MICOS13 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to MICOS13 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Clinical Evaluation of the Effect of Metformin in Sepsis	PHASE3	UNKNOWN
CoQ10 and Exercise for Mitochondrial Dysfunction in Advance Kidney Disease	PHASE3	RECRUITING
Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease	PHASE2	RECRUITING
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)?	PHASE1	UNKNOWN
Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D)	EARLY_PHASE1	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
The Impact of Mitochondrial Dysfunction on Human Bone Cell Metabolism and Remodelling	nan	ACTIVE_NOT_RECRUITING
Development of Novel Therapies for NIDDM	nan	COMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
Choroid Plexus Dysfunction in Neurological Diseases	nan	RECRUITING
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
The Natural History of Mitochondrial Diseases	nan	RECRUITING
Skeletal Muscle Regeneration in Survivors of Critical Illness: How to Prevent Satellite Cell Failure?	nan	RECRUITING
Investigations Into ISCU Myopathy or Iron Sulfur Scaffold U Protein Myopathy	nan	COMPLETED
Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy	nan	RECRUITING
The Genetics of Diabetes in Southern California Chinese Americans	nan	WITHDRAWN
Effect of Diaphragm Stimulation During Surgery	nan	COMPLETED
Natural History in Primary Mitochondrial Myopathies	nan	RECRUITING
Pathogenic Insights and Search for Biomarkers in RFC1-ataxia/CANVAS	nan	RECRUITING
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
Exploring the Relationship Between Androgen Metabolism, Metabolic Disease and Skeletal Muscle Energy Balance in Men	nan	UNKNOWN
Human Mitochondrial Stress-driven Obesity Resistance	nan	COMPLETED
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence	nan	NOT_YET_RECRUITING
Calf Muscle Strength in Mitochondrial Diseases	nan	COMPLETED
Mitochondrial Assessment in Critical Ill Patients in Intensive Care	nan	NOT_YET_RECRUITING
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a MICOS13 binder may also engage these)

Protein	Name	Similarity
Q2ACH7	—	1.000	Q2ACH7 →
Q8R404	—	1.000	Q8R404 →
A1XQR7	—	0.996	A1XQR7 →
Q1LUK1	—	0.977	Q1LUK1 →
Q8BTE5	—	0.970	Q8BTE5 →
Q1RMH3	—	0.967	Q1RMH3 →
Q5R987	—	0.966	Q5R987 →
Q4V8S3	—	0.964	Q4V8S3 →
Q5XFV8	—	0.964	Q5XFV8 →
Q1MTD4	—	0.964	Q1MTD4 →
Q9DCZ4	—	0.964	Q9DCZ4 →
COX14	Cytochrome c oxidase assembly protein COX14	0.964	landscape →
Q8BH51	—	0.964	Q8BH51 →
A8MTT3	—	0.963	A8MTT3 →
Q9MA63	—	0.963	Q9MA63 →
Q8VCR3	—	0.963	Q8VCR3 →
Q9NWH2	—	0.963	Q9NWH2 →
Q148H0	—	0.962	Q148H0 →
P56379	—	0.962	P56379 →
Q68EV8	—	0.961	Q68EV8 →
Q4PLW0	—	0.961	Q4PLW0 →
P24311	—	0.961	P24311 →
Q63ZZ0	—	0.961	Q63ZZ0 →
Q1L9A2	—	0.961	Q1L9A2 →
PLIN3	Perilipin-3	0.961	landscape →
P14790	—	0.960	P14790 →
Q9TUM6	—	0.960	Q9TUM6 →
Q9BUR5	—	0.960	Q9BUR5 →
Q9FNC9	—	0.960	Q9FNC9 →
Q5RAV8	—	0.960	Q5RAV8 →