NRP1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL11899004	0.83	20/20
SCHEMBL11899199	0.83	20/20
SCHEMBL4569826	0.80	20/20
SCHEMBL4572275	0.80	20/20
SCHEMBL10475766	0.79	20/20
SCHEMBL11919578	0.78	20/20
SCHEMBL11934645	0.78	20/20
SCHEMBL10475858	0.78	20/20
SCHEMBL11916768	0.78	20/20
SCHEMBL10475803	0.77	20/20
SCHEMBL11916770	0.77	20/20
SCHEMBL11916775	0.75	20/20
SCHEMBL4572309	0.75	20/20
SCHEMBL10475774	0.74	20/20
SCHEMBL11901157	0.74	20/20
SCHEMBL11916772	0.74	20/20
SCHEMBL10475852	0.74	20/20
SCHEMBL11899172	0.74	20/20
SCHEMBL3711157	0.74	20/20
SCHEMBL4569810	0.74	20/20

Clinical trials — most relevant to NRP1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Clinical Study Evaluating the Anticancer Effect of Pentoxiphylline in Patients With Metastatic Colorectal Cancer	PHASE4	UNKNOWN
Enhancing Effect on Tumour Apoptosis With the Use of Pentoxifylline in Patients With Hodgkin Lymphoma	PHASE4	UNKNOWN
Effect of Metformin in Children With Type 1 Diabetes	PHASE2/PHASE3	COMPLETED
Ziv-Aflibercept Followed by Ziv-Aflibercept, Fluorouracil, and Leucovorin Calcium in Treating Patients With Stage IV Colorectal Cancer	PHASE2	WITHDRAWN
Safety and Efficacy of the PAINLESS Nerve Growth Factor CHF6467 in Optic Pathway Glioma (OPG)	PHASE2	ACTIVE_NOT_RECRUITING
A BIOmarker Driven Trial With Nivolumab and Ipilimumab or VEGFR tKi in Naïve Metastatic Kidney Cancer	PHASE2	COMPLETED
Cilostazol in Parkinson's Disease	PHASE2	NOT_YET_RECRUITING
Comparative Study to Test Safety and Efficacy of Neurotrophic and Cholinergic Treatment of Alzheimer's Disease	PHASE2	COMPLETED
Evaluation of Nicotinamide Riboside in Prevention of Small Fiber Axon Degeneration and Promotion of Nerve Regeneration	PHASE2	COMPLETED
Bevacizumab in Adults With Recurrent Respiratory Papillomatosis (RRP)	PHASE2	ACTIVE_NOT_RECRUITING
Study to Assess Safety and Efficacy of Fingolimod in Children With Rett Syndrome	PHASE1/PHASE2	COMPLETED
A Clinical Trial of AAV2-BDNF Gene Therapy in Early Alzheimer's Disease and Mild Cognitive Impairment	PHASE1	RECRUITING
Safety and Efficacy of the Fully Humanized Anti - VEGF Monoclonal Antibody LYN00101	PHASE1	WITHDRAWN
Comparison of Salivary Biormarkers Levels With Periodontal Clinical Parameters in Smokers and Non-Smokers With Different Periodontal Diseases	nan	COMPLETED
Role of Antibodies in Cognitive Dysfunction in Patients With Systemic Lupus Erythematosus	nan	COMPLETED
Serum Talin-1 and Cripto-1 in Colorectal Cancer	nan	NOT_YET_RECRUITING
Neurotrophin Expression in Infants as a Predictor of Respiratory and Neurodevelopmental Outcomes	nan	COMPLETED
NTRK 1,2,3 Rearrangements in Patients With Solid Tumors	nan	ACTIVE_NOT_RECRUITING
Genetic Biomarkers for the Response to Anti-VEGF (Vascular Endothelial Growth Factor).Treatment in Wet Age-related Macular Degeneration (Wet ARMD)	nan	COMPLETED
Studies of Neuregulin/ERBB Signaling in Human Heart	nan	RECRUITING
Biomarkers in Blood and Tissue Samples From Patients With Newly Diagnosed Neuroblastoma	nan	COMPLETED
Regular Exercise Improves Physical Capacity and Promotes Neurotrophins in Patients With Multiple Sclerosis	nan	COMPLETED
Prenatal Intervention of Maternal Stress - Breastfeeding & Infant Neurodevelopment	nan	COMPLETED
Changes in Skin Innervation of Neurologically Asymptomatic Type 2 Diabetic Patients: the Correlation With the Diabetic Parameters and Neurotrophins.	nan	UNKNOWN
Effectiveness of a Walking Program Modulating Cardioreparative Factors in Heart Failure	nan	COMPLETED
LRP1 Methylation and Colon Cancer	nan	COMPLETED
Leukemia Inhibitory Factor Level in Intrauterine Growth Restriction Neonates	nan	UNKNOWN
Clinical Significance of DKK2 Protein in Cerebral Ischemia-reperfusion Injury	nan	UNKNOWN
IGF and Other Neurotrophic Factors in Patients With Dementia	nan	COMPLETED
Blood-based Biomarkers for the Prognosis of Sports Related Concussion	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a NRP1 binder may also engage these)

Protein	Name	Similarity
Q9QWJ9	—	1.000	Q9QWJ9 →
P97333	—	1.000	P97333 →
P28824	—	1.000	P28824 →
Q8QFX6	—	1.000	Q8QFX6 →
P79795	—	1.000	P79795 →
Q9CPW0	—	0.988	Q9CPW0 →
Q0V8T0	—	0.987	Q0V8T0 →
Q0V8T3	—	0.987	Q0V8T3 →
Q0V8T5	—	0.986	Q0V8T5 →
Q8WYK1	—	0.986	Q8WYK1 →
Q5RD64	—	0.986	Q5RD64 →
Q0V8T8	—	0.984	Q0V8T8 →
Q0V8S9	—	0.984	Q0V8S9 →
Q0V8T9	—	0.983	Q0V8T9 →
Q9GMT4	—	0.983	Q9GMT4 →
Q9C0A0	—	0.983	Q9C0A0 →
Q0V8T4	—	0.983	Q0V8T4 →
Q8CFG8	—	0.983	Q8CFG8 →
Q0V8T7	—	0.983	Q0V8T7 →
Q7Z304	—	0.982	Q7Z304 →
Q5R544	—	0.982	Q5R544 →
Q4R577	—	0.982	Q4R577 →
Q9UHC6	—	0.981	Q9UHC6 →
Q5R1W3	—	0.981	Q5R1W3 →
Q63HQ2	—	0.980	Q63HQ2 →
Q0V8T6	—	0.980	Q0V8T6 →
A3KN33	—	0.980	A3KN33 →
Q8CG16	—	0.980	Q8CG16 →
P28825	—	0.980	P28825 →
P98065	—	0.979	P98065 →