NARS1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to NARS1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Treatment of Wolfram Syndrome Type 2 With the Chelator Deferiprone and Incretin Based Therapy	PHASE2/PHASE3	UNKNOWN
Effects of Vitamin B3 in Patients With Ataxia Telangiectasia	PHASE2	COMPLETED
Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) and Parkinson's Disease (PD) Patients	PHASE2	COMPLETED
Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC	PHASE2	COMPLETED
Natural History Study of Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL)	nan	RECRUITING
Impact of Mutations in Aminoacyl tRNA Synthetases on Protein Translation and Cellular Stress	nan	WITHDRAWN
Quantifying Disease Progression in LBSL	nan	UNKNOWN
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside	nan	UNKNOWN
SRT in Comparison to ERT on Immune Aspects and Bone Involvement in Gaucher Disease	nan	UNKNOWN
Natural History Study of FDXR Mutation-related Mitochondriopathy	nan	COMPLETED
Protein Synthesis in the Brain of Patients With Fragile X Syndrome	nan	COMPLETED
Genetic Analysis of Fraser Syndrome and Fryns Syndrome	nan	COMPLETED
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)	nan	COMPLETED
Screening of Lysosomal Storage Disorders Diseases in Minority Groups	nan	UNKNOWN
Correlation of Polymorphisms of Lipoprotein Lipase (LpL) and Apolipoprotein E (Apo E) With Lipid Profile of Children With Acute Lymphoblastic Eukaemia During Therapy With L - Asparaginase.	nan	UNKNOWN
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide	nan	RECRUITING
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Role of Sorcin and Annexin A3 in Breast Cancer Patients	nan	UNKNOWN
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes	nan	RECRUITING
Sirtuin1 in COVID19 Patients	nan	UNKNOWN
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip	nan	COMPLETED
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
The Role of Ectopic Fat and Heart Attack Risk in HIV	nan	RECRUITING
The Impact of Mitochondrial Dysfunction on Human Bone Cell Metabolism and Remodelling	nan	ACTIVE_NOT_RECRUITING
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence	nan	NOT_YET_RECRUITING
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease	nan	RECRUITING
Triheptanoin (UX007) to Treat Citrate Transporter Deficiency	nan	NO_LONGER_AVAILABLE
Drug Repurposing for Mitochondrial Disorders Using iPSCs Derived Neural Cells	nan	RECRUITING
Investigate eNAMPT in Multiple Myeloma Biology and Establish Its Role in Disease Progression	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a NARS1 binder may also engage these)

Protein	Name	Similarity
Q8BP47	—	1.000	Q8BP47 →
Q2KJG3	—	1.000	Q2KJG3 →
Q4R4Z1	—	0.997	Q4R4Z1 →
P10723	—	0.996	P10723 →
Q6BU46	—	0.994	Q6BU46 →
Q19722	—	0.992	Q19722 →
Q9SSK1	—	0.992	Q9SSK1 →
O94567	—	0.990	O94567 →
A7GTK8	—	0.990	A7GTK8 →
Q0HUL3	—	0.989	Q0HUL3 →
Q6MEC9	—	0.989	Q6MEC9 →
A0KXL6	—	0.988	A0KXL6 →
A5IE87	—	0.988	A5IE87 →
Q481G3	—	0.988	Q481G3 →
Q5WUG0	—	0.988	Q5WUG0 →
Q6F0Y5	—	0.988	Q6F0Y5 →
Q5X300	—	0.988	Q5X300 →
Q99MN1	—	0.988	Q99MN1 →
Q7UHE1	—	0.988	Q7UHE1 →
Q6HCW9	—	0.988	Q6HCW9 →
A1S684	—	0.988	A1S684 →
Q0HIB6	—	0.988	Q0HIB6 →
Q9M084	—	0.987	Q9M084 →
A4Y6E4	—	0.987	A4Y6E4 →
A1RK52	—	0.987	A1RK52 →
Q8SQK8	—	0.987	Q8SQK8 →
Q8EEZ1	—	0.987	Q8EEZ1 →
Q554D9	—	0.987	Q554D9 →
Q5E5P2	—	0.987	Q5E5P2 →
Q1CGI7	—	0.987	Q1CGI7 →