NDUFAF4

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 · Q9P032 · NDUFAF4 on Sugi Atlas →

839 patent compounds predicted against NDUFAF4, 459 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL15258558	0.76	8/20
R-(+)-Marmin (SCHEMBL27804600)	0.83	7/20
R-(+)-Marmin (SCHEMBL29353819)	0.83	7/20
R-(+)-Marmin (SCHEMBL29625637)	0.83	7/20
SCHEMBL12362713	0.77	7/20
SCHEMBL15080621	0.77	7/20
SCHEMBL12362702	0.73	7/20
SCHEMBL31179835	0.59	7/20
SCHEMBL31397586	0.53	7/20
SCHEMBL31000416	0.78	6/20
SCHEMBL12362734	0.60	6/20
SCHEMBL12362700	0.57	6/20
SCHEMBL13973668	0.47	6/20
SCHEMBL16316892	0.47	6/20
Auraptene (SCHEMBL2535029)	1.00	5/20
Auraptene (SCHEMBL2535034)	1.00	5/20
Umbelliprenin (SCHEMBL18265478)	0.98	5/20
Umbelliprenin (SCHEMBL26641528)	0.98	5/20
Umbelliprenin (SCHEMBL28133292)	0.98	5/20
SCHEMBL29999425	0.83	5/20

Clinical trials — most relevant to NDUFAF4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease	PHASE3	COMPLETED
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
A Study to Evaluate Vitamin B3 Derivative to Treat Mitochondrial Myopathy	PHASE2	ACTIVE_NOT_RECRUITING
Parkinson's Disease Treatment With Coenzyme Q10	PHASE2	COMPLETED
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)	PHASE1/PHASE2	NOT_YET_RECRUITING
Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease	PHASE2	COMPLETED
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)?	PHASE1	UNKNOWN
MABs Therapy m.3243A>G Mutation Carriers	PHASE1	COMPLETED
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine	nan	COMPLETED
Evaluation of Impact of Disease and Visual Disability on Quality of Life and Loss of Independence of Patients Living in France With Leber's Hereditary Optic Neuropathy (LHON) Through Qualitative and Quantitative Data Collection	nan	COMPLETED
The Natural History of Mitochondrial Diseases	nan	RECRUITING
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
Diagnostic Odyssey Survey 2	nan	COMPLETED
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability.	nan	UNKNOWN
Natural History in Primary Mitochondrial Myopathies	nan	RECRUITING
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders	nan	COMPLETED
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip	nan	COMPLETED
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases	nan	RECRUITING
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction	nan	COMPLETED
Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
The Genetics of Diabetes in Southern California Chinese Americans	nan	WITHDRAWN
Ccf mtDNA as a Neurodegenerative Biomarker	nan	UNKNOWN
EPI-743 for Mitochondrial Respiratory Chain Diseases	nan	NO_LONGER_AVAILABLE
Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants	nan	RECRUITING
Coenzyme Q10 Plus NADH Supplementation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a NDUFAF4 binder may also engage these)

Protein	Name	Similarity
Q5R4R9	—	1.000	Q5R4R9 →
A4FUH5	—	1.000	A4FUH5 →
Q9NQR8	—	0.999	Q9NQR8 →
Q9D1H6	—	0.997	Q9D1H6 →
Q9VH39	—	0.991	Q9VH39 →
P34748	—	0.983	P34748 →
A9UMQ3	—	0.982	A9UMQ3 →
Q6BY05	—	0.982	Q6BY05 →
Q09867	—	0.981	Q09867 →
Q21939	—	0.981	Q21939 →
B3MGU5	—	0.981	B3MGU5 →
Q9HDW4	—	0.980	Q9HDW4 →
A6ZND9	—	0.980	A6ZND9 →
B3LIY9	—	0.980	B3LIY9 →
Q9W549	—	0.980	Q9W549 →
A5DT64	—	0.980	A5DT64 →
Q9M358	—	0.980	Q9M358 →
Q86IZ2	—	0.980	Q86IZ2 →
Q61733	—	0.980	Q61733 →
B5DZ31	—	0.980	B5DZ31 →
Q09261	—	0.980	Q09261 →
Q3E705	—	0.980	Q3E705 →
O74988	—	0.979	O74988 →
P82925	—	0.979	P82925 →
Q7JWG9	—	0.979	Q7JWG9 →
B4P2P8	—	0.979	B4P2P8 →
B1P1W2	—	0.979	B1P1W2 →
Q04907	—	0.979	Q04907 →
P19736	—	0.979	P19736 →
A8XY47	—	0.979	A8XY47 →