MYO1G — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Molibresib (SCHEMBL1872390)	1.00	1/20
Molibresib (SCHEMBL12671490)	1.00	1/20
Molibresib (SCHEMBL12966358)	1.00	1/20
SCHEMBL9998851	0.91	1/20
SCHEMBL14756282	0.88	1/20
SCHEMBL12966165	0.87	1/20
SCHEMBL14756215	0.87	1/20
SCHEMBL14756339	0.87	1/20
SCHEMBL9998825	0.86	1/20
SCHEMBL1874116	0.85	1/20
SCHEMBL12671221	0.85	1/20
SCHEMBL14756021	0.85	1/20
SCHEMBL14756240	0.85	1/20
SCHEMBL14756287	0.85	1/20
SCHEMBL14756335	0.85	1/20
SCHEMBL14756409	0.85	1/20
SCHEMBL15969460	0.85	1/20
SCHEMBL15969471	0.85	1/20
SCHEMBL14756206	0.84	1/20
SCHEMBL14756217	0.84	1/20

Clinical trials — most relevant to MYO1G by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure	PHASE2	COMPLETED
Combined N-of-1 Trials Mexiletine vs Placebo in Patients With Non-Dystrophic Myotonia (NDM)	PHASE2	COMPLETED
Transcutaneous Functional Magnetic Muscle Stimulation in Critically Ill	nan	UNKNOWN
Genetic Testing in Primary Congenital Glaucoma Patients	nan	UNKNOWN
Phenotypic and Genotypic Identification and Characterization of MYH9-related Constitutional Thrombocytopenia	nan	COMPLETED
A Multicenter Phenotype-Genotype Analysis of LGMD Patients in China	nan	ENROLLING_BY_INVITATION
CRISPR/Cas9 Instantaneous Gene Editing Therapy to Intraocular Hypertensive POAG With MYOC Mutation	nan	RECRUITING
Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure	nan	RECRUITING
Signs and Symptoms of Genetic Abnormalities Linked to Inherited Heart Disease	nan	COMPLETED
Muscle Tissue Bank for Muscular Dystrophy	nan	COMPLETED
Clinical and Genetic Studies in Families With Myopia and Related Diseases	nan	COMPLETED
Spinal Muscular Atrophy (SMA) Biomarkers Study in the Immediate Postnatal Period of Development	nan	COMPLETED
Characteristics of Nondystrophic Myotonias	nan	COMPLETED
Family Myopia Study	nan	COMPLETED
Contractile Cross Sectional Areas and Muscle Strength in Patients With Congenital Myopathies	nan	COMPLETED
Phenotype - Genotype Correlation in a Sample of Egyptian Patients With Congenital Myopathies and Congenital Muscular Dystrophies	nan	RECRUITING
Clinical and Genetic Examinations of Dilated Cardiomyopathy	nan	COMPLETED
A Single Center Prospective Study in an Estimated 570 Patients Who Underwent Genetic Screening at UZ Brussel in the Context of a Primary Cardiac Arrhythmia. Patients Showing a Variant Class 3,4 or 5 in SCN4A or CLCN1 Will Undergo a Clinical and Electrophysiological Review After IC.	nan	NOT_YET_RECRUITING
Congenital Muscle Disease Study of Patient and Family Reported Medical Information	nan	RECRUITING
Genetic Analysis of African-Americans With High Blood Pressure	nan	COMPLETED
Mapping of End Stage Renal Disease Genetic Susceptibility in African Americans by Admixture Linkage Disequilibrium	nan	COMPLETED
Clinical and Functional Assessment of Patients With Inherited Non-Duchenne Myopathies in Sohag University Hospital	nan	RECRUITING
Characteristics of Idiopathic Familial Voice Disorders	nan	COMPLETED
Whole-exome Sequencing in Childhood Obesity	nan	COMPLETED
The Role of Muscle Protein Breakdown in the Regulation of Muscle Quality in Frail Elderly Individuals	nan	COMPLETED
Signs and Symptoms Associated With Molecular Defects in Genetically Inherited Heart Disease	nan	COMPLETED
The Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study	nan	UNKNOWN
Molecular and Genetic Studies of Congenital Myopathies	nan	RECRUITING
GARM II: A Study on the Genetics of Age-related Maculopathy	nan	ACTIVE_NOT_RECRUITING
Genomewide Screening of Pathological Myopia	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a MYO1G binder may also engage these)

Protein	Name	Similarity
Q5SUA5	—	1.000	Q5SUA5 →
Q5ZMC2	—	0.996	Q5ZMC2 →
Q8N1T3	—	0.990	Q8N1T3 →
Q9HD67	—	0.987	Q9HD67 →
D3ZJP6	—	0.986	D3ZJP6 →
Q13402	—	0.985	Q13402 →
Q29P71	—	0.984	Q29P71 →
A5PF48	—	0.984	A5PF48 →
A2AQP0	—	0.984	A2AQP0 →
F8VQB6	—	0.983	F8VQB6 →
Q23979	—	0.983	Q23979 →
Q6GPA1	—	0.982	Q6GPA1 →
Q03479	—	0.982	Q03479 →
O94832	—	0.981	O94832 →
Q9V3Z6	—	0.981	Q9V3Z6 →
Q9WTI7	—	0.981	Q9WTI7 →
Q6PIF6	—	0.981	Q6PIF6 →
E7F9L8	—	0.981	E7F9L8 →
A7E2Y1	—	0.981	A7E2Y1 →
Q23978	—	0.981	Q23978 →
Q5SYD0	—	0.981	Q5SYD0 →
O00934	—	0.981	O00934 →
Q27966	—	0.981	Q27966 →
F1PRN2	—	0.980	F1PRN2 →
Q6ZSI9	—	0.980	Q6ZSI9 →
P79114	—	0.980	P79114 →
Q5R607	—	0.979	Q5R607 →
DHX30	ATP-dependent RNA helicase DHX30	0.978	landscape →
Q99MZ6	—	0.978	Q99MZ6 →
Q767K6	—	0.978	Q767K6 →