MYH10 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Quizartinib (SCHEMBL72923)	1.00	1/20
SCHEMBL4330339	1.00	1/20
SCHEMBL4330341	1.00	1/20
SCHEMBL15919292	1.00	1/20
Quizartinib (SCHEMBL74121)	0.99	1/20
Quizartinib (SCHEMBL742377)	0.99	1/20
SCHEMBL73633	0.93	1/20
Hydrochloric Acid (SCHEMBL3453696)	0.92	1/20
SCHEMBL72924	0.91	1/20
Hydrochloric Acid (SCHEMBL74122)	0.90	1/20
Hydrochloric Acid (SCHEMBL742748)	0.90	1/20
SCHEMBL769118	0.89	1/20
SCHEMBL769608	0.89	1/20
SCHEMBL769721	0.89	1/20
SCHEMBL73035	0.88	1/20
SCHEMBL73476	0.88	1/20
SCHEMBL769326	0.88	1/20
SCHEMBL770185	0.88	1/20
SCHEMBL1759071	0.88	1/20
SCHEMBL1759297	0.88	1/20

Clinical trials — most relevant to MYH10 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Lifestyle and Pharmacological Interventions in Hypertrophic Cardiomyopathy	PHASE2/PHASE3	COMPLETED
Empagliflozin in Hypertrophic Cardiomyopathy	PHASE3	ACTIVE_NOT_RECRUITING
The Effect of Neuromuscular Electrical Stimulation (NMES)	PHASE2	COMPLETED
Sacubitril/Valsartan vs Lifestyle in Hypertrophic Cardiomyopathy	PHASE2	COMPLETED
Evaluating MED2005 & Nitrostat Bioavailability	PHASE1	COMPLETED
Transcutaneous Functional Magnetic Muscle Stimulation in Critically Ill	nan	UNKNOWN
Phenotypic and Genotypic Identification and Characterization of MYH9-related Constitutional Thrombocytopenia	nan	COMPLETED
Mapping of End Stage Renal Disease Genetic Susceptibility in African Americans by Admixture Linkage Disequilibrium	nan	COMPLETED
Characteristics of Nondystrophic Myotonias	nan	COMPLETED
Chronic Muscle Disuse in the Elderly	nan	COMPLETED
Molecular and Genetic Studies of Congenital Myopathies	nan	RECRUITING
The Muscle in Cerebral Palsy; Sarcomere Length in Vivo and Microscopic Characterization of Biopsies.	nan	RECRUITING
Natural History Study for Patients With Nemaline Myopathy in Belgium	nan	NOT_YET_RECRUITING
New Diagnostic Strategy in Hypertrophic Cardiomyopathy	nan	UNKNOWN
Phenotype - Genotype Correlation in a Sample of Egyptian Patients With Congenital Myopathies and Congenital Muscular Dystrophies	nan	RECRUITING
Muscle Tissue Bank for Muscular Dystrophy	nan	COMPLETED
Improvement of DIAgnostic and Phenotype-genotype Correlation Studies in Patients With MYOpathy Suspected of TITinopathy	nan	UNKNOWN
Pediatric Cardiomyopathy Mutation Analysis	nan	RECRUITING
Regulation of Muscle Protein Phenotype in Humans With Obesity	nan	COMPLETED
3D-Microscopic Muscle Architecture in Cerebral Palsy	nan	RECRUITING
Role of Ultrasound in Diagnosis of Muscle Diseases	nan	COMPLETED
Genetics of Cardiovascular and Neuromuscular Disease	nan	RECRUITING
Signs and Symptoms Associated With Molecular Defects in Genetically Inherited Heart Disease	nan	COMPLETED
Registry of Unexplained Cardiac Arrest	nan	COMPLETED
Effect of Exercise on the Human Skeletal Muscle Phosphoproteome	nan	COMPLETED
Signs and Symptoms of Genetic Abnormalities Linked to Inherited Heart Disease	nan	COMPLETED
Heart and Skeletal Muscle Problems in Neuroacanthocytosis	nan	COMPLETED
Recovery From 50 Eccentric Biceps Curls in Young, Untrained Men and Women	nan	COMPLETED
Genetic Analysis of African-Americans With High Blood Pressure	nan	COMPLETED
Predictive Factors and Consequences of Myocardial Fibrosis in Hypertrophic Cardiomyopathy	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a MYH10 binder may also engage these)

Protein	Name	Similarity
Q27991	—	1.000	Q27991 →
Q61879	—	1.000	Q61879 →
Q9JLT0	—	1.000	Q9JLT0 →
P14105	—	1.000	P14105 →
Q8VDD5	—	1.000	Q8VDD5 →
P35749	—	1.000	P35749 →
Q258K2	—	1.000	Q258K2 →
MYH9	Myosin-9	1.000	landscape →
O08638	—	0.999	O08638 →
P10587	—	0.999	P10587 →
Q62812	—	0.998	Q62812 →
P35748	—	0.998	P35748 →
Q9BE39	—	0.992	Q9BE39 →
P02564	—	0.991	P02564 →
P49824	—	0.991	P49824 →
Q63862	—	0.989	Q63862 →
Q9TV62	—	0.989	Q9TV62 →
Q8MJV1	—	0.989	Q8MJV1 →
Q9TV63	—	0.989	Q9TV63 →
P79293	—	0.988	P79293 →
P13533	—	0.988	P13533 →
P12883	—	0.988	P12883 →
P13540	—	0.988	P13540 →
Q99323	—	0.988	Q99323 →
Q076A7	—	0.987	Q076A7 →
G3UW82	—	0.987	G3UW82 →
P13542	—	0.987	P13542 →
Q9TV61	—	0.987	Q9TV61 →
P11055	—	0.987	P11055 →
Q9BE40	—	0.987	Q9BE40 →