NR1D2

Nuclear receptor subfamily 1 group D member 2 · Q14995 · NR1D2 on Sugi Atlas →

223 patent compounds predicted against NR1D2, 192 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL16636291	1.00	2/20
SCHEMBL16636446	1.00	2/20
SCHEMBL29378837	1.00	2/20
Sr9009 (SCHEMBL29444243)	1.00	2/20
Sr9011 (SCHEMBL29444252)	1.00	2/20
SCHEMBL29906522	1.00	2/20
Hydrochloric Acid (SCHEMBL16636902)	0.98	2/20
SCHEMBL16638084	0.98	2/20
Hydrochloric Acid (SCHEMBL29497168)	0.98	2/20
Hydrochloric Acid (SCHEMBL17982830)	0.98	2/20
SCHEMBL16636389	0.96	2/20
Hydrochloric Acid (SCHEMBL16637574)	0.96	2/20
Hydrochloric Acid (SCHEMBL17982803)	0.94	2/20
SCHEMBL16636464	0.85	2/20
SCHEMBL16636684	0.84	2/20
SCHEMBL16636549	0.83	2/20
SCHEMBL16636174	0.83	2/20
SCHEMBL16636730	0.83	2/20
SCHEMBL16636802	0.83	2/20
SCHEMBL18021959	0.81	2/20

Clinical trials — most relevant to NR1D2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Can Vitamin D3 Supplementation Affect Treatment Outcomes in Patients With Depression	PHASE4	UNKNOWN
The Role of Vitamin D Supplementation on Well Being and Symptoms of Depression During the Winter Season in Health Service Staff	PHASE4	COMPLETED
The Effect of Calcium and Vitamin D Supplements on Metabolic and Hormonal Disturbances in Polycystic Ovary Syndrome Patients	PHASE3	COMPLETED
Effects of Pioglitazone on High-density Lipoprotein (HDL) Function in Persons With Diabetes	PHASE3	COMPLETED
Exogenous Melatonin in Intensive Care Unit Chronodisruption	PHASE3	UNKNOWN
Activity of Regorafenib in Combination With Chemotherapy in Patients With Advanced Biliary Tract Cancer	PHASE1/PHASE2	COMPLETED
Fibrates in Pediatric Cholestasis	PHASE2	COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Effect of Bezafibrate on Muscle Metabolism in Patients With Fatty Acid Oxidation Defects	PHASE2	COMPLETED
N-DOSE AD: A Dose Optimization Trial of Nicotinamide Riboside in Alzheimer's Disease	PHASE2	COMPLETED
Comparative Study Between Obeticholic Acid Versus Vitamin E in Patients with Non-alcoholic Steatohepatitis	PHASE2	ACTIVE_NOT_RECRUITING
Choline Effects - Pre-symptomatic AD	PHASE1	COMPLETED
Immunolocalization of 1,25,Dihydroxyvitamin D3 in Aggressive Periodontitis Patients	nan	COMPLETED
Metabolic Investigation, Physical Performance, Physical Training At Different Times of the Day in Obese Women	nan	ACTIVE_NOT_RECRUITING
Gene Expression, Metabolomic, Microbiome, and Calcium Metabolism in Response to Varied Vitamin D Dosages	nan	COMPLETED
The Impact of Selective Vitamin D Receptor Activation on Clinical Outcomes in Septic Patients	nan	NOT_YET_RECRUITING
Replacement of Vitamin D in Patients With Active Tuberculosis	nan	COMPLETED
The Role of Programmed Death Ligand -1 (Pdl-1) in Lung Cancer	nan	COMPLETED
Prognostic Value of Vitamin D Levels in Egyptian Females With Breast Cancer	nan	UNKNOWN
Assessing the Effects of Alfacalcidol Intake on Expression of Involed Gene in Metabolism in Obese Subjects	nan	UNKNOWN
Role of Obeticholic Acid in the Patients of NAFLD With Raised ALT	nan	COMPLETED
RORC Genetic Polymorphism of Rheumatoid Arthritis	nan	COMPLETED
Vitamin D Levels in Liver Transplantation Recipients Prospective Observational Study	nan	COMPLETED
The Impact of Pharmacological and Electric Modulation of NMDA Pathway on the Cognitive Flexibility and Volitional Movement Preparation in Patients With Parkinson's Disease	nan	COMPLETED
The Effects of TZD on Fat Metabolism and Insulin Sensitivity in GH-Replaced GHD Patients	nan	COMPLETED
Assessment Vitamin D Analogues Intake Pathways on the Proteins Which Involved in Metabolic Rate in Obese Subjects	nan	UNKNOWN
Clinical Study on Circadian Genes Dysregulation in Patients With Glucocorticoid Disorders	nan	UNKNOWN
Effect of Surgical or Conservative Approach in Patients With Adrenal Incidentalomas	nan	UNKNOWN
Steroid Treatment of Idiopathic Nephrotic Syndrome	nan	COMPLETED
Drug Metabolizing Enzyme and Transporter Function in Chronic Kidney Disease	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a NR1D2 binder may also engage these)

Protein	Name	Similarity
Q60674	—	1.000	Q60674 →
Q63504	—	0.999	Q63504 →
P06212	—	0.993	P06212 →
Q9TU15	—	0.993	Q9TU15 →
P06211	—	0.992	P06211 →
Q9XSB5	—	0.992	Q9XSB5 →
Q3UV55	—	0.992	Q3UV55 →
A0JNE3	—	0.992	A0JNE3 →
Q6GN21	—	0.991	Q6GN21 →
Q08E02	—	0.991	Q08E02 →
P19785	—	0.991	P19785 →
Q91250	—	0.991	Q91250 →
Q9XSW2	—	0.990	Q9XSW2 →
Q63503	—	0.990	Q63503 →
P49882	—	0.990	P49882 →
P51448	—	0.990	P51448 →
Q9PVE2	—	0.990	Q9PVE2 →
Q8VIJ4	—	0.990	Q8VIJ4 →
P81559	—	0.989	P81559 →
Q64249	—	0.989	Q64249 →
P49884	—	0.989	P49884 →
Q9TV98	—	0.989	Q9TV98 →
Q29040	—	0.989	Q29040 →
B3SV56	—	0.988	B3SV56 →
O08537	—	0.988	O08537 →
Q62986	—	0.988	Q62986 →
ESR2	Estrogen receptor beta	0.988	landscape →
F1QLY4	—	0.988	F1QLY4 →
P50241	—	0.988	P50241 →
P51129	—	0.988	P51129 →