MAT1A

S-adenosylmethionine synthase isoform type-1 · Q00266 · MAT1A on Sugi Atlas →

282 patent compounds predicted against MAT1A, 220 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL22093247 SCHEMBL22093247 1.00 1/20
SCHEMBL22093249 SCHEMBL22093249 1.00 1/20
SCHEMBL29569856 SCHEMBL29569856 1.00 1/20
SCHEMBL23549022 SCHEMBL23549022 0.82 1/20
SCHEMBL29569803 SCHEMBL29569803 0.82 1/20
SCHEMBL22093063 SCHEMBL22093063 0.79 1/20
SCHEMBL22093477 SCHEMBL22093477 0.79 1/20
SCHEMBL22103463 SCHEMBL22103463 0.79 1/20
SCHEMBL23583456 SCHEMBL23583456 0.79 1/20
SCHEMBL29571405 SCHEMBL29571405 0.79 1/20
SCHEMBL31145373 SCHEMBL31145373 0.79 1/20
SCHEMBL31145444 SCHEMBL31145444 0.79 1/20
SCHEMBL22103471 SCHEMBL22103471 0.76 1/20
SCHEMBL22103485 SCHEMBL22103485 0.76 1/20
SCHEMBL23548999 SCHEMBL23548999 0.76 1/20
SCHEMBL29570085 SCHEMBL29570085 0.76 1/20
SCHEMBL29570254 SCHEMBL29570254 0.76 1/20
SCHEMBL29570365 SCHEMBL29570365 0.76 1/20
SCHEMBL22093190 SCHEMBL22093190 0.72 1/20
SCHEMBL22093441 SCHEMBL22093441 0.72 1/20

Clinical trials — most relevant to MAT1A by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Folic Acid and Creatine as Therapeutic Approaches for Lowering Blood Arsenic PHASE4COMPLETED
Treatment With Azacitidine of Recurrent Gliomas With IDH1/2 Mutation PHASE2UNKNOWN
Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor PHASE1/PHASE2NOT_YET_RECRUITING
Phase 1/ Phase 2 Study to Assess Safety and Efficacy of Orally Administered JBI-802 in Subjects With Myeloproliferative Neoplasms (MPN) and Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN) With Thrombocytosis PHASE1/PHASE2RECRUITING
Effect of S-adenosylmethionine (SAMe) on Blood Levels of Homocysteine PHASE1COMPLETED
5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People With Advanced Solid Tumors PHASE1RECRUITING
Phase I Trial of 4'-Thio-2'-Deoxycytidine (TdCyd) in Patients With Advanced Solid Tumors PHASE1COMPLETED
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer nanUNKNOWN
Role of a Dietary Supplement in Lowering SAH in Healthy Adults With Elevated Plasma SAH and Normal Homocysteine Levels nanCOMPLETED
Treating Oxidative Stress and the Metabolic Pathology of Autism nanCOMPLETED
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients. nanCOMPLETED
Effect of SAMe Treatment on Recurrence After Radical Treatment of Primary Hepatic Carcinoma nanUNKNOWN
Harmonized Micronutrient Project nanCOMPLETED
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation nanCOMPLETED
Dietary Effects of Sulfur Amino Acids nanCOMPLETED
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart nanUNKNOWN
Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD nanCOMPLETED
Efficacy of Essential Phospholipid Versus Betaine HCL/L-Glutamic Acid in MAFLD nanNOT_YET_RECRUITING
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients nanCOMPLETED
DNA Methylation and Autoimmune Thyroid Diseases nanCOMPLETED
Effectiveness of Comprehensive Tertiary Interventions on Incidence and Clinical Outcomes of Birth Defects nanCOMPLETED
Impact Of Choline in Patients With NAFLD nanUNKNOWN
S-adenosylmethionine Plus Choline in Treatment of Patients With Alcoholic Liver Disease nanUNKNOWN
EnBrace HR for Depression Treatment and Prevention in Women Trying to Conceive and Early Pregnancy nanCOMPLETED
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione nanCOMPLETED
Melatonin in Pregnancy nanCOMPLETED
Proof of Concept Creatine Supplementation for Homocystinuria Study nanACTIVE_NOT_RECRUITING
The Clinical Value of the Nitric Oxide System Components in Asthma and COPD nanUNKNOWN
Adenosylmethionine Metabolism in Human Inflammation nanUNKNOWN
Presence of Cyclopropane Fatty Acids (CPFA) in Human Plasma nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a MAT1A binder may also engage these)

ProteinNameSimilarity
Q2KJC6 1.000 Q2KJC6 →
B7LYX2 1.000 B7LYX2 →
B1XFA4 1.000 B1XFA4 →
C5A0L1 1.000 C5A0L1 →
B1IT65 1.000 B1IT65 →
Q91X83 1.000 Q91X83 →
Q7N119 1.000 Q7N119 →
P66765 1.000 P66765 →
B4TV58 1.000 B4TV58 →
B5BFP7 1.000 B5BFP7 →
B0UWT3 1.000 B0UWT3 →
Q3A388 1.000 Q3A388 →
A5UIU0 1.000 A5UIU0 →
Q95032 1.000 Q95032 →
B5YQD9 1.000 B5YQD9 →
B7N7J5 1.000 B7N7J5 →
B7NI05 1.000 B7NI05 →
Q3YXS9 1.000 Q3YXS9 →
B7LFK4 1.000 B7LFK4 →
A8A481 1.000 A8A481 →
P0A819 1.000 P0A819 →
B7LPQ9 1.000 B7LPQ9 →
Q476V0 1.000 Q476V0 →
A8GIX9 1.000 A8GIX9 →
B5FUK0 1.000 B5FUK0 →
B7UHY9 1.000 B7UHY9 →
P66764 1.000 P66764 →
B6I780 1.000 B6I780 →
Q31WK4 1.000 Q31WK4 →
Q0TDR0 1.000 Q0TDR0 →