PDHA1

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial · P08559 · PDHA1 on Sugi Atlas →

0 patent compounds predicted against PDHA1, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to PDHA1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Prevention of Renal Complications of Diabetes With Thiamine PHASE4UNKNOWN
Motor Function Efficacy of Pharmacological Treatments Targeting Energy Metabolism, in Parkinson's Patients PHASE4UNKNOWN
Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency: PHASE3ACTIVE_NOT_RECRUITING
Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis PHASE3COMPLETED
Efficacy and Safety of the Treatment of Pyruvate Dehydrogenase Deficiency Patients With Glycerol Phenylbutyrate (RAVICTI) PHASE2RECRUITING
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
Thiamine as an Adjunctive Therapy in Cardiac Surgery PHASE2COMPLETED
Thiamine as Adjunctive Therapy for Diabetic Ketoacidosis PHASE2COMPLETED
Use of Phenylbutyrate Therapy for Patients With Pyruvate Dehydrogenase Complex Deficiency. PHASE2COMPLETED
Hyperpolarized 13C Pyruvate MRI Scan in Predicting Tumor Aggressiveness in Patients With Renal Tumors PHASE2ACTIVE_NOT_RECRUITING
A Phase I, Open-Labeled, Single-Arm, Dose Escalation, Clinical and Pharmacology Study of Dichloroacetate (DCA) in Patients With Recurrent and/or Metastatic Solid Tumours PHASE1COMPLETED
Imaging of Traumatic Brain Injury Metabolism Using Hyperpolarized Carbon-13 Pyruvate EARLY_PHASE1ENROLLING_BY_INVITATION
Natural History and Advanced Genetic Study of Pyruvate Dehydrogenase Complex Deficiencies nanRECRUITING
Natural History Study of Pyruvate Dehydrogenase Deficiency nanUNKNOWN
UTSW HP [13-C] Pyruvate Injection in HCM nanCOMPLETED
Acute Effect of Fructose on Lipid Metabolism and Gender Differences nanCOMPLETED
Biologic Mechanisms for Pain Variation After Physical Activity in Osteoarthritis nanCOMPLETED
Carnitine Supplementation in Type 2 Diabetic Patients nanCOMPLETED
Effectiveness and Impact on the Quality of Life of Ketogenic Diet in Pediatric Patients nanRECRUITING
Thiamine As An Adjuvant Therapy For Hyperlactatemia In Septic Shock Patients nanUNKNOWN
Combined Effect of Exercise Intensity With Nutritional Supplementation on Skeletal Muscle Function nanCOMPLETED
Microbiome Composition and Biomarker Discovery in Refractory Pediatric Epilepsy nanWITHDRAWN
Effect of Fatty Liver on TCA Cycle Flux and the Pentose Phosphate Pathway nanCOMPLETED
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population nanUNKNOWN
McArdle Disease Treatment by Ketogenic Diet nanCOMPLETED
Metabolic Remodeling in Pulmonary Arterial Hypertension (PAH) nanCOMPLETED
Pyruvate Kinase Deficiency Natural History Study nanCOMPLETED
Screening of IDH1 and IDH2 Gene Mutations in Adult Acute Myeloid Leukemia for Possible Targeted Therapy nanUNKNOWN
Energy Expenditure and Quality of Life in Epilepsy nanWITHDRAWN
Molecular Mechanisms of Exercise Benefits to Insulin Resistant People nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a PDHA1 binder may also engage these)

ProteinNameSimilarity
Q8HXW9 1.000 Q8HXW9 →
A5A6L0 1.000 A5A6L0 →
P29804 1.000 P29804 →
A7MB35 1.000 A7MB35 →
Q5R490 1.000 Q5R490 →
P35486 1.000 P35486 →
P26284 0.999 P26284 →
P52900 0.993 P52900 →
P52903 0.989 P52903 →
PDHA2 Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial 0.987 landscape →
P52901 0.985 P52901 →
G0SHF3 0.984 G0SHF3 →
P16387 0.984 P16387 →
P35487 0.982 P35487 →
P52899 0.982 P52899 →
Q6Z5N4 0.982 Q6Z5N4 →
Q8H1Y0 0.981 Q8H1Y0 →
Q06437 0.981 Q06437 →
P26268 0.981 P26268 →
P26267 0.980 P26267 →
O13366 0.976 O13366 →
Q654V6 0.974 Q654V6 →
Q10489 0.972 Q10489 →
P52902 0.969 P52902 →
Q54C70 0.964 Q54C70 →
O24457 0.956 O24457 →
P14874 0.952 P14874 →
A0A2I2F2I5 0.951 A0A2I2F2I5 →
Q41768 0.950 Q41768 →
Q9V9A7 0.949 Q9V9A7 →