CLPX

ATP-dependent clpX-like chaperone, mitochondrial · O76031 · CLPX on Sugi Atlas →

230 patent compounds predicted against CLPX, 219 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL12309143	1.00	1/20
SCHEMBL12309166	1.00	1/20
SCHEMBL26519341	1.00	1/20
SCHEMBL19871686	0.86	1/20
SCHEMBL18613194	0.85	1/20
SCHEMBL18615299	0.85	1/20
SCHEMBL11950381	0.85	1/20
SCHEMBL12309142	0.85	1/20
SCHEMBL11950399	0.83	1/20
Withaferin A (SCHEMBL157208)	0.81	1/20
Withaferin A (SCHEMBL11950371)	0.81	1/20
Withaferin A (SCHEMBL12309137)	0.81	1/20
SCHEMBL12309145	0.81	1/20
Withaferin A (SCHEMBL12309163)	0.81	1/20
Withaferin A (SCHEMBL17807718)	0.81	1/20
Withaferin A (SCHEMBL18372363)	0.81	1/20
Withaferin A (SCHEMBL20136632)	0.81	1/20
Withaferin A (SCHEMBL24075907)	0.81	1/20
Withaferin A (SCHEMBL29398581)	0.81	1/20
Withaferin A (SCHEMBL30782710)	0.81	1/20

Clinical trials — most relevant to CLPX by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Clinical Evaluation of the Effect of Metformin in Sepsis	PHASE3	UNKNOWN
Targeting Endoplasmic Reticulum Stress in Human Hypertension	PHASE1/PHASE2	RECRUITING
University of California, San Diego (UCSD) Suramin Autism Treatment-1 (SAT1) Trial	PHASE1/PHASE2	COMPLETED
Biologic Correlative Taxotere/AC	PHASE2	COMPLETED
Arginine Replacement Therapy in COVID-19	PHASE2	RECRUITING
Safety and Pharmacology of SNX-5422 Plus Carboplatin and Paclitaxel in Subjects With Solid Tumors	PHASE1	COMPLETED
HS-201, an HSP90 Inhibitor-linked Verteporfin for Detection of Solid Malignancies	PHASE1	WITHDRAWN
Effectiveness of Light for Enhancement of Cognition by Transcranial Repeated Application (ELECTRA)	EARLY_PHASE1	COMPLETED
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide	nan	RECRUITING
Efficacy and Safety of Deep Cervical Lymph Node-vein Bypass Surgery in ALS Amyotrophic Lateral Sclerosis	nan	NOT_YET_RECRUITING
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence	nan	NOT_YET_RECRUITING
Predicting Pancreatic Necrosis Using mitDNA	nan	UNKNOWN
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy	nan	COMPLETED
Skeletal Muscle Apoptosis and Physical Performance; Oxidative RNA/DNA Damage and Repair in Aged Human Muscle	nan	COMPLETED
Skeletal Muscle Aging and Responsiveness in Aged People With MS	nan	RECRUITING
Innate Immunity in COPD	nan	RECRUITING
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders	nan	RECRUITING
Mitochondrial Function of Immune Cells in Sepsis	nan	COMPLETED
Establishment of Human Cellular Disease Models for Wilson Disease	nan	COMPLETED
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Biological Aging Hallmarks-Guided Integrative TCM and Conventional Medicine in Post-Treatment Unexplained Female Infertility	nan	RECRUITING
Mitoquines in COPD	nan	UNKNOWN
A Feasibility Study: Assessing Photobiomodulation in Myalgic Encephalomyelitis	nan	UNKNOWN
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men	nan	RECRUITING
Exploring Biomarkers in Hereditary Transthyretin Amyloidosis	nan	RECRUITING
Effect of Branched Chain Amino Acids on Muscle	nan	COMPLETED
Human Mitochondrial Stress-driven Obesity Resistance	nan	COMPLETED
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
Exercise Resistance in Type 2 Diabetes	nan	ACTIVE_NOT_RECRUITING
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION

Related proteins — ESM-2 sequence neighbours (a CLPX binder may also engage these)

Protein	Name	Similarity
Q5U2U0	—	1.000	Q5U2U0 →
Q9JHS4	—	1.000	Q9JHS4 →
Q5R7N3	—	1.000	Q5R7N3 →
P11497	—	0.963	P11497 →
Q5SWU9	—	0.962	Q5SWU9 →
Q9TTS3	—	0.960	Q9TTS3 →
Q07866	—	0.960	Q07866 →
Q28559	—	0.960	Q28559 →
Q5R581	—	0.958	Q5R581 →
P11029	—	0.958	P11029 →
Q0J035	—	0.957	Q0J035 →
Q8L5Y9	—	0.957	Q8L5Y9 →
ACACA	Acetyl-CoA carboxylase 1	0.957	landscape →
P37285	—	0.956	P37285 →
Q40281	—	0.954	Q40281 →
P83094	—	0.954	P83094 →
PPME1	Protein phosphatase methylesterase 1	0.953	landscape →
Q9ERG2	—	0.953	Q9ERG2 →
O88506	—	0.952	O88506 →
P93768	—	0.952	P93768 →
UBA2	SUMO-activating enzyme subunit 2	0.952	landscape →
Q5XGS8	—	0.952	Q5XGS8 →
Q68FK8	—	0.951	Q68FK8 →
D2XV59	—	0.951	D2XV59 →
F1LTE0	—	0.951	F1LTE0 →
Q62696	—	0.950	Q62696 →
Q58DN4	—	0.950	Q58DN4 →
Q2KJ46	—	0.950	Q2KJ46 →
Q01587	—	0.950	Q01587 →
Q13033	—	0.950	Q13033 →