PFKP

ATP-dependent 6-phosphofructokinase, platelet type · Q01813 · PFKP on Sugi Atlas →

392 patent compounds predicted against PFKP, 377 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Vistusertib (SCHEMBL290672)	1.00	1/20
Vistusertib (SCHEMBL1214881)	1.00	1/20
Vistusertib (SCHEMBL20734874)	1.00	1/20
Vistusertib (SCHEMBL22449928)	1.00	1/20
Vistusertib (SCHEMBL29350053)	1.00	1/20
Vistusertib (SCHEMBL29353400)	1.00	1/20
Vistusertib (SCHEMBL29397309)	1.00	1/20
SCHEMBL22449835	0.90	1/20
SCHEMBL10225658	0.89	1/20
SCHEMBL22030452	0.89	1/20
SCHEMBL22858573	0.89	1/20
SCHEMBL22259415	0.85	1/20
SCHEMBL16024023	0.85	1/20
Mti-31 (SCHEMBL17354025)	0.84	1/20
Mti-31 (SCHEMBL29638190)	0.84	1/20
Mti-31 (SCHEMBL29921552)	0.84	1/20
SCHEMBL22449763	0.83	1/20
SCHEMBL22449816	0.83	1/20
SCHEMBL22449927	0.83	1/20
SCHEMBL22594118	0.83	1/20

Clinical trials — most relevant to PFKP by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Effects of Tirofiban in Diabetic Patients Undergoing Elective Percutaneous Coronary Intervention	PHASE4	UNKNOWN
Reversal of the Anti-platelet Effects of Ticagrelor	PHASE4	COMPLETED
Prasugrel Versus Clopidogrel to TREAT High Platelet Reactivity	PHASE4	COMPLETED
Effects of Aspirin Treatment on Fibrin Network Formation in Patients With Type 1 Diabetes	PHASE4	COMPLETED
Genotyping Guided Individualized Treatment of Clopidogrel and Ticagrelor in ACS	PHASE2/PHASE3	UNKNOWN
Migraine Headaches Elimination With Patent Foramen Ovale-Directed Therapy	PHASE3	NOT_YET_RECRUITING
Bioenergetic Effect of Pioglitazone in CLD-PH	PHASE2	RECRUITING
Bempedoic Acid Therapy for Polycystic Kidney Disease	PHASE2	NOT_YET_RECRUITING
Acetylcarnitine and Insulin Sensitivity	PHASE2	COMPLETED
To Assess Safety of Mitapivat and Provide Proof of Concept of the Efficacy of the Drug in Patients With RBC Membranopathies or CDAII.	PHASE2	RECRUITING
Escalating Clopidogrel by Involving a Genetic Strategy - Thrombolysis In Myocardial Infarction 56	PHASE2	COMPLETED
Uterine Artery Doppler Changes After Vaginal Administration of Isosorbide Mononitrate In Patients With URPL	EARLY_PHASE1	UNKNOWN
Zhongshan Ketogenic Diet Study 1	nan	RECRUITING
Genotype -Phenotype Correlation of PKLR Variants With Pyruvate Kinase, 2,3-Diphosphglycerate and Adenosine Triphosphate Activities in Red Blood Cells of People With Sickle Cell Disease	nan	RECRUITING
Effect of Acute Fructose Load in Human	nan	COMPLETED
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
The Role of Sugars in Fat Accumulation in the Liver	nan	RECRUITING
Effect of COVID-19 on Platelet Mitochondrial Bioenergetic, Antioxidants and Oxidative Stress in Infertile Men.	nan	UNKNOWN
Dried Fruit and Postprandial Glycemia Trial	nan	UNKNOWN
The Effect of Morning vs Evening Aerobic Exercise Training on Cardiac Remodeling and Function Improvement in Patients After ST Elevation Myocardial Infarction	nan	RECRUITING
Hypercoagulability Study Using Haemostatic Techniques in Patients With Inflammatory Bowel Disease	nan	UNKNOWN
Pyruvate Kinase Deficiency Epidemiological Study (PIECE)	nan	COMPLETED
Inflammatory Markers and Cbc Indices in Severely Malnourished Children	nan	UNKNOWN
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH)	nan	COMPLETED
Study of Polymorphisms in pear1 Gene Link to Platelet Activation and Signaling Pathway Variations	nan	WITHDRAWN
METabolic PROFILE of Hepatocarcinoma and Pancreatic Tumors	nan	RECRUITING
Normal Donor Blood Draws for Platelet Studies and Biomarker Evaluation (ND-PLT)	nan	RECRUITING
Interval Training in Cardiac Rehabilitation	nan	COMPLETED
Identification of Clopidogrel CYP2C19 Metabolizer and Thienopyridine Treatment After an Acute Coronary Syndrome	nan	COMPLETED
Hemodynamic Changes in Acute Ischaemic Stroke Patients	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a PFKP binder may also engage these)

Protein	Name	Similarity
Q5R636	—	1.000	Q5R636 →
P47859	—	1.000	P47859 →
Q867C9	—	1.000	Q867C9 →
P00511	—	1.000	P00511 →
Q60HD9	—	1.000	Q60HD9 →
Q5RAG9	—	1.000	Q5RAG9 →
P12382	—	1.000	P12382 →
Q0IIG5	—	1.000	Q0IIG5 →
P52784	—	1.000	P52784 →
Q5R7V5	—	1.000	Q5R7V5 →
P47857	—	1.000	P47857 →
P47860	—	1.000	P47860 →
A1A4J1	—	1.000	A1A4J1 →
P08237	—	1.000	P08237 →
Q9WUA3	—	1.000	Q9WUA3 →
P47858	—	1.000	P47858 →
Q2HYU2	—	1.000	Q2HYU2 →
P30835	—	1.000	P30835 →
PFKL	ATP-dependent 6-phosphofructokinase, liver type	0.999	landscape →
P52034	—	0.995	P52034 →
P78985	—	0.993	P78985 →
Q27778	—	0.992	Q27778 →
Q9HGZ1	—	0.992	Q9HGZ1 →
Q2RNU4	—	0.990	Q2RNU4 →
Q4W9B8	—	0.990	Q4W9B8 →
Q9TZL8	—	0.987	Q9TZL8 →
Q9FAF8	—	0.985	Q9FAF8 →
PC	Pyruvate carboxylase, mitochondrial	0.984	landscape →
Q27665	—	0.983	Q27665 →
Q8VYN6	—	0.983	Q8VYN6 →