MAVS — 68 ClinVar variants
All ClinVar germline MAVS variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 56 flagged for review →
5 Benign · 7 Likely benign · 56 Uncertain significance
Full MAVS gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 56
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAVS p.Ala264Glu Uncertain significance Single submitter
- MAVS p.Ala356Gly Uncertain significance Single submitter
- MAVS p.Ala74Val Uncertain significance Single submitter
- MAVS p.Ala89Val Uncertain significance Single submitter
- MAVS p.Arg102His Uncertain significance Single submitter
- MAVS p.Arg14Cys Uncertain significance Single submitter
- MAVS p.Arg218His Uncertain significance Single submitter
- MAVS p.Arg536Trp Uncertain significance Single submitter
- MAVS p.Arg538His Uncertain significance Single submitter
- MAVS p.Asn473Ser Uncertain significance Single submitter
- MAVS p.Asp199Gly Uncertain significance Single submitter
- MAVS p.Asp276His Uncertain significance Single submitter
- MAVS p.Cys435Ser Uncertain significance Single submitter
- MAVS p.Gln519His Uncertain significance Single submitter
- MAVS p.Gln93Arg Uncertain significance Single submitter
- MAVS p.Glu179Val Uncertain significance Single submitter
- MAVS p.Glu197Lys Uncertain significance Single submitter
- MAVS p.Glu417Asp Uncertain significance Single submitter
- MAVS p.Glu437Gln Uncertain significance Single submitter
- MAVS p.Gly194Ala Uncertain significance Single submitter
- MAVS p.Gly381Glu Uncertain significance Single submitter
- MAVS p.Gly434Val Uncertain significance Single submitter
- MAVS p.Ile12Val Uncertain significance Single submitter
- MAVS p.Ile476Met Uncertain significance Single submitter
- MAVS p.Leu230Pro Uncertain significance Single submitter
- MAVS p.Leu341Pro Uncertain significance Single submitter
- MAVS p.Leu516Val Uncertain significance Single submitter
- MAVS p.Met303Thr Uncertain significance Single submitter
- MAVS p.Pro117Arg Uncertain significance Single submitter
- MAVS p.Pro119Leu Uncertain significance Single submitter
- MAVS p.Pro141Ala Uncertain significance Single submitter
- MAVS p.Pro173Ser Uncertain significance Single submitter
- MAVS p.Pro235Leu Uncertain significance Single submitter
- MAVS p.Pro346Ser Uncertain significance Single submitter
- MAVS p.Pro431Leu Uncertain significance Single submitter
- MAVS p.Pro451Leu Uncertain significance Single submitter
- MAVS p.Pro485Thr Uncertain significance Single submitter
- MAVS p.Pro493Arg Uncertain significance Single submitter
- MAVS p.Ser258Phe Uncertain significance Single submitter
- MAVS p.Ser416Trp Uncertain significance Single submitter
- MAVS p.Ser433Leu Uncertain significance Single submitter
- MAVS p.Thr234Asn Uncertain significance Single submitter
- MAVS p.Thr250Ile Uncertain significance Single submitter
- MAVS p.Thr321Ile Uncertain significance Single submitter
- MAVS p.Thr376Ile Uncertain significance Single submitter
- MAVS p.Thr523Ile Uncertain significance Single submitter
- MAVS p.Val298Met Uncertain significance Single submitter
- MAVS p.Val470Ala Uncertain significance Single submitter
- MAVS p.Val528Leu Uncertain significance Single submitter
- MAVS p.Val533Met Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- MAVS p.Ala85Thr Uncertain significance Single submitter
- MAVS p.Ala85Val Uncertain significance Single submitter
- MAVS p.Arg43Pro Uncertain significance Single submitter
- MAVS p.Glu5Val Uncertain significance Single submitter
- MAVS p.Lys420Asn Uncertain significance Single submitter
- MAVS p.Pro97Leu Uncertain significance Single submitter
All MAVS variants
Benign 5
- c.292+6C>T Multiple submitters
- p.Ala497= Multiple submitters
- p.Gly413Ser Multiple submitters
- p.Pro66= Multiple submitters
- c.292+3G>A Single submitter
Likely benign 7
- p.Gly491= Multiple submitters
- p.Ala210Val Single submitter
- p.Arg14His Single submitter
- p.Arg499Gln Single submitter
- p.Gly422= Single submitter
- p.Val359= Single submitter
- p.Val423Met Single submitter
Uncertain significance 56
- p.Ala264Glu Single submitter ⚠
- p.Ala356Gly Single submitter ⚠
- p.Ala74Val Single submitter ⚠
- p.Ala85Thr Single submitter ⚠
- p.Ala85Val Single submitter ⚠
- p.Ala89Val Single submitter ⚠
- p.Arg102His Single submitter ⚠
- p.Arg14Cys Single submitter ⚠
- p.Arg218His Single submitter ⚠
- p.Arg43Pro Single submitter ⚠
- p.Arg536Trp Single submitter ⚠
- p.Arg538His Single submitter ⚠
- p.Asn473Ser Single submitter ⚠
- p.Asp199Gly Single submitter ⚠
- p.Asp276His Single submitter ⚠
- p.Cys435Ser Single submitter ⚠
- p.Gln519His Single submitter ⚠
- p.Gln93Arg Single submitter ⚠
- p.Glu179Val Single submitter ⚠
- p.Glu197Lys Single submitter ⚠
- p.Glu417Asp Single submitter ⚠
- p.Glu437Gln Single submitter ⚠
- p.Glu5Val Single submitter ⚠
- p.Gly194Ala Single submitter ⚠
- p.Gly381Glu Single submitter ⚠
- p.Gly434Val Single submitter ⚠
- p.Ile12Val Single submitter ⚠
- p.Ile476Met Single submitter ⚠
- p.Leu230Pro Single submitter ⚠
- p.Leu341Pro Single submitter ⚠
- p.Leu516Val Single submitter ⚠
- p.Lys420Asn Single submitter ⚠
- p.Met303Thr Single submitter ⚠
- p.Pro117Arg Single submitter ⚠
- p.Pro119Leu Single submitter ⚠
- p.Pro141Ala Single submitter ⚠
- p.Pro173Ser Single submitter ⚠
- p.Pro235Leu Single submitter ⚠
- p.Pro346Ser Single submitter ⚠
- p.Pro431Leu Single submitter ⚠
- p.Pro451Leu Single submitter ⚠
- p.Pro485Thr Single submitter ⚠
- p.Pro493Arg Single submitter ⚠
- p.Pro97Leu Single submitter ⚠
- p.Ser258Phe Single submitter ⚠
- p.Ser416Trp Single submitter ⚠
- p.Ser433Leu Single submitter ⚠
- p.Thr234Asn Single submitter ⚠
- p.Thr250Ile Single submitter ⚠
- p.Thr321Ile Single submitter ⚠
- p.Thr376Ile Single submitter ⚠
- p.Thr523Ile Single submitter ⚠
- p.Val298Met Single submitter ⚠
- p.Val470Ala Single submitter ⚠
- p.Val528Leu Single submitter ⚠
- p.Val533Met Single submitter ⚠