PHKA1

Phosphorylase b kinase regulatory subunit alp · P46020 · PHKA1 on Sugi Atlas →

282 patent compounds predicted against PHKA1, 250 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Hydrochloric Acid (SCHEMBL8321621)	1.00	3/20
SCHEMBL8323028	1.00	3/20
Hydrochloric Acid (SCHEMBL8323337)	1.00	3/20
Hydrochloric Acid (SCHEMBL8323340)	1.00	3/20
Hydrochloric Acid (SCHEMBL8323341)	1.00	3/20
SCHEMBL8325893	1.00	3/20
SCHEMBL8325899	1.00	3/20
SCHEMBL8325901	1.00	3/20
SCHEMBL30569343	1.00	3/20
SCHEMBL8325755	0.84	3/20
SCHEMBL8325756	0.84	3/20
SCHEMBL8325761	0.84	3/20
SCHEMBL8328590	0.84	3/20
Hydrochloric Acid (SCHEMBL8325486)	0.83	3/20
Hydrochloric Acid (SCHEMBL8325487)	0.83	3/20
Hydrochloric Acid (SCHEMBL8325673)	0.83	3/20
Hydrochloric Acid (SCHEMBL8325674)	0.83	3/20
Hydrochloric Acid (SCHEMBL8322489)	0.81	3/20
Hydrochloric Acid (SCHEMBL8326455)	0.81	3/20
Hydrochloric Acid (SCHEMBL8326458)	0.81	3/20

Clinical trials — most relevant to PHKA1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Study in Adult Ph-positive ALL	PHASE2	UNKNOWN
PhII 5-Azacytidine Plus Valproic Acid and Eventually Atra in Intermediate II and High Risk MDS	PHASE2	COMPLETED
PKC412 and 5-Azacytidine	PHASE1/PHASE2	COMPLETED
Doxycycline in Human Pulmonary Tuberculosis	PHASE2	COMPLETED
Everolimus in Treating Patients With Relapsed or Refractory Multiple Myeloma	PHASE2	COMPLETED
Clinical Study of EBV-LMP1 Targeted DNAzyme to Treat Nasopharyngeal Carcinoma	PHASE1/PHASE2	COMPLETED
Biological Effects of Quercetin in COPD Phase II	PHASE2	UNKNOWN
Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Patients With a PI3K Alteration and HR+/Her2- Breast Cancer	PHASE1/PHASE2	RECRUITING
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Effect Of Scaling and Root Planning on ALP in Saliva and GCF In Periodontitis Patients Compared With Healthy Individuals	nan	UNKNOWN
Unraveling Genetics of HypoPhosPhatasia (HPP Genetics)	nan	COMPLETED
The Effect of Monoallelic Variants in the ALPL Gene on the Natural Course of Hypophosphatasia in Russia	nan	RECRUITING
Characteristics of Hypophosphatasia in Adult Patients in Rheumatology	nan	UNKNOWN
United States Hypophosphatasia Molecular Research Center	nan	COMPLETED
p-AKT Expression on Clinical Outcomes in Malignant Lymphoma	nan	COMPLETED
Planetary Habitat Simulation: Bone Metabolism Studies	nan	COMPLETED
Prospective, Longitudinal, Observational Registry of Adult Patients With Hypophosphatasia (REG-HYPO)	nan	RECRUITING
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Characteristics of Hypophosphatasia in Adult Patients in Rheumatology and Their Value in Developing an Algorithm to HPP-diagnosis - the COHIR Multi-center Study	nan	RECRUITING
Tissue-nonspecific Alkaline Phosphatase in Phosphate and Pyrophosphate Homeostasis.	nan	COMPLETED
Study of Autoimmune Lymphoproliferative Syndrome (ALPS)	nan	RECRUITING
Pathophysiology of Paget's Disease of Bone	nan	COMPLETED
Studying Phosphorus Metabolism	nan	COMPLETED
Pulmonary Hypertension, Hypoxia and Sickle Cell Disease	nan	COMPLETED
Role of the Liver in Glucose Homeostasis Using Metabolic Imaging	nan	COMPLETED
Calciotropic Effects After HCG Stimulation Test	nan	COMPLETED
Immune Responses in Hepatocellular Carcinoma Patients After Treatment With Direct Acting Antiviral Drugs	nan	COMPLETED
The Role Of FGF23, Klotho, And Sclerostin In Kidney Stone Formers	nan	UNKNOWN
Genetic Mapping of Atherogenic Lipoprotein Phenotypes	nan	COMPLETED
The Role of Vitamin K2 in Preventing Glucocorticoid-Induced Bone Loss in Children With Nephrotic Syndrome	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a PHKA1 binder may also engage these)

Protein	Name	Similarity
Q64649	—	1.000	Q64649 →
Q8BWJ3	—	1.000	Q8BWJ3 →
PHKB	Phosphorylase kinase beta subunit	1.000	landscape →
P18688	—	1.000	P18688 →
P46018	—	0.999	P46018 →
PHKA2	Phosphorylase b kinase regulatory subunit alpha, liver isoform	0.999	landscape →
Q7TSH2	—	0.998	Q7TSH2 →
P18826	—	0.998	P18826 →
Q9W6R1	—	0.997	Q9W6R1 →
P03541	—	0.996	P03541 →
Q9VLS1	—	0.996	Q9VLS1 →
O84702	—	0.996	O84702 →
Q9KB03	—	0.995	Q9KB03 →
P22047	—	0.994	P22047 →
Q77GW1	—	0.994	Q77GW1 →
P19239	—	0.994	P19239 →
P0DJV7	—	0.994	P0DJV7 →
A9MP50	—	0.994	A9MP50 →
Q8AZM0	—	0.994	Q8AZM0 →
P35671	—	0.994	P35671 →
P34335	—	0.994	P34335 →
Q20PL8	—	0.994	Q20PL8 →
Q8BD31	—	0.994	Q8BD31 →
Q93CE8	—	0.994	Q93CE8 →
P07400	—	0.994	P07400 →
P0CA08	—	0.994	P0CA08 →
P84786	—	0.994	P84786 →
P12798	—	0.993	P12798 →
P18272	—	0.993	P18272 →
Q18892	—	0.993	Q18892 →