supplementation on Retinitis Pigmentosa PHASE1COMPLETED
Study of ABT-751 in Patients With Refractory Hematologic Malignancies PHASE1COMPLETED
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases nanUNKNOWN
InsightRP2 Registry nanRECRUITING
Clinical Characterization on PDE6A-related Retinitis Pigmentosa in Preparation to a Gene Therapy Trial nanCOMPLETED
Biomarkers in Retinitis Pigmentosa nanUNKNOWN
Mechanisms of Inherited Retinal Dystrophies Using Whole Genome Sequencing and in Vitro and in Vivo Models nanCOMPLETED
Autophagy Bladder Cancer nanUNKNOWN
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease nanUNKNOWN
Effects of Subtenon-injected Autologous Platelet-rich Plasma on Visual Functions in Eyes With Retinitis Pigmentosa nanCOMPLETED
Identification of New FTLD Genes nanUNKNOWN
Management of Cystoid Macular Edema Secondary to Retinitis Pigmentosa Via Subliminal Micropulse Yellow Laser nanCOMPLETED
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus nanCOMPLETED
Natural History Study of Patients With X-linked Retinal Dystrophy Associated With Mutations in Retinitis Pigmentosa GTPase Regulator (RPGR) nanCOMPLETED
Neurofilament Surveillance Project (NSP) nanACTIVE_NOT_RECRUITING
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) nanRECRUITING
Generating Intervals of Reference FFor Early Life Brain Biomarkers. nanRECRUITING
Retinal Imaging in Patients With Inherited Retinal Degenerations nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a MAPRE1 binder may also engage these)

ProteinNameSimilarity
Q3ZBD9 1.000 Q3ZBD9 →
Q66HR2 1.000 Q66HR2 →
Q61166 1.000 Q61166 →
Q5R7Z5 1.000 Q5R7Z5 →
Q6V291 0.999 Q6V291 →
Q66T82 0.998 Q66T82 →
Q5ZLC7 0.998 Q5ZLC7 →
Q6P848 0.997 Q6P848 →
Q9UPY8 0.965 Q9UPY8 →
Q5XIT1 0.964 Q5XIT1 →
Q6PER3 0.960 Q6PER3 →
Q1ECX4 0.944 Q1ECX4 →
Q9JHS4 0.944 Q9JHS4 →
Q6ZVM7 0.943 Q6ZVM7 →
PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha 0.943 landscape →
DCUN1D1 DCN1-like protein 1 0.943 landscape →
Q9Z269 0.943 Q9Z269 →
Q9QY76 0.942 Q9QY76 →
Q5R7N3 0.942 Q5R7N3 →
Q9QZ73 0.941 Q9QZ73 →
Q6IRE4 0.941 Q6IRE4 →
Q5U2U0 0.940 Q5U2U0 →
Q5ZKU1 0.940 Q5ZKU1 →
O55047 0.940 O55047 →
Q5SRX1 0.940 Q5SRX1 →
CLPX ATP-dependent clpX-like chaperone, mitochondrial 0.939 landscape →
O88506 0.939 O88506 →
Q2KJ46 0.939 Q2KJ46 →
Q863I2 0.939 Q863I2 →
PSMD3 26S proteasome non-ATPase regulatory subunit 3 0.939 landscape →