Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lomitapide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP known ✓ | P55157 | 15/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.93 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.93 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.93 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.93 |
| ▸ | DRD1 | P21728 | 1/20 | 0.93 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.93 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.93 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.93 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.93 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.93 |
| ▸ | DRD3 | P35462 | 1/20 | 0.93 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.93 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.93 |
| ▸ | MTR | Q99707 | 1/20 | 0.93 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lomitapide SCHEMBL29367678 | 1.00 | MTTP (1.00) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| Lomitapide SCHEMBL304604 | 0.96 | MTTP (1.00) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| Lomitapide SCHEMBL29355521 | 0.96 | MTTP (1.00) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL16519940 | 0.92 | MTTP (0.88) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL17460357 | 0.91 | MTTP (0.83) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL19500371 | 0.90 | MTTP (0.85) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL12588085 | 0.90 | MTTP (0.85) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL8901728 | 0.90 | MTTP (0.85) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL19509698 | 0.90 | MTTP (0.88) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL6600443 | 0.89 | MTTP (0.86) | MTTPCHRM2ADRA2AADORA3CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017098522-A1 | CRYSTALLINE POLYMORPH OF N-(2,2,2-TRIFLUOROETHYL-9-[4-[R4-R[[[I4'- (TRIFLUOROMETHYL) [ 1,1 ' -BIPHENYL] -2-YL] CARBONYL] AMINO] -1 -PIPERIDINYL] BUTYL] -9H- FLUORENE-9-CARBOXAMIDE METHANESULFONATE AND PROCESS FOR PREPARATION THEREOF | MSN LABORATORIES PRIVATE LIMITED (IN) | 2017-06-15 | — | — | WO | claimed |
| WO-2017098522-A1 | CRYSTALLINE POLYMORPH OF N-(2,2,2-TRIFLUOROETHYL-9-[4-[R4-R[[[I4'- (TRIFLUOROMETHYL) [ 1,1 ' -BIPHENYL] -2-YL] CARBONYL] AMINO] -1 -PIPERIDINYL] BUTYL] -9H- FLUORENE-9-CARBOXAMIDE METHANESULFONATE AND PROCESS FOR PREPARATION THEREOF | MSN LABORATORIES PRIVATE LIMITED (IN) | 2017-06-15 | — | — | WO | disclosed |
| US-20160083345-A1 | POLYMORPHIC FORMS OF LOMITAPIDE AND ITS SALTS AND PROCESSES FOR THEIR PREPARATION | CADILA HEALTHCARE LIMITED (IN) | 2016-03-24 | — | — | US | disclosed |
| US-9000175-B2 | Bicyclic GPR119 modulators | LUPIN LIMITED (IN) | 2015-04-07 | — | — | US | disclosed |
| US-20130245000-A1 | BICYCLIC GPR119 MODULATORS | LUPIN LIMITED (IN) | 2013-09-19 | — | — | US | disclosed |
| WO-2012025811-A1 | INDOLYLPYRIMIDINES AS MODULATORS OF GPR119 | LUPIN LIMITED (IN) | 2012-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160083345-A1 | POLYMORPHIC FORMS OF LOMITAPIDE AND ITS SALTS AND PROCESSES FOR THEIR PREPARATION | LIPA, CETP, MTTP | MTTP 3/4885CHRM2 1677/4885ADRA2A 125/4885 |
| US-20130245000-A1 | BICYCLIC GPR119 MODULATORS | GPR119, GPR180, GPBAR1 | MTTP 656/4885CHRM2 291/4885ADRA2A 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.