Auraptene

Auraptene

SCHEMBL2535029

CC(C)=CCC/C(C)=C/COc1ccc2ccc(=O)oc2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALOX15 P16050 5/20 1.00
▸ NDUFS8 O00217 5/20 1.00
▸ COXFA4 O00483 5/20 1.00
▸ NDUFAB1 O14561 5/20 1.00
▸ NDUFA1 O15239 5/20 1.00
▸ NDUFS4 O43181 5/20 1.00
▸ NDUFB5 O43674 5/20 1.00
▸ NDUFB3 O43676 5/20 1.00
▸ NDUFC1 O43677 5/20 1.00
▸ NDUFA2 O43678 5/20 1.00
▸ NDUFS5 O43920 5/20 1.00
▸ NDUFS7 O75251 5/20 1.00
▸ NDUFS2 O75306 5/20 1.00
▸ NDUFS6 O75380 5/20 1.00
▸ NDUFB1 O75438 5/20 1.00
▸ NDUFS3 O75489 5/20 1.00
▸ NDUFB6 O95139 5/20 1.00
▸ NDUFA3 O95167 5/20 1.00
▸ NDUFB4 O95168 5/20 1.00
▸ NDUFB8 O95169 5/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Auraptene SCHEMBL2535034 1.00 ALOX15 (1.00) ALOX15NDUFS8COXFA4NDUFAB1NDUFA1
Umbelliprenin SCHEMBL28133292 0.99 ALOX15 (1.00) ALOX15NDUFS8COXFA4NDUFAB1NDUFA1
Umbelliprenin SCHEMBL18265478 0.99 ALOX15 (1.00) ALOX15NDUFS8COXFA4NDUFAB1NDUFA1
Umbelliprenin SCHEMBL26641528 0.99 ALOX15 (1.00) ALOX15NDUFS8COXFA4NDUFAB1NDUFA1
SCHEMBL17898120 0.92 ALOX15 (1.00) ALOX15NDUFS8COXFA4NDUFAB1NDUFA1
SCHEMBL17898118 0.92 ALOX15 (1.00) ALOX15NDUFS8COXFA4NDUFAB1NDUFA1
SCHEMBL17898119 0.91 ALOX15 (1.00) ALOX15NDUFS8COXFA4NDUFAB1NDUFA1
SCHEMBL17898115 0.91 ALOX15 (1.00) ALOX15NDUFS8COXFA4NDUFAB1NDUFA1
SCHEMBL17898114 0.91 ALOX15 (1.00) ALOX15NDUFS8COXFA4NDUFAB1NDUFA1
SCHEMBL17898117 0.91 ALOX15 (1.00) ALOX15NDUFS8COXFA4NDUFAB1NDUFA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 275 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4714440-A2 A HEALING HERBAL-MINERAL COMPOSITION WITH ENHANCED EFFECTS Kurek, Janusz (PL) 2026-03-25 — — EP claimed
EP-4615506-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES Sahin, Fikret (TR) 2025-09-17 — — EP claimed
EP-4580612-A1 USE OF NRF2 ACTIVATORS FOR THE TREATMENT OF CEREBRAL SMALL VESSEL DISEASE Institut National de la Santé et de la Recherche Médicale (FR) 2025-07-09 — — EP claimed
WO-2024258363-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES SAHIN FIKRET (TR) 2024-12-19 — — WO claimed
WO-2024172325-A1 COMPOSITION CONTAINING PONCIRI FRUCTUS EXTRACT FOR PREVENTING OR TREATING MUSCLE DISEASE 한국과학기술연구원 2024-08-22 — — WO claimed
CN-118344322-A Method for separating high-purity auraptene from ferula gum 上海致臻志臣科技有限公司 2024-07-16 — — CN claimed
WO-2024047248-A1 USE OF NRF2 ACTIVATORS FOR THE TREATMENT OF CEREBRAL SMALL VESSEL DISEASE Institut National de la Santé et de la Recherche Médicale (FR) 2024-03-07 — — WO claimed
CN-116577437-A Method for measuring content of effective components of immature bitter orange 泸州市市场检验检测中心 2023-08-11 — — CN claimed
CN-116548270-A Method for promoting anthurium to release monoterpene beta-ocimene 玉林师范学院 2023-08-08 — — CN claimed
US-20230101403-A1 METHOD OF TREATING OR AMELIORATING CANCERS DRIVEN BY RECEPTOR TYROSINE KINASE FUSION ONCOGENES, AND COMPOSITIONS FOR THE SAME UNIV PENNSYLVANIA (US) 2023-03-30 — — US claimed
CN-112852733-B Application of levisticin A in preparation of medicine for in vitro amplification of human hematopoietic stem cells 南开大学 2022-11-25 — — CN claimed
EP-4072558-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF INFLAMMATION WITH STEROIDS AND A MODULATOR Buzzelet Development And Technologies Ltd (IL) 2022-10-19 — — EP claimed
CN-114874199-A Method for simultaneously preparing epoxy auraptene and epoxy bergamottin 集美大学 2022-08-09 — — CN claimed
US-11266626-B2 Reduction of ER-MAM-localized APP-C99 and methods of treating alzheimer's disease THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2022-03-08 — — US claimed
EP-3324951-B1 PERITONEAL THERAPEUTIC FLUID OPTERION HEALTH AG (CH) 2021-05-26 — — EP claimed
EP-3347486-A2 REDUCTION OF ER-MAM-LOCALIZED APP-C99 AND METHODS OF TREATING ALZHEIMER'S DISEASE The Trustees of Columbia University in the City of New York (US) 2018-07-18 — — EP claimed
WO-2017044807-A2 REDUCTION OF ER-MAM-LOCALIZED APP-C99 AND METHODS OF TREATING ALZHEIMER'S DISEASE THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2017-03-16 — — WO claimed
US-20070293563-A1 Novel Agents for Preventing and Treating Disorders Connected to Impaired Neurotransmission DSM IP ASSETS B.V. (NL) 2007-12-20 — — US claimed
EP-1802298-A2 NOVEL AGENTS FOR PREVENTING AND TREATING DISORDERS CONNECTED TO IMPAIRED NEUROTRANSMISSION DSMIP Assets B.V. (NL) 2007-07-04 — — EP claimed
WO-2006042441-A2 NOVEL AGENTS FOR PREVENTING AND TREATING DISORDERS CONNECTED TO IMPAIRED NEUROTRANSMISSION DSM IP ASSETS B.V. (NL) 2006-04-27 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070293563-A1 Novel Agents for Preventing and Treating Disorders Connected to Impaired Neurotransmission CHRNA2, CHRM1, CHRM5 ALOX15 1107/4885NDUFS8 649/4885COXFA4 635/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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