MLN — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Hydrochloric Acid (SCHEMBL29685937)	1.00	1/20
Hydrochloric Acid (SCHEMBL30314075)	1.00	1/20
SCHEMBL23683049	0.98	1/20
SCHEMBL29349792	0.98	1/20
SCHEMBL29628952	0.98	1/20
SCHEMBL20472695	0.84	1/20
SCHEMBL20472697	0.84	1/20
SCHEMBL3136630	0.45	1/20
SCHEMBL13221503	0.45	1/20
SCHEMBL3035844	0.44	1/20
SCHEMBL13221516	0.44	1/20
SCHEMBL13221520	0.42	1/20
SCHEMBL3032381	0.42	1/20

Clinical trials — most relevant to MLN by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Effect of Combination of Mosapride and DPP-4 Inhibitor on Plasma Concentration of Incretin Hormones	PHASE4	COMPLETED
Clinical Effect of Rebamipide on Chronic Gastritis	PHASE4	COMPLETED
Effect of Using Azithromycin Versus Placebo With Dexamethasone in Prevention of Post-spinal Nausea and Vomiting.	PHASE4	UNKNOWN
Clinical Trial to Assess the Efficacy and Safety of Combination Therapy of Motireb 5/100 mg in Functional Dyspepsia Patients.	PHASE3	UNKNOWN
Melatonin Associated to Acid Inhibition for Chemoprevention in Barret Esophagus: a Pilot Study	PHASE3	COMPLETED
Incretin Effect and Use After Clinical Islet Transplantation	PHASE2	COMPLETED
Evaluating the Safety and Efficacy of Romidepsin in Combination With Antiretroviral Therapy in HIV-Infected Adults With Suppressed Viral Load	PHASE1/PHASE2	COMPLETED
Treatment of Acute Migraine Headache in Children	PHASE2	COMPLETED
Sitagliptin in the Elderly	PHASE2	COMPLETED
A Study to Assess the Safety and Efficacy of LB-P8 in Patients With PSC	PHASE2	RECRUITING
Effect of GSK962040 on Oesophageal Function	PHASE1	COMPLETED
Effect of Food on the Pharmacokinetics of Oral Semaglutide in Healthy Subjects	PHASE1	COMPLETED
A Study to Evaluate the Pharmacokinetics and Absolute Bioavailability of GSK962040 Given as an Oral Dose Simultaneously With an Intravenous Microtracer Dose of [14C]-GSK962040 in Healthy Volunteers	PHASE1	COMPLETED
Ph1 Volasertib Plus Romidepsin in R/R PTCL and CTCL	PHASE1	WITHDRAWN
Clinical Trial of Intranasal Delivery of NT-301	PHASE1	COMPLETED
Romidepsin and Parsaclisib for the Treatment of Relapsed or Refractory T-Cell Lymphomas	PHASE1	COMPLETED
A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion	EARLY_PHASE1	RECRUITING
The Effect of taVNS and Upper GI Motility	nan	RECRUITING
Gut Hormones and Nutritional Status After a Standardized Meal.	nan	COMPLETED
Ghrelin and Gastric Emptying in Children With Functional Dyspepsia	nan	COMPLETED
Gut Peptides and Bone Remodeling in Individuals With Spinal Cord Injury	nan	UNKNOWN
Beta-cell Response to Incretin Hormones in Cystic Fibrosis	nan	RECRUITING
Laparoscopic Single Anastomosis Sleeve Ileal Bypass Versus Laparoscopic Sleeve Gastrectomy For Morbidly Obese Patients	nan	UNKNOWN
Effect of Chronic Incretin-based Therapy in Cystic Fibrosis	nan	COMPLETED
Efficacy and Akathisia Incidence of Slow Infusion Metoclopramide	nan	COMPLETED
Effects of Green Banana BIOmass Consumption in Patients With Pre-diabetes and Diabetes MELlitus (The BIOMEL Study)	nan	UNKNOWN
Endoscopic Gastric Reduction of Gastric Mucosa in Obesity	nan	UNKNOWN
Fatigue and Quality of Life in Patients With Neuroendocrine Neoplasia	nan	UNKNOWN
Effects of Colesevelam HCl On Bile Acid Kinetics	nan	COMPLETED
Extended Mesenteric Resection in Ileocecal Crohn's Disease.	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a MLN binder may also engage these)

Protein	Name	Similarity
P13438	—	0.997	P13438 →
O62820	—	0.996	O62820 →
A0A0D1E6R6	—	0.996	A0A0D1E6R6 →
P0DN50	—	0.995	P0DN50 →
Q566V9	—	0.995	Q566V9 →
P58440	—	0.995	P58440 →
A0A3G1VU77	—	0.995	A0A3G1VU77 →
Q8IN43	—	0.994	Q8IN43 →
A0A023W082	—	0.994	A0A023W082 →
Q99LS0	—	0.994	Q99LS0 →
Q8SWP0	—	0.994	Q8SWP0 →
Q9BP65	—	0.994	Q9BP65 →
P0CK62	—	0.994	P0CK62 →
Q6PTD6	—	0.994	Q6PTD6 →
Q9XSE2	—	0.994	Q9XSE2 →
Q80WL2	—	0.993	Q80WL2 →
D0NMF4	—	0.993	D0NMF4 →
Q96SK2	—	0.993	Q96SK2 →
C5DVG0	—	0.993	C5DVG0 →
Q9LEZ4	—	0.993	Q9LEZ4 →
Q99MP5	—	0.993	Q99MP5 →
P27114	—	0.993	P27114 →
Q09401	—	0.993	Q09401 →
Q9BPH9	—	0.993	Q9BPH9 →
Q1EG28	—	0.993	Q1EG28 →
C4YAT5	—	0.992	C4YAT5 →
P20394	—	0.992	P20394 →
P0CJ02	—	0.992	P0CJ02 →
Q9NDA5	—	0.992	Q9NDA5 →
P02659	—	0.992	P02659 →