Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.55 |
| ▸ | NPR3 | P17342 | 4/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.52 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL914191 | 0.80 | SYK (0.61) | MAP3K5CSNK1A1EGFR | |
| SCHEMBL914009 | 0.80 | SYK (0.61) | MAP3K5CSNK1A1EGFR | |
| SCHEMBL914008 | 0.80 | SYK (0.61) | MAP3K5CSNK1A1EGFR | |
| SCHEMBL27736457 | 0.80 | HSD17B10 (0.55) | MAPKAPK2 | |
| SCHEMBL3243500 | 0.77 | MAP3K5 (0.60) | MAP3K5SCN9AKCNH2SCN5AABCG2 | |
| SCHEMBL915147 | 0.75 | JAK3 (0.59) | MAPKAPK2JAK2AURKAAURKB | |
| SCHEMBL915148 | 0.75 | JAK3 (0.59) | MAPKAPK2JAK2AURKAAURKB | |
| SCHEMBL12443884 | 0.75 | MAP3K5 (0.63) | MAP3K5ABCG2JAK2AURKAAURKB | |
| SCHEMBL3250658 | 0.74 | SCN9A (0.60) | MAP3K5NPR3SCN9AKCNH2SCN5A | |
| SCHEMBL3249544 | 0.73 | SCN9A (0.75) | SCN9AKCNH2SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |