Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ME3 | Q16798 | 6/20 | 0.42 |
| ▸ | ME2 | P23368 | 5/20 | 0.42 |
| ▸ | ME1 | P48163 | 5/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6399527 | 0.86 | MAPT (0.46) | MAPTKDM4EALDH1A1PKMGAA | |
| SCHEMBL7041242 | 0.85 | MAPT (0.68) | MAPTKDM4EALDH1A1PKMGAA | |
| SCHEMBL3043144 | 0.80 | ALDH1A1 (0.57) | MAPTKDM4EALDH1A1PKMGAA | |
| SCHEMBL657027 | 0.80 | ALDH1A1 (0.57) | MAPTKDM4EALDH1A1PKMGAA | |
| SCHEMBL7106841 | 0.78 | KDM4E (0.61) | MAPTKDM4EALDH1A1PKMGAA | |
| SCHEMBL2947895 | 0.78 | ALDH1A1 (0.58) | MAPTKDM4EALDH1A1PKMGAA | |
| Hydrochloric Acid SCHEMBL11794645 | 0.78 | ALDH1A1 (0.58) | MAPTKDM4EALDH1A1PKMGAA | |
| SCHEMBL20748279 | 0.78 | ALDH1A1 (0.58) | MAPTKDM4EALDH1A1PKMGAA | |
| SCHEMBL4074886 | 0.76 | HTR3E (0.59) | MAPTKDM4EALDH1A1GAAMEN1 | |
| SCHEMBL4064416 | 0.76 | ADRB1 (0.59) | MAPTKDM4EALDH1A1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110230467-A1 | 4,6-DIAMINONICOTINAMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2011-09-22 | — | — | US | disclosed |
| EP-2361902-A1 | 4,6-DIAMINONICOTINAMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2011-08-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230467-A1 | 4,6-DIAMINONICOTINAMIDE COMPOUND | JAK3, JAK2, JAK1 | MAPT 1361/4885KDM4E 1929/4885ALDH1A1 1378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.