PDHA2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to PDHA2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Motor Function Efficacy of Pharmacological Treatments Targeting Energy Metabolism, in Parkinson's Patients	PHASE4	UNKNOWN
Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency:	PHASE3	ACTIVE_NOT_RECRUITING
Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis	PHASE3	COMPLETED
Efficacy and Safety of the Treatment of Pyruvate Dehydrogenase Deficiency Patients With Glycerol Phenylbutyrate (RAVICTI)	PHASE2	RECRUITING
Acetylcarnitine and Insulin Sensitivity	PHASE2	COMPLETED
Thiamine as an Adjunctive Therapy in Cardiac Surgery	PHASE2	COMPLETED
Thiamine as Adjunctive Therapy for Diabetic Ketoacidosis	PHASE2	COMPLETED
Use of Phenylbutyrate Therapy for Patients With Pyruvate Dehydrogenase Complex Deficiency.	PHASE2	COMPLETED
Hyperpolarized 13C Pyruvate MRI Scan in Predicting Tumor Aggressiveness in Patients With Renal Tumors	PHASE2	ACTIVE_NOT_RECRUITING
A Phase I, Open-Labeled, Single-Arm, Dose Escalation, Clinical and Pharmacology Study of Dichloroacetate (DCA) in Patients With Recurrent and/or Metastatic Solid Tumours	PHASE1	COMPLETED
Imaging of Traumatic Brain Injury Metabolism Using Hyperpolarized Carbon-13 Pyruvate	EARLY_PHASE1	ENROLLING_BY_INVITATION
Natural History Study of Pyruvate Dehydrogenase Deficiency	nan	UNKNOWN
Natural History and Advanced Genetic Study of Pyruvate Dehydrogenase Complex Deficiencies	nan	RECRUITING
UTSW HP [13-C] Pyruvate Injection in HCM	nan	COMPLETED
Biologic Mechanisms for Pain Variation After Physical Activity in Osteoarthritis	nan	COMPLETED
Acute Effect of Fructose on Lipid Metabolism and Gender Differences	nan	COMPLETED
Combined Effect of Exercise Intensity With Nutritional Supplementation on Skeletal Muscle Function	nan	COMPLETED
Carnitine Supplementation in Type 2 Diabetic Patients	nan	COMPLETED
Microbiome Composition and Biomarker Discovery in Refractory Pediatric Epilepsy	nan	WITHDRAWN
Thiamine As An Adjuvant Therapy For Hyperlactatemia In Septic Shock Patients	nan	UNKNOWN
Effect of Fatty Liver on TCA Cycle Flux and the Pentose Phosphate Pathway	nan	COMPLETED
McArdle Disease Treatment by Ketogenic Diet	nan	COMPLETED
Pyruvate Kinase Deficiency Natural History Study	nan	COMPLETED
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic Acidemia	nan	COMPLETED
Metabolic Remodeling in Pulmonary Arterial Hypertension (PAH)	nan	COMPLETED
Molecular Mechanisms of Exercise Benefits to Insulin Resistant People	nan	COMPLETED
Role of LDH as a Predictor of Treatment Outcomes in Hepatocellular Carcinoma	nan	UNKNOWN
ALDH2 Single Nucleotide Polymorphisms and Prognosis of Esophageal Cancer Patients	nan	RECRUITING
Effectiveness and Impact on the Quality of Life of Ketogenic Diet in Pediatric Patients	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a PDHA2 binder may also engage these)

Protein	Name	Similarity
P35487	—	0.995	P35487 →
P26267	—	0.993	P26267 →
Q8HXW9	—	0.993	Q8HXW9 →
Q06437	—	0.993	Q06437 →
P16387	—	0.990	P16387 →
P52903	—	0.990	P52903 →
O13366	—	0.988	O13366 →
P52899	—	0.988	P52899 →
A7MB35	—	0.988	A7MB35 →
P26268	—	0.988	P26268 →
Q8H1Y0	—	0.988	Q8H1Y0 →
P29804	—	0.988	P29804 →
A5A6L0	—	0.987	A5A6L0 →
P52901	—	0.986	P52901 →
Q5R490	—	0.986	Q5R490 →
Q54C70	—	0.986	Q54C70 →
P35486	—	0.986	P35486 →
Q10489	—	0.984	Q10489 →
P26284	—	0.983	P26284 →
P52900	—	0.982	P52900 →
PDHA1	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	0.982	landscape →
Q6Z5N4	—	0.982	Q6Z5N4 →
Q654V6	—	0.980	Q654V6 →
P52902	—	0.978	P52902 →
O24457	—	0.974	O24457 →
G0SHF3	—	0.971	G0SHF3 →
Q9R9N5	—	0.967	Q9R9N5 →
P21839	—	0.963	P21839 →
P35738	—	0.963	P35738 →
Q7XTJ3	—	0.963	Q7XTJ3 →